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Benjamin Caplan, MD, stands at the forefront of medical cannabis care as the Founder and Chief Medical Officer of CED Clinic and CED Foundation. His entrepreneurial journey further extends as the Founder of multiple medical cannabis technology and educational platforms and as a medical advisor to the prestigious cannabis investment fund, GreenAXS Capital. Within digital healthcare, Dr. Caplan co-founded EO Care, Inc, a pioneering digital therapeutic and telemedicine platform, offering personalized cannabis care and product plans and continuous clinical guidance to a global clientele seeking a reliable, evidence-based cannabis care partner. Adding to his repertoire of contributions to the medical cannabis arena, Dr. Caplan has recently published “The Doctor-Approved Cannabis Handbook,” an industry-first resource empowering readers with the full scope of the therapeutic potential of cannabis. Through his multifaceted involvement, Dr. Caplan continuously strives to bridge the gap between traditional medicine and cannabis care, making a significant impact in evolving holistic healthcare.

Erin Caplan, NP is a board-certified Pediatric Nurse Practitioner with a master’s-level medical education from Simmons. Her extensive clinical journey has been enriched through roles at Massachusetts General Hospital, Hyde Park Pediatrics, Atrius Healthcare, and Dana-Farber Cancer Institute, where she has provided both inpatient and outpatient primary care to some of the most fragile and challenging pediatric patients. A registered cannabis care provider licensed by the Massachusetts Cannabis Control Commission, Erin seamlessly blends her pediatric expertise with the nuance and adaptability required for personalized cannabis care. A community leader, avid athlete, and dedicated mother of four, Erin’s compassionate bedside manner and steadfast commitment to evidence-based practice have earned her the trust and appreciation of patients and families, showcasing her as a harmonious blend of clinical excellence with a personal touch.

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Cannabis in Pregnancy: 5 Crucial Insights

February 13, 2025Cannabis in Pregnancy: 5 Crucial Insights Essential Science and Real-World Guidance for Expectant Mothers In today’s fast-paced world—where stress, politics, and the endless digital hustle often leave us questioning every decision—the issue of cannabis in pregnancy has emerged as a topic of genuine importance. If you’re curious whether cannabis is a miracle remedy, a misunderstood substance, or somewhere in between, you’re in the right place. In this blog, we break down 5 crucial insights that balance emerging scientific debates with practical, real-world guidance. (And if you’re hungry for every last detail, my full gold-standard document is available here.) A version of this review also lives on my Substack 1. A Rising Trend with Real Implications Cannabis use during pregnancy is rapidly gaining attention. With legalization spreading and “natural” solutions on everyone’s lips, self-reported use has increased from 3.4% in 2002 to 7.0% in 2017 (Corsi et al., 2019). While these numbers might be an underestimate, they signal a trend that we simply cannot ignore. Think This Through: How might your own experiences—or those of people around you—reflect this growing trend? 2. The Research Roadblock: What We Know and What We Don’t Unlike alcohol and tobacco, whose dangers are well documented over decades, our understanding of cannabis in pregnancy comes mostly from observational studies. Ethical constraints rule out randomized controlled trials, so we rely on data that, while useful, often comes with a healthy dose of uncertainty. Confounding factors like tobacco use and socioeconomic challenges further muddy the waters. Still, researchers have pinpointed some key areas: Fetal Development: Laboratory studies hint at potential interference with early brain formation, yet clinical data do not support a consistent pattern of birth defects. Placental Function: There’s some evidence that THC might affect nutrient flow, but overall outcomes remain inconclusive. Think This Through: When faced with multiple risk factors, what questions should you be asking your healthcare provider? 3. Balancing Theories and Reality The debate over cannabis in pregnancy is as multifaceted as modern life itself. On one side, mechanistic research warns that THC could disrupt the endocannabinoid system (ECS)—vital for brain and organ development. On the other, population studies have yet to reveal a definitive “cannabis syndrome” or clear-cut birth defects linked to its use. And here’s an intriguing twist: emerging theories even suggest that for mothers with an endocannabinoid deficiency, controlled supplementation might help normalize development—much like how vitamins correct a deficiency. Think This Through: How do you weigh these laboratory-based theoretical concerns against clinical data that show little evidence of widespread harm? 4. Practical Considerations for Real Life Deciding whether to use cannabis during pregnancy isn’t one-size-fits-all. Several factors are crucial: Timing is Everything: – In the first trimester, when the embryo is laying its foundational blueprint (neural tube formation and early organ development), even small disruptions might theoretically cause long-term issues. – In the later trimesters, while concerns persist about subtle impacts on brain growth and placental efficiency, clinical outcomes are generally less alarming. Dose and Frequency: Occasional, low-dose use is very different from daily, heavy use—and current research rarely distinguishes between these patterns. Method of Use: Whether you smoke, vape, consume edibles, or use tinctures can affect both the speed and extent of absorption. For example, edibles have a delayed but prolonged effect, while smoking delivers rapid, potent doses. Think This Through: How might your lifestyle, symptoms, and personal health goals influence your choice of cannabis use, and what clarifying questions will you ask your provider? 5. Making the Informed Choice Ultimately, the decision to use cannabis during pregnancy is deeply personal. Providers and patients must engage in honest, open conversations, weighing the potential relief for severe symptoms (like unrelenting nausea or chronic pain) against uncertain long-term risks. Although major medical bodies advise caution, real-life complexities sometimes demand a tailored approach. If you’re feeling uncertain, expert guidance is just a call away—CED Clinic’s telemedicine support connects you with specialists who offer evidence-based advice to help you navigate these decisions. Think This Through: Reflect on your unique health challenges. What are the most pressing issues you face, and how might a candid discussion with your provider guide you toward the best decision? Sneak Preview: Detailed Insights from the Full Version For those who crave deeper analysis, here’s an excerpt from our detailed section on “Timing Matters: Early vs. Late Pregnancy Effects.” This sample demonstrates the level of scientific detail—including comprehensive explanations, concrete references, and nuanced debate—you’ll find in the full version (which is over 50 pages and packed with more than 25 references). Excerpt from Full Version: First Trimester – The Foundation Stage: During the first trimester, the embryo undergoes rapid development, including neural tube formation and early organogenesis. Theoretically, exogenous cannabinoids like THC could disrupt these processes by interfering with the ECS, essential for neural connectivity. Laboratory studies have indicated that THC binding to CB1 receptors might alter neuronal migration and synaptic formation, raising concerns about potential long-term cognitive effects. However, epidemiological evidence does not consistently show a pattern of cannabis-related birth defects. Some researchers even suggest that in cases of maternal endocannabinoid deficiency, controlled cannabinoid supplementation might help normalize developmental signaling—much like correcting a vitamin deficiency (Costa, 2016; Schreiber & Pick, 2019). Second & Third Trimester – Growth and Maturation: In later stages, as the fetus grows and brain networks mature, ongoing THC exposure might affect neurotransmitter systems and placental efficiency. Yet, the clinical data indicate that while there are modest associations with outcomes like low birth weight, these are often confounded by other factors. The full version discusses these findings in greater detail, comparing various consumption methods, dosages, and even exploring potential benefits under certain conditions. Think This Through: Consider the interplay of laboratory studies, clinical observations, and emerging theories. How might this comprehensive analysis deepen your understanding of the complex choices involved in cannabis use during pregnancy? A Quick Recap To sum it up, our exploration of cannabis in pregnancy reveals a nuanced landscape where theoretical concerns meet real-world evidence. While laboratory data hint at potential risks, clinical outcomes do not uniformly support widespread harm—and in some cases, cannabinoids might even play a beneficial role. If you’re ready to dive deeper, the full version shares all the comprehensive details you need! [...] Read more...

5 Huge Flaws in Cannabis and Brain Function Research

February 6, 2025Are We Really Seeing Damage—Or Just Bad Science? 5 Huge Flaws in Cannabis and Brain Function Research If you’ve read the headlines lately, or for the 4.4 million people who sawHuberman’s tweet, you’d think cannabis users are one hit away from forgetting their own names. Studies claim cannabis impairs brain function, wrecks memory, and shrinks gray matter like a raisin in the sun. But hold up—how reliable is this research, really? This recent study published in JAMA, “Brain Function Outcomes of Recent and Lifetime Cannabis Use” claims that heavy cannabis use is linked to lower brain activation during working memory tasks. Sounds alarming. But before we all start panic-quit puffing, allow me to help you take a hard look at five serious flaws in how cannabis and brain function research is done—and why the truth is far more complicated than these headlines suggest. 1. Correlation Is Not Causation (But It Sure Sells Headlines) Most cannabis and brain function studies are cross-sectional, meaning they take a single snapshot in time. Imagine looking at a photo of someone drenched in water and declaring, “They must have jumped into a pool!” Maybe. But maybe it was rain. Maybe they spilled their drink. Maybe they just sweat a lot. Photo Credit Why This Is a Problem for Cannabis Research: Although the authors of the work, and the editors of the magazine that gets lots of press, would love for you to let them do the thinking for you, we don’t know if cannabis use caused brain changes or if people with certain brain differences were more likely to use cannabis in the first place. Did other factors (stress, genetics, environment, diet, sleep habits) play a bigger role? We don’t know—because this kind of study can’t tell us. Brain activation differences don’t automatically mean damage—sometimes they mean efficiency. Lower activation could just mean the brain is working smarter, not harder. 💡 Better Science: Longitudinal studies that track individuals before they start using cannabis and monitor changes over time. Until then, it’s all just educated guesswork. The Cannabis Conundrum: Science, Stigma, and the Battle Against Bias There’s a reason why cannabis research often reads like a scripted episode of Reefer Madness, and it has little to do with the plant itself. Unlike pharmaceuticals with billion-dollar research budgets and legions of lobbyists, cannabis is a natural medicine that, by its very nature, threatens entrenched industries—from Big Pharma to Big Alcohol to Big Tobacco. Let’s be clear: there’s no money in proving cannabis is safe. There’s no financial incentive for massive, multi-center trials to validate its therapeutic potential the way there is for, say, the next blockbuster psychiatric drug. The machine that funds research thrives on patentable, synthetic compounds—not a plant that anyone can grow. Why Does This Matter? Because in real, honest science, you don’t set out to prove a position—you set out to explore a hypothesis. Yet, the lopsided cultural bias against cannabis means that most studies don’t ask: ❌ “How can cannabis be safely incorporated into medicine?” ❌ “What populations might benefit the most?” ❌ “What are the full mechanisms—both harms and benefits—of cannabinoids in the brain?” Instead, the dominant research questions tend to sound more like: ✅ “How does cannabis impair brain function?” ✅ “How addictive is cannabis?” ✅ “What are the risks of long-term cannabis use?” Do you see the problem? If you only look for harm, you will find it. That’s confirmation bias at its finest. And it’s precisely why cannabis science demands extra skepticism. The Missing Education: Why Doctors Know Next to Nothing About Cannabis Ask the average physician how cannabis interacts with the endocannabinoid system—the regulatory network that influences pain, mood, immune function, and cognition—and you’ll likely get a blank stare. Why? Because cannabis is not taught in medical school. That’s right—while future doctors get hundreds of hours of training on opioids, antidepressants, and every manner of synthetic pharmaceutical, they receive next to nothing on the body’s own cannabinoid system—a system that literally every human being has. The irony? We teach doctors about the opioid receptors but not about the cannabis receptors, even though one class of drugs is fueling an overdose epidemic and the other has never killed anyone. This blind spot in education has consequences: Doctors default to outdated, prohibition-era myths about cannabis. Medical professionals rely on research that is often biased against cannabis from the start. A plant with thousands of years of therapeutic history is treated like a fringe drug instead of an area of legitimate study. This isn’t just a research gap—it’s a systemic failure in modern medicine. Who Controls the Narrative? Follow the Money Let’s not pretend that science operates in a vacuum. The way research is conducted, funded, and reported is deeply political and profit-driven. Consider this: 💰 Pharmaceutical companies fund the majority of medical research. Their goal? Return on investment, not necessarily objective truth. 💰 Cannabis poses a direct threat to billion-dollar industries, including painkillers, sleep aids, antidepressants, and alcohol. 💰 Corporate interests control media narratives. If a study suggests cannabis is harmful, it’s a headline. If a study suggests benefits? It’s buried in academic journals with no media coverage. So when you see a big, bold claim about cannabis harming the brain, ask yourself: Who funded this research? What’s the study’s real mission? Why isn’t the full picture—including benefits—being reported? Because in honest science, you don’t get clickbait headlines making sweeping declarations. You get nuance. You get careful, measured exploration. And you get a fair read of both sides of the evidence. If we don’t demand critical thinking in how we interpret cannabis research, we’re not just failing the plant—we’re failing science itself. 2. The Definition of “Heavy Use” Is Totally Arbitrary This study divides cannabis users into: ✅ Nonusers (<10 lifetime uses) ✅ Moderate users (10–999 uses) ✅ Heavy users (>1000 uses) Hold on—who decided that 1000+ uses is “heavy”? And does 999 uses magically mean your brain is fine, but 1001 uses turns it into mashed potatoes? What’s Wrong With This? It ignores potency—smoking low-THC cannabis daily for 20 years isn’t the same as dabbing 90% THC concentrate weekly. It ignores consumption method—smoking, vaping, and edibles all affect the brain differently. It lumps all users into broad categories without considering frequency, dose, or duration. 💡 What We Need Instead: Studies should analyze THC levels, consumption method, and long-term patterns, not just slap users into vague categories. 3. No One’s Talking About CBD—And That’s a Huge Mistake Cannabis isn’t just THC. CBD (cannabidiol) is its quieter, more responsible sibling—one that might actually protect the brain. What This Study Gets Wrong: It doesn’t separate high-THC users from those using CBD-rich cannabis. CBD has neuroprotective properties, meaning it might actually counteract some of THC’s negative cognitive effects. The real question isn’t just “Does cannabis affect brain function?” but “How do different cannabis compounds impact cognition?” 💡 A Smarter Approach: Future studies should compare THC-heavy vs. CBD-rich cannabis to get a clearer picture. Final Thoughts Look, cannabis isn’t a free pass to a sharper brain, but these studies don’t prove it’s frying your neurons either. What they do prove is that we need better research—studies that actually control for variables, track long-term use, and separate correlation from causation. 🔑 Bottom Line: ✅ One study isn’t proof—we need long-term research before making the types of bold claims made here. ✅ CBD vs. THC matters—they have vastly different effects. ✅ Brain activation changes ≠ permanent damage—context matters. ✅ Consider the full picture—lifestyle, stress, and withdrawal effects play a huge role. 👉 Want more actual science on cannabis? Join me on my newsletter and keep the wool from your eyes! [...] Read more...

Mold, Bacteria, and Yeast—Oh My! What’s Lurking in Your Weed?

February 5, 2025 A shocking issue, a broken system, and what it means for consumers Why Your Weed Might Come with a Side of Fungus (and What to Do About It) Imagine dropping fifty bucks on a perfectly packaged eighth—maybe a fresh, citrusy sativa or a mellow, earthy indica—only to find out later that your top-shelf flower came with an unwanted fungal upgrade. Massachusetts just saw its biggest-ever cannabis recall, pulling products from 29 dispensaries after finding yeast, mold, and bacteria contamination in hundreds of thousands of products sold over 8 months before anyone caught the issue. For most recreational users, this might just mean an annoying trip back to the dispensary for an exchange. But for medical cannabis patients—especially those with weakened immune systems—this is a real health risk. The recall raises a crucial question: If cannabis is lab-tested, why is contaminated product still making it into people’s hands? And more importantly, how do you protect yourself from moldy weed? Why Moldy Weed is More Than Just Gross Most people wouldn’t knowingly eat moldy bread or drink spoiled milk, but when it comes to cannabis, there’s a dangerous misconception that fire will “kill” mold and make it safe to smoke. That’s not how it works. 🔬 Here’s what you need to know about smoking contaminated cannabis: ✚ Mold spores survive combustion. Even at high temperatures, some fungal spores can still enter your lungs and cause serious infections. ✚ Bacteria in cannabis can cause foodborne illness. That means contaminated edibles, tinctures, or oils can bring more than just the munchies. ✚ In severe cases, mold exposure can lead to invasive aspergillosis. This is a life-threatening fungal infection that can spread to the blood vessels and major organs—especially in immunocompromised individuals. And the kicker? You might not even notice it. Mold on cannabis isn’t always visible to the naked eye. So, how do you spot it? How to Identify Moldy Weed (Before You Inhale a Problem) Mold can be sneaky. It doesn’t always announce itself with a dramatic puff of spores. But here are some red flags to look for: ✚ Grayish or white fuzzy spots—if it looks like your bud is growing a winter coat, that’s a problem. ✚ Dark speckles or powdery residue—could be mold, could be something worse. ✚ Musty or ammonia-like smell—cannabis should smell fresh and pungent, not like a basement after a flood. ✚ Use a black light—some molds glow under UV light. A handy trick if you’re suspicious. If any of these are present, do not smoke, vape, or consume that product. Why This Recall Happened: The Problem with Cannabis Testing The fact that moldy cannabis was able to pass lab testing and hit dispensary shelves isn’t just bad luck—it’s a systems failure. 🛑 Here’s what went wrong: ✚ Lab Shopping – Companies can choose which lab tests their product, and not all labs are equal. Some use PCR testing, which is unreliable for mold and yeast detection. ✚ No Post-Market Testing – Once a batch passes testing once, it’s never checked again. Contamination can develop later due to poor storage. ✚ Humidity and Storage Issues – Cannabis is moisture-sensitive. If stored improperly—even after testing—it can still develop mold. And it’s not just Massachusetts—some states allow up to 100 times more mold in cannabis than Massachusetts does. So, how do you make sure your stash stays safe? How to Protect Yourself: What You Can Do About Moldy Weed Since we clearly can’t always rely on testing to catch mold contamination, it’s on consumers to be proactive. Here’s how: 1️⃣ Check Your Product Before Use ✔ Inspect your flower under natural and black light—look for fuzzy spots, white powder, or dark specks. ✔ Smell it—if it smells musty, stale, or chemical-like, that’s a no-go. ✔ Break it apart and check the inside—sometimes mold is hidden deep inside the bud. 2️⃣ Store Cannabis Properly ✔ Keep humidity levels below 55%. Moisture = mold’s best friend. ✔ Use airtight glass or vacuum-sealed containers. No plastic bags! ✔ Store in a cool, dark place. Heat and light can weaken cannabinoids while encouraging mold growth. 3️⃣ Know Your Symptoms ✔ If you experience persistent coughing, wheezing, sinus pain, nausea, or fever after using cannabis, seek medical attention. ✔ If you’re immunocompromised, avoid inhaled cannabis unless you can verify its purity. Final Thoughts: Holding the Cannabis Industry Accountable This recall shouldn’t have happened—and yet, here we are. Massachusetts has some of the strictest testing regulations in the country, but if oversight isn’t enforced, those rules don’t mean much. The bottom line? Cannabis is medicine for millions, and it needs to be treated like it. So, if you’re a consumer: Check your batch numbers, demand transparency, and store your products safely. If you’re an industry professional? This recall is your sign to push for better standards. If you think testing needs to improve, drop a comment. Let’s talk about what needs to change. 🔗 CED Clinic Blog on the Historic Mass Moldy Cannabis Recall 🔗 More details on the recall in MA are here: [...] Read more...

Moldy Marijuana: The Recall That No One Saw Coming (Until They Did)

February 5, 2025When “lab-tested” doesn’t mean “safe” Contaminated Cannabis? Not Exactly the “High” People Signed Up For The Plot Twist No One Wanted Imagine dropping $50 on a beautifully packaged eighth, getting home, breaking out your favorite grinder—only to find out later that your “top shelf” flower came with a bonus strain of bacteria, yeast, and mold. Massachusetts just saw its biggest-ever cannabis recall, affecting 29 dispensaries and hundreds of thousands of products sold over 8 months before anyone caught the issue. For most people, this isn’t the end of the world. But for medical cannabis patients—especially those with weakened immune systems—this isn’t just a bad batch, it’s a serious health risk. The recall raises bigger questions: How did this happen? Why didn’t testing catch it? And what needs to change to keep cannabis consumers safe? The Science of Why Moldy Weed is a Problem (And No, Fire Won’t Fix It) 🔬 Here’s what’s actually happening under the microscope: ✚ Mold spores can survive combustion. Yes, even if you torch your bowl like a medieval dragon, the fungal hitchhikers might still find their way into your lungs. ✚ Some bacteria found in cannabis can cause foodborne illness. This means contaminated edibles might bring more than just the munchies. ✚ 20–30% of medical cannabis users are immunocompromised. That’s one in four patients potentially at risk for serious infections, lung issues, or worse. You’d think with all the required lab testing, this wouldn’t happen, right? Ah, but here’s where it gets interesting… The Real Issue: Cannabis Testing Isn’t As Reliable As You Think Let’s talk lab shopping—a practice where cannabis companies can choose which lab tests their products. Imagine if students could pick their own teachers for grading—except instead of extra credit, this is about skipping microbial screening altogether. 🔹 Some labs use PCR testing, which is unreliable for yeast and mold detection 🔹 There’s no mandatory post-market testing—if a batch passes once, it’s never checked again 🔹 Some states allow up to 100x more mold in cannabis than Massachusetts That means this isn’t just a Massachusetts problem—this is a systemic issue across the industry. The Real-World Impact: Not Just a Bad Batch, But Bad Policy Most recreational consumers won’t notice. But medical patients? This is the difference between relief and real risk. Think of the people relying on cannabis: 🌱 Cancer patients going through chemo who can’t risk infections 🌱 People with asthma or COPD whose lungs are already compromised 🌱 Transplant recipients on immunosuppressants For them, mold isn’t just a “gross” problem—it’s a hospital visit waiting to happen. What Needs to Change? (Spoiler: A Lot) So, what’s the fix? Three simple but necessary steps: ✅ Stronger lab oversight—no more sketchy, unreliable testing methods ✅ Post-market testing—just like food recalls, cannabis should be checked after it hits dispensary shelves ✅ Public batch tracking—consumers should be able to look up their product’s lab results before buying Cannabis is medicine for millions—it should be as safe as any other medicine. Where Do We Go From Here? This recall was a wake-up call. Massachusetts has some of the strictest cannabis regulations in the country, and this still happened. That means the problem isn’t regulation—it’s enforcement. If you’re in Massachusetts, check your batch numbers. If you’re in another state? Pay attention. This could be happening in your market without anyone even catching it. 🔗 Want the full breakdown? Read more here, or watch the NBC full story: https://turnto10.com/news/local/massachusetts-cannabis-products-recalled-over-potential-mold-contamination-weed-marijuana-yeast-hotline-customers-control-commission-february-4-2025 🔗 Learn More About Mold in Cannabis and How to Stay Safe [...] Read more...

Cannabis for Your Parents & Grandparents. What No One’s Telling You

February 1, 2025 Could Medical Cannabis Help Your Parents or Grandparents? Here’s What No One Is Telling You By Dr. Ben Caplan, MD There’s an unspoken crisis happening in senior healthcare right now. Most people don’t think about it—until it affects someone they love. Right now, half of Medicare enrollees take four or more prescription drugs daily. Some take far more than that. These aren’t just everyday medications—they’re opioids, benzodiazepines, and sedatives, all of which come with serious risks. 📉 200,000 seniors are hospitalized every year from falls caused by medication side effects. 📉 12,000 seniors on Medicare die from opioid overdoses annually. 📉 Many of these drugs—prescribed for pain, anxiety, and sleep—lead to dependency, cognitive decline, and long-term health consequences. But here’s something that may surprise you: 👉 Seniors make up only 15% of the U.S. population—but account for nearly 50% of all prescription drug spending. It’s a staggering imbalance. And for millions of families, it plays out in the same painful way: A parent who was once sharp and active, but now seems groggy and withdrawn. A grandparent who used to be independent, but after a fall, lost their confidence to live alone. A loved one who follows doctor’s orders, but somehow keeps needing more medications. And here’s the question few people are asking: Does it have to be this way? A Safer, Science-Backed Alternative That’s Being Ignored Medical cannabis is not a fringe idea anymore. It’s already being used by millions of seniors to manage pain, anxiety, and sleep issues—without the risks of opioids or benzodiazepines. Take Margaret, a 72-year-old retired teacher. After years of struggling with chronic pain, her doctor prescribed opioids—first a small dose, then a stronger one. Before she knew it, she was dependent on medications that left her groggy and disoriented. A year ago, she switched to a medical cannabis tincture. Now, she sleeps better, takes fewer pills, and feels sharper than she has in years. Her story isn’t unique. It’s happening to seniors across the country. A growing body of research shows that cannabis: ✅ Reduces opioid use in chronic pain patients ✅ Helps with sleep and anxiety disorders, lowering dependence on sedatives ✅ Has anti-inflammatory properties that may help with arthritis and neurodegenerative diseases Yet, many doctors still don’t discuss it as an option. Why? Because the medical system isn’t designed to embrace natural, cost-effective alternatives. Cannabis is a threat to the pharmaceutical industry’s dominance over senior healthcare. It can’t be patented. It can’t be priced at $500 per pill. And because of outdated federal laws, it’s locked out of Medicare—even in states where it’s legal. That’s why so many families never hear about it from their doctors. And it’s why so many seniors are prescribed a cascade of medications instead. How to Talk to Your Parents or Grandparents About Cannabis If you have an aging parent or grandparent struggling with pain, anxiety, or sleep, this conversation is worth having. But it’s not always easy. Here’s how to approach it: 💬 Start with their concerns. Instead of “You should try cannabis,” ask, “Are you happy with how your medications are working?” 📚 Share the science. Many seniors worry that cannabis is “unproven” or “risky,” when in reality, it’s been researched for decades—just outside of mainstream medicine. 🏥 Make it medical. This isn’t about “getting high.” It’s about finding a safer, more effective approach to common age-related conditions. 👩‍⚕️ Find the right guidance. If their doctor won’t discuss it, look for medical professionals who specialize in cannabis-based care. Most importantly—don’t wait until things get worse. If a loved one is struggling with side effects from their medications, exploring medical cannabis could be life-changing. What You Can Do Next The system won’t change overnight. Right now, Washington refuses to acknowledge medical cannabis as a solution. Big Pharma is working hard to keep it out of Medicare and mainstream healthcare. Most doctors aren’t trained to discuss it with patients. But that doesn’t mean you have to wait for the system to change. You can start today. 🔹 Check your state’s medical cannabis laws. Regulations vary widely, and knowing your options is the first step. 🔹 Join CED Clinic for the leadership in medical cannabis medical guidance. Many healthcare providers still don’t discuss cannabis—seek out professionals who do, or join CED for the best. 🔹 Learn from organizations specializing in cannabis for seniors. Groups like provide science-backed education. More seniors than ever before are taking their health into their own hands, learning about medical cannabis, and making informed choices. If you or someone you love is looking for real solutions—not just more prescriptions—there’s never been a better time to explore what cannabis medicine can offer. The science is there. The options exist. The only question is: What’s stopping you from looking into it? Less Guessing, More Feeling Better: 📖 For a comprehensive, evidence-based guide to using cannabis effectively on your own, check out The Doctor-Approved Cannabis Handbook—your go-to resource for science-backed insights and practical strategies. 📅 Book Your Consultation Today – For personalized guidance tailored to your unique needs, schedule personalized medical cannabis guidance with Dr. Caplan here and get expert support on your cannabis journey 📩 Join Our Newsletter – Stay updated on cannabis research, product recommendations, and exclusive patient insights. Sign up here. 📌 Questions? Check out our Frequently Asked Questions (FAQ) or reach out directly: Ask Dr Caplan | Email CED Clinic | 📌 Looking for patient experiences? Read real stories from people using cannabis for medical conditions. 📌 Interested in research? Explore our free Cannabis Science Library for the latest studies. Fill in The Blanks: [...] Read more...

5 Game-Changing Benefits of Pediatric Cannabis Certification

January 10, 2025New Hampshire Families Can Now Access Simplified Pediatric Cannabis Care Simplifying Pediatric Medical Cannabis Certification in New Hampshire Navigating the world of pediatric medical cannabis certification in New Hampshire can feel overwhelming for families searching for alternative care options. The process traditionally involved multiple visits to different providers, confusing paperwork, and significant time investment. Thanks to recent regulatory changes, families now have access to a game-changing solution: CED Clinic’s one-stop pediatric cannabis certification service, a simplified and streamlined experience offering care and guidance all in one place. For families exploring cannabis as a treatment for their children, understanding the steps, benefits, and legal framework is crucial. At CED Clinic, we prioritize not only clinical excellence but also education and support, ensuring you feel confident in every aspect of this journey. What is Pediatric Medical Cannabis Certification? Medical cannabis certification is a process that provides legal access to cannabis-based therapies for eligible patients. For children in New Hampshire, this process requires certifications from two licensed healthcare providers, one of whom must have expertise in the child’s specific condition. This ensures that the treatment recommendation is both responsible and tailored to the child’s medical needs. At CED Clinic, we specialize in pediatric cannabis care and provide both required certifications in a single visit, saving families time, stress, and confusion. Why Consider Cannabis for Pediatric Care? Cannabis may offer therapeutic benefits for children with a wide range of conditions, including: Autism Spectrum Disorder (ASD): Cannabis has shown promise in improving communication, reducing anxiety, and alleviating challenging behaviors such as aggression and self-injury in children with ASD, PANS, PANDAS, and other neurodivergent presentations. Severe Physical and Mental Health Challenges: These include conditions such as Obsessive-Compulsive Disorder (OCD), Oppositional Defiance Disorder (ODD), Bipolar Disorder, Depression, Anxiety, and Self-Injury. For children struggling with these challenges, cannabis may help stabilize mood, reduce distress, and improve overall quality of life. Epilepsy: Reducing seizure frequency and severity, with evidence supported by FDA-approved CBD medications like Epidiolex. Chronic Pain: Offering relief for severe, persistent pain that doesn’t respond to conventional treatments. Anxiety and PTSD: Helping to calm the nervous system and improve emotional stability in children experiencing trauma or severe anxiety. The decision to use cannabis as part of a child’s treatment plan is deeply personal and should always be guided by evidence-based recommendations and a thorough discussion of the potential risks and benefits. At CED Clinic, we ensure families feel supported and informed throughout this important decision-making process. How CED Clinic Simplifies the Process CED Clinic’s pediatric medical cannabis certification services stand out for their simplicity and effectiveness: 1. All-in-One Certification Our clinic offers both necessary provider certifications in a single visit. No need to coordinate between multiple offices or endure extended delays. 2. Comprehensive Guidance Families receive detailed instructions for completing state-required paperwork, ensuring a smooth application process for medical cards. 3. Ongoing Support We stay connected with families throughout the year, offering follow-ups, clinical guidance, and answers to any questions that may arise. The Benefits of One-Stop Pediatric Cannabis Certification Convenience: Access both providers in one location, reducing stress for families and simplifying the certification process. Expert Care: Work with experienced clinicians who specialize in cannabis medicine and bring a wealth of knowledge to your child’s care. Streamlined Process: Avoid delays and confusion with step-by-step guidance designed to make the journey smooth and hassle-free. Dedicated Expertise: Build a trusted relationship with Dr. Benjamin Caplan, a world-renowned expert in cannabis medicine and author of The Doctor-Approved Cannabis Handbook, ensuring your child receives care informed by the latest science and best practices. Pediatric Medical Cannabis Certification for New Hampshire Families If you live in New Hampshire, CED Clinic is now your go-to destination for streamlined care. Our one-stop pediatric certification service makes it easier than ever to meet state requirements while receiving the highest quality of care for your child. FAQs About Pediatric Medical Cannabis Certification Q: Is cannabis safe for children? A: While cannabis has shown therapeutic potential for certain conditions, every case is unique. Our providers carefully evaluate risks and benefits before making recommendations. Q: What are the qualifying conditions for pediatric cannabis in New Hampshire? A: Conditions include epilepsy, cancer, chronic pain, severe anxiety, and more. Contact us to discuss your child’s specific situation. Q: How often must certifications be renewed? A: For New Hampshire, pediatric cannabis certifications require annual renewals. Our clinic helps families stay on track with follow-up appointments. Book An Appointment Here New Hampshire Medical Cannabis Website CED Clinic’s Pediatric Services More About CED Clinic CED Clinic: Your Partner in Pediatric Cannabis Care CED Clinic is proud to lead the way in providing compassionate, expert care for families navigating pediatric medical cannabis certification. Whether you’re seeking relief for your child’s condition or exploring new treatment options, our team is here to guide you every step of the way. Contact us today to schedule your one-stop certification appointment. [...] Read more...

Can You Grow Your Own Medical Marijuana

January 7, 2025Sponsored Message Can You Grow Your Own Medical Marijuana Medical marijuana is becoming a household name these days. As more people discover its potential health benefits, there’s been a growing curiosity about whether it’s possible to grow your own. The short answer? Yes, but it’s a little more complicated than just planting a seed and hoping for the best. I’m here to walk you through the ins and outs so you can understand the legalities, logistics, and benefits of growing medical marijuana at home. \ Is It Legal to Grow Medical Marijuana? Understanding Medical Marijuana Laws in Your Region The rules around growing medical marijuana can vary wildly depending on where you live. Some places have embraced the idea, while others are a little stricter. For example, in the U.S., states like California and Colorado allow for home cultivation with the right medical marijuana card. On the flip side, some states don’t allow it at all, even for medical purposes. It’s important to check your local laws before you even think about starting your grow operation. Differences Between Recreational and Medical Marijuana Cultivation Laws Recreational growers often have different rules compared to those cultivating for medical purposes. Medical growers might be allowed to grow more plants or have access to specific strains designed for health conditions. Recreational cultivation, where it’s legal, usually comes with tighter restrictions. Knowing which category you fall into is key. How to Get a Permit to Grow Medical Marijuana Requirements for Obtaining a Permit Getting permission to grow medical marijuana often involves proving that you have a qualifying medical condition. Most states require a recommendation from a licensed doctor, and you’ll need to apply for a medical marijuana card. Application Process Explained Once you’ve got your doctor’s recommendation, you’ll need to fill out some paperwork. This usually includes providing proof of residency, paying a fee, and submitting your doctor’s note. After approval, you’ll receive your card or permit. Best Practices for Growing Medical Marijuana Choosing the Right Strain for Medical Use Not all cannabis strains are created equal. Some are better for pain relief, while others help with anxiety or insomnia. Indica strains are often great for relaxation, while sativas can be uplifting. Hybrid strains offer a mix of both. Setting Up Your Grow Space (Indoor vs. Outdoor) Deciding where to grow depends on your space and climate. Indoor setups give you more control over conditions but require equipment like grow lights and ventilation. Outdoor grows are simpler but rely on good weather and security. Maintaining Optimal Conditions: Light, Temperature, and Humidity Cannabis plants are picky. They thrive in specific light cycles, moderate temperatures, and humidity levels. Invest in a good grow light, monitor your environment, and adjust as needed. Growing CBD Flower with Autoflowering Strains What Are Autoflowering Strains? Autoflower strains are a special type of cannabis that transitions from the vegetative stage to flowering on its own, without the need for specific light cycles. They’re perfect for beginners. Benefits of Autoflowering Strains for Beginners Growing auto flower seeds are easy to grow and don’t require a lot of fuss. They’re forgiving if you make a mistake and grow faster than regular strains, which means quicker harvests. Space-Saving Features of Autoflowering CBD Strains Autoflowers are compact, making them ideal if you’re working with limited space. You can grow them in a small grow tent, on a balcony, or even in a closet. Challenges You Might Face When Growing Medical Marijuana Legal Penalties for Non-Compliance Growing without the proper permits can lead to fines or worse. Always double-check that you’re following the law. Common Growing Issues (Pests, Mold, Nutrient Deficiency) Even experienced growers face challenges like pests or mold. Keep an eye on your plants daily, and act quickly if something seems off. Conclusion Growing your own medical marijuana is a rewarding journey, but it’s not without its challenges. By understanding the laws, setting up a proper grow space, and choosing the right strains, you can enjoy the benefits of homegrown cannabis tailored to your needs. Do your research, follow the rules, and enjoy the process—your plants (and your health) will thank you! Sponsored link: https://www.marijuana-seeds.nl/auto-flowering-seeds End of Sponsored Message ________________________________________________________________________ [...] Read more...

Biphasic Effect of Cannabis: 5 Ways Cannabis Affects Your Brain Differently

December 31, 2024Understanding the Biphasic Effects of Cannabis on Synaptic Density The JAMA Study on Cannabis and Synaptic Density: Did They Miss the Forest for the Trees? In the endlessly buzzing chaos of modern science, studies come at us like notifications: rapid-fire, intriguing, and often half-understood. The recent JAMA Psychiatry study on cannabis and synaptic density has added its ping to the mix, claiming that heavy cannabis use reduces synaptic density in key brain regions. For anyone unfamiliar, synaptic density is a fancy way of talking about how well-connected our neurons are—basically, how much chatter our brain cells have with one another. The study’s findings sound ominous: reduced synaptic density, linked to heavy cannabis use, allegedly spells trouble for cognitive and emotional health. Headlines quickly jumped to conclusions, suggesting cannabis might quietly sabotage your brain over time. For many, this report felt like the ultimate “I told you so” moment in the long-running debate over cannabis. But here’s the thing: just like that friend who insists on telling only half the story at brunch, the JAMA study isn’t painting the full picture. Yes, the data shows reduced synaptic density in cannabis users—but what it doesn’t quite grasp is why. Is it damage? Is it dysfunction? Or is it something far more nuanced and—dare I say it—logical? Let’s dig into this and see what the brain, in all its genius, might actually be up to. The Biphasic Effects of Cannabis: A Double-Edged Sword Cannabis has captivated researchers and enthusiasts alike with its remarkable effects on the brain. But did you know its impact can vary dramatically depending on how much and how often you use it? This is what experts call the biphasic effects of cannabis—a phenomenon where acute use stimulates brain activity, but chronic or heavy use may lead to compensatory adaptations, like reduced synaptic density. Recent findings, including a groundbreaking study published in JAMA Psychiatry, show that cannabis can reduce synaptic density in chronic users. While this might seem contradictory to cannabis’ known neuroplastic benefits, understanding its dual nature provides clarity. This blog explores why this paradox occurs and how the brain adapts to cannabis use over time. What Are Biphasic Effects? The term “biphasic” describes a phenomenon where a substance elicits opposite effects depending on the dose, duration, or exposure level. In the context of cannabis: •Acute Use: Triggers a surge in neural activity, enhancing the release of neurotransmitters and increasing blood flow to key brain regions. This phase often leads to heightened sensory perception, relaxation, or bursts of creativity. •Chronic Use: Engages the brain’s natural adaptive mechanisms, prompting a reduction in synaptic proteins and activity. This downregulation leads to measurable decreases in synaptic density, particularly in areas critical for cognition and emotion. These contrasting responses reflect the brain’s attempt to maintain homeostasis—an equilibrium necessary for optimal function. Cannabis initially excites neural circuits, but prolonged exposure compels the brain to recalibrate, ensuring stability in the face of sustained stimulation. Understanding The Science Behind Biphasic Effects Acute Stimulation: Cannabis and Neuroplasticity In the short term, cannabis acts as a neural stimulant. THC, its active compound, binds to cannabinoid receptors (CB1 and CB2) in the brain, temporarily boosting synaptic activity. This is why users often report heightened creativity, relaxation, or sensory perception after consuming cannabis. Research shows acute cannabis use can even promote neuroplasticity, encouraging the growth of new synapses and potentially aiding recovery from neural injury. This phenomenon has fueled interest in cannabis as a therapeutic agent for conditions like PTSD and chronic pain. Chronic Use and Synaptic Density In contrast, the recent JAMA Psychiatry study found that chronic cannabis users had significantly reduced synaptic density, as measured by SV2A (synaptic vesicle glycoprotein 2A) binding potential. This effect was observed in brain regions critical for cognition and emotional regulation, including the prefrontal cortex and anterior cingulate cortex. Why does this happen? Chronic cannabis exposure overstimulates the brain’s cannabinoid system, prompting it to compensate by reducing synaptic proteins and activity. This adaptation helps the brain avoid overexcitement but may result in long-term structural changes. Why Reduced Synaptic Density Is Adaptive Rather than interpreting reduced synaptic density as inherently harmful, it is more accurate to view it as the brain’s adaptive response to prolonged stimulation. The brain operates under a delicate balance, maintaining homeostasis to protect itself from overactivation, which can lead to cellular stress or even neural damage. When cannabis is used chronically, its active compounds, like THC, continually stimulate the brain’s cannabinoid receptors. This prolonged activation can overstimulate synaptic circuits, akin to leaving a car engine running at full throttle for too long. Without intervention, this sustained neural “revving” could lead to overheating, inefficiency, or breakdown—manifesting in the brain as disrupted signaling or damaged synapses. To prevent such damage, the brain engages its natural protective mechanisms: •Downregulation of Synaptic Activity: By reducing the production and activity of synaptic proteins, the brain effectively “turns down the volume” on its neural circuits. This adaptation safeguards the system from burnout, preserving overall neural integrity. •Decreased Synaptic Density: This reduction isn’t necessarily a sign of harm but rather a recalibration. By decreasing the density of active synapses, the brain mitigates the potential for overstimulation. A Real-Life Analogy: Managing Overwhelming Sound Imagine you’re at a concert where the music is incredibly loud. At first, the sound is exhilarating, but over time, the sheer volume becomes overwhelming. To protect your ears from damage, you instinctively cover them or step away from the speakers. The music becomes quieter, but your hearing remains intact for future enjoyment. Similarly, the brain reduces synaptic activity to avoid overstimulation, ensuring it can continue functioning optimally in the long run. Protective Yet Imperfect While this adaptive response is protective, it can have side effects. Reduced synaptic density in critical regions like the prefrontal cortex may contribute to some cognitive and emotional challenges associated with chronic cannabis use. For example, users might experience difficulties with memory, attention, or emotional regulation as their brain recalibrates. However, this trade-off is preferable to the potential damage that unchecked neural stimulation could cause. The Conflicting Evidence: Cannabis and Brain Health The JAMA Psychiatry study, with its focus on reduced synaptic density in chronic cannabis users, presents findings that seem, on the surface, to paint cannabis in a negative light. Yet, a wealth of other research highlights its potential neuroplastic benefits—the brain’s ability to adapt, grow, and recover. This apparent contradiction has left both scientists and the public wondering: is cannabis a friend to the brain, or a foe? The answer lies in understanding the complex, biphasic nature of cannabis’ effects and the critical roles of dose and duration of use. Moderate, Acute Use: A Boost for Neuroplasticity In moderate, occasional use, cannabis has shown an ability to enhance neuroplasticity. When THC, the psychoactive compound in cannabis, interacts with CB1 receptors in the brain, it can stimulate the release of neurotransmitters, increase blood flow to key areas like the prefrontal cortex, and promote short-term synaptic connectivity. This is why many users report feelings of heightened creativity, relaxation, or sharper sensory perception after acute cannabis use. On a deeper level, this stimulation has been linked to potential therapeutic benefits: •PTSD Recovery: By promoting new neural connections and dampening overactive fear responses, cannabis shows promise in aiding recovery from trauma. •Chronic Pain Management: Enhanced neurotransmitter signaling can help disrupt pain pathways, providing relief for those with chronic conditions. •Neurodegenerative Diseases: Preliminary research suggests that cannabis could support neural resilience in conditions like Alzheimer’s or Parkinson’s disease by fostering synaptic connectivity. In these contexts, cannabis acts as a temporary enhancer, giving the nervous system a gentle nudge to adapt and rebuild. Chronic, Heavy Use: The Brain’s Protective Adaptation Contrast this with the effects of chronic, heavy cannabis use. Prolonged exposure to THC doesn’t simply stimulate the brain—it overwhelms it. The brain’s endocannabinoid system, designed to regulate processes like mood, memory, and appetite, can only handle so much external input before it needs to adapt. Here’s how the brain responds: 1.Downregulating CB1 Receptors: To prevent overstimulation, the brain reduces the number and activity of cannabinoid receptors, which decreases overall neural sensitivity to THC. 2.Reducing Synaptic Proteins: Proteins critical for synaptic activity, like SV2A, are produced in lower quantities, leading to reduced synaptic density. 3.Structural Adjustments: Over time, the architecture of synaptic connections may shift to accommodate the brain’s recalibrated signaling needs. These changes are not inherently harmful; rather, they’re part of the brain’s remarkable ability to maintain homeostasis, or balance. However, they can come with side effects, such as: •Diminished Cognitive Function: Reduced synaptic density in areas like the prefrontal cortex can affect attention, decision-making, and memory. •Emotional Dysregulation: Adaptations in the anterior cingulate cortex may contribute to feelings of apathy or emotional flatness in heavy users. This phase of cannabis use highlights the brain’s protective mechanisms. Rather than letting overstimulation run rampant, the brain effectively “turns down the volume” to preserve its integrity. Reconciling the Contradictions: Biphasic Effects in Action The seeming contradiction between cannabis’ neuroplastic benefits and its association with reduced synaptic density becomes clear when viewed through the lens of biphasic effects. Cannabis isn’t inherently “good” or “bad” for the brain; its impact depends entirely on how it’s used. •In Low to Moderate Doses: Cannabis acts as a stimulator, fostering new connections and enhancing neural activity. •In High, Sustained Doses: Cannabis triggers compensatory mechanisms, leading to downregulation and reduced synaptic density. Think of it like exercise. A moderate workout boosts your energy, strengthens muscles, and improves overall health. But overtrain, and your body starts breaking down, reducing performance to protect against injury. Similarly, cannabis provides benefits at the right dose but pushes the brain to adapt when overused. The Takeaway: Context Is Everything Understanding the biphasic nature of cannabis allows us to reconcile the conflicting findings in the literature: 1.The JAMA Psychiatry study highlights the long-term effects of chronic, heavy use, where the brain’s adaptations result in reduced synaptic density. 2.Other studies focus on the benefits of moderate, acute use, demonstrating enhanced neuroplasticity and therapeutic potential. Neither perspective is wrong—both are part of a larger, more complex story. The real challenge is educating users, clinicians, and policymakers about how dose and duration of cannabis use shape its impact on the brain. By embracing this nuanced understanding, we can maximize cannabis’ benefits while minimizing its risks. Implications for Cannabis Users Understanding the biphasic effects of cannabis is not just a scientific curiosity—it’s a practical roadmap for making informed decisions about its use. Whether you’re a casual user, a medical patient, or a clinician guiding others, recognizing how dose and duration shape cannabis’ impact can help maximize its benefits while avoiding potential pitfalls. Here are some key takeaways: Therapeutic Use Moderate, controlled cannabis use may unlock its neuroplastic benefits without pushing the brain into an adaptive overdrive. For individuals with conditions like PTSD, chronic pain, or anxiety, cannabis can support the brain’s natural capacity to heal and adapt, promoting resilience in the face of mental and physical challenges. These benefits are particularly tied to occasional or low-dose use, which stimulates cannabinoid receptors without overwhelming them. For example, a small dose of THC or CBD can help regulate sleep cycles, relieve pain, or dampen overactive fear responses without causing structural changes in the brain. The key lies in moderation—using cannabis as a tool to support overall well-being rather than as a crutch for daily stressors. Chronic Risks Prolonged, heavy cannabis use isn’t just about tolerance—it can reshape the brain’s architecture over time. When THC continuously activates cannabinoid receptors, the brain responds by reducing receptor sensitivity and synaptic density, particularly in areas critical for memory, attention, and emotional regulation. While this adaptation is protective, it may come with trade-offs, such as cognitive fog, emotional flatness, or difficulty concentrating. For example, heavy cannabis use over months or years could dampen the prefrontal cortex’s ability to manage decision-making or long-term planning. Understanding these risks doesn’t mean demonizing cannabis—it means recognizing that chronic use has distinct, measurable effects that may require balance and mindful self-regulation. Education Matters Knowledge is power, especially when it comes to navigating the complex relationship between cannabis and brain health. Understanding its biphasic effects helps users weigh the potential benefits against the risks and choose patterns of use that align with their goals and health needs. For clinicians, education means equipping patients with the tools to use cannabis effectively—explaining how low doses can enhance neuroplasticity while chronic use could prompt adaptive changes. For users, this knowledge empowers informed choices, whether that means experimenting with microdosing, taking tolerance breaks, or exploring alternatives for managing chronic symptoms. Cannabis isn’t a one-size-fits-all solution, and education ensures that everyone finds the right fit for their unique circumstances. Cannabis is a tool—neither magic nor menace. The way it interacts with the brain depends entirely on how, how much, and how often it’s used. By understanding its biphasic nature, we can use cannabis safely, effectively, and with the respect that such a powerful substance deserves. How to Apply These Findings The biphasic effects of cannabis offer a valuable framework for guiding its use, research, and therapeutic applications. By understanding how cannabis affects the brain differently based on dose and duration, we can make smarter choices about how to approach its benefits and risks. Here’s how these findings can be applied: For Clinicians Educating patients about the potential long-term impacts of cannabis is key to fostering informed use. It’s important to explain not just what cannabis can do, but how patterns of use—like high doses or chronic exposure—can lead to adaptive changes in the brain that may have unintended consequences. For example, patients using cannabis for anxiety relief should be counseled on balancing therapeutic doses with breaks to avoid tolerance or dependency. Clinicians can also guide patients in exploring different cannabinoid profiles, like CBD-dominant products, which may offer benefits without the same risks of overactivation tied to THC. For Researchers Researchers have a unique opportunity to deepen our understanding of cannabis’ therapeutic potential while addressing its risks. Investigating how different doses and durations affect neuroplasticity versus synaptic downregulation can help refine cannabis-based treatments. For example, studies could explore whether intermittent use patterns could optimize benefits without triggering adaptive changes in the brain. Researchers can also explore ways to mitigate the risks of heavy use, such as combining cannabinoids with other compounds that protect synaptic health or prevent overstimulation. These insights will not only clarify cannabis’ role in medicine but also help address the gaps in public understanding. For Users For everyday cannabis users, moderation is the golden rule. Using cannabis thoughtfully—whether for relaxation, sleep, or medical purposes—can help you enjoy its benefits without tipping into the risks of chronic overuse. For example, if cannabis helps you manage pain or anxiety, consider integrating it with other tools, like mindfulness or exercise, to avoid relying solely on it. Periodic tolerance breaks can also give your brain the chance to reset, ensuring you maintain its therapeutic effects without triggering the brain’s adaptive downregulation. The goal is to use cannabis as a supportive ally, not as an everyday default. Other Resources Learn more about the biphasic effects of cannabis: Unverified public site Biphasic effect of THC on memory Biphasic effect of cannabinoids on pain, anxiety, sleep see NIH studies on hyperemesis, see NIH studies on anxiety see NIH studies on acetylcholine in hippocampus see NIH studies on longevity and inflammation see NIH studies on anxiety in mammalian model (male different from female) Exploration of mechanism of action: Here and also Here •Explore Dr. Caplan’s guide on cannabis dosage and timing in The Doctor-Approved Cannabis Handbook. [...] Read more...

Is Cannabis a Gateway Drug? The Myth, the Science, and the Ongoing Debate

November 27, 2024Oh, the old Gateway Drug Nonsense! Cannabis has long carried the label of a “gateway drug,” a term suggesting that its use inevitably leads to harder substances like cocaine or heroin. This idea has shaped policies, stigmas, and public perception for decades. But is there science to back it up? A recent report by the Federal Research Division (FRD), prepared for the National Institute of Justice, delves into this question. The study sought to explore whether cannabis use truly paves the way for harder drug use—or if this belief is based more on fear than fact. With 70 years of experience in unbiased research, the FRD dissected decades of studies, and the results may surprise you. This blog unpacks the report’s key findings, relevance to modern medicine, and what it all means for the average person trying to make sense of cannabis in today’s rapidly evolving world. Read the Report HERE The Gateway Hypothesis: What Are We Really Talking About? The “gateway hypothesis” gained traction in 1975 when Dr. Denise Kandel proposed a sequence of drug use: starting with alcohol and tobacco, moving to cannabis, and eventually progressing to harder drugs. While the theory outlined patterns, it never claimed causation. Yet over time, the idea that cannabis causes harder drug use became deeply entrenched in public discourse. The FRD report asks an important question: Can we confirm that cannabis use leads people down this slippery slope, or are we conflating correlation with causation? Mixed Results and No Smoking Gun Here’s the big takeaway: after reviewing 23 peer-reviewed studies, the FRD found no conclusive evidence that cannabis use causes harder drug use. Associations Found but Not Proven: Some studies reported significant associations between cannabis use and other drug use, but none could definitively establish causality. Confounding Variables: Factors like socioeconomic status, peer influence, mental health, and genetics muddle the picture, making it hard to isolate cannabis as the culprit. Population-Specific Results: High-risk groups (like street youth or chronic pain patients) often show stronger associations, but their experiences don’t necessarily apply to the general population. So, while the data might whisper, “There’s a connection,” it stops short of shouting, “Cannabis is to blame!” The Realities of Modern Medicine: A Substitute, Not a Gateway? Ironically, some studies suggest cannabis may act as a substitute for harder drugs rather than a stepping stone toward them. In states with legal medical cannabis programs: Reduced Opioid Use: Cannabis availability correlates with fewer opioid prescriptions and lower opioid-related mortality rates. Public Health Implications: If cannabis provides a safer alternative to addictive opioids, its potential as a harm-reduction tool deserves serious attention. Cannabis may not open the door to heroin—but it might help close the door to the opioid epidemic. What the Science Missed Despite rigorous methodology, the report highlights limitations in the current body of research: 1. Biases in Data: Many studies rely on self-reported data, which can be influenced by memory errors or attempts to “look good” to researchers. 2. Narrow Populations: High-risk groups dominate the research, leaving the broader population underrepresented. 3. Animal Studies: While useful for understanding mechanisms, results from rats don’t always translate to humans. (Unless, of course, rats start applying for medical cannabis cards.) In short, there’s still much we don’t know—and what we don’t know can be just as important as what we do. A Dose of Reality: Context Matters One intriguing finding is the role of dose and context: Frequency of Use: Daily cannabis users are more likely to try harder drugs than occasional users. This doesn’t prove causality but suggests that frequency could amplify risks. Cultural Differences: Studies across 17 countries reveal starkly different patterns. For example, in Japan, where cannabis use is rare, few people follow the “gateway” sequence. These nuances remind us that no one-size-fits-all narrative can capture the complexity of human behavior. Why This Matters to You For the average reader, this debate may feel academic—but it has real-world implications. Whether you’re navigating medical decisions, voting on cannabis legislation, or simply trying to educate yourself, understanding the science (and its limits) empowers informed choices. Modern medicine is inching toward embracing cannabis for its therapeutic potential. But as with any tool, understanding its risks and benefits—not relying on outdated myths—is the key to using it wisely. The Final Verdict So, is cannabis a gateway drug? Based on the evidence, the answer is a cautious no. While associations exist, the science falls short of proving cannabis as a direct cause of harder drug use. Perhaps it’s time to retire the “gateway” label and focus on what the data does tell us: cannabis use is complex, context-dependent, and influenced by a host of factors far beyond a single puff. As the FRD report reminds us, it’s okay to admit we don’t have all the answers yet. Science is a journey—not a destination. And when it comes to cannabis, the road ahead is sure to be just as fascinating as the path we’ve traveled so far. That’s All! It’s easy to villainize or glorify cannabis. But the truth, as always, lies somewhere in between. If this report teaches us anything, it’s to stay curious, stay skeptical, and—most importantly—stay informed. [...] Read more...

Top 10 Insights on Dr. Lydia Kapell’s Remarkable Retirement

November 18, 2024Celebrating a Legacy and Transitioning Care for Medical Card Patients in Massachusetts Honoring Dr. Lydia Kapell, MD Dr. Lydia Kapell’s retirement marks the end of an era for Massachusetts’ medical card patients. As a compassionate and trusted provider, Dr. Kapell has dedicated her career to ensuring patients receive the highest level of care. Now, as she steps into retirement, her patients may have questions about what comes next. In this post, we’ll honor her legacy, address the transition process, and share how patients can continue their medical card care. What Dr. Lydia Kapell’s Retirement Means for Patients Dr. Lydia Kapell’s retirement is a significant moment for her patients and the Massachusetts medical cannabis community. Her decision reflects years of unwavering service, a commitment to patient well-being, and an immense contribution to accessible cannabis care. As she departs from her practice, patients should feel confident that compassionate and knowledgeable alternatives are available. Ensuring Continuity of Care After Dr. Lydia Kapell’s Retirement For patients transitioning from Dr. Kapell’s care, maintaining access to medical cannabis certifications is essential. Dr. Kapell has made arrangements to ensure her patients are supported through partnerships with trusted providers like CED Clinic, where our team is dedicated to upholding her legacy of excellence. How to Transfer Care: 1. Contact our clinic via email at info@CEDclinic.com or call 617-500-3595. 2. Book a virtual visit directly online: Click HERE 3. Learn more about CED Clinic HERE. The Legacy of Dr. Lydia Kapell Dr. Kapell’s career has been defined by her patient-first philosophy. From advocating for cannabis accessibility to personalizing care plans, her approach has set a high standard for the field. Her retirement is a time to reflect on the impact she has had on countless lives and celebrate her contributions to the Massachusetts medical cannabis community. How to Prepare for Your Certification Transfer If you are a patient of Dr. Lydia Kapell, MD transitioning your care is straightforward. Begin by gathering your medical history and certification details. At CED Clinic, we honor your prior relationship with Dr. Kapell by offering free certifications to patients who transfer during this time. This ensures a smooth handover while reducing any financial concerns. Why Choose CED Clinic? Our team at CED Clinic is passionate about providing expert care, emphasizing education, and building lasting patient relationships. By incorporating Dr. Kapell’s philosophy into our approach, we aim to offer: • Comprehensive virtual care for convenience and accessibility. • Educational resources to empower patients. • Personalized guidance tailored to each patient’s unique needs. FAQs About Dr. Lydia Kapell’s Retirement 1. Why is Dr. Kapell retiring? While Dr. Kapell is stepping back from her practice for personal reasons, her patients remain her top priority during this transition. 2. What happens to my medical card? Your medical card remains active. Simply transfer your care to a trusted provider like CED Clinic to maintain your certification. 3. How can I contact CED Clinic? Reach out to us at info@CEDclinic.com for assistance with transferring care or scheduling a consultation. Looking Ahead: Resources for Patients Post-Retirement As the medical cannabis field evolves, it’s crucial for patients to stay informed. Visit our Cannabis Knowledge Blog for the latest updates, expert advice, and resources to optimize your cannabis care journey. Conclusion Dr. Lydia Kapell’s retirement is both a bittersweet farewell and an opportunity to honor her extraordinary contributions and legacy of care. At CED Clinic, we are committed to ensuring her patients feel supported and cared for during this transition. If you’re looking for expert guidance and personalized care, we’re here to help. Suggested External Links • Massachusetts Cannabis Control Commission • Learn more about Lydia Kappell, MD Suggested Internal Links • CED Clinic Patient Resources • CED Clinic Blog: Cannabis 101 Newsletter: Cannabis and Cognition: Not the Brain Drain You’ve Been Warned About Breaking Free from Opioids: Can Cannabis Be the Answer? [...] Read more...

AI Review: The Cannabis Handbook

October 18, 2024AI just reviewed my book, The Doctor-Approved Cannabis Handbook, and it’s a must-see! In under 8 minutes, they cover cannabis science, debunk myths, and share patient stories—all in a way that’s simple and accessible. Curious? Check out the full review below! [...] Read more...

Unlock the Healing Potential of Cannabis – Audiobook!

October 10, 2024I’m thrilled to announce that *The Doctor-Approved Cannabis Handbook* is now available as an audiobook – and for a limited time, you can grab it at 70% off! 🎧 Whether you’re a seasoned cannabis user or someone who’s curious but unsure where to start, this audiobook is designed to be your go-to guide for understanding how medical marijuana and CBD can play a role in your wellness journey. As someone who’s worked with thousands of patients over the years, I’ve seen firsthand the transformative power of cannabis. From helping manage chronic pain to reducing anxiety, improving sleep, and even supporting mental health, cannabis is far more than just a recreational substance – it’s a legitimate therapeutic tool that can enhance quality of life. Unfortunately, due to stigma and misinformation, many people are still hesitant to explore its potential. That’s where *The Doctor-Approved Cannabis Handbook* comes in. In this audiobook, I break down the science behind medical cannabis, explain how to use it safely, and offer practical advice for integrating it into your daily health routine. Whether you’re dealing with chronic pain, insomnia, or simply looking for ways to improve your overall wellness, this guide covers it all. And don’t worry – while I’d love to say it’s my voice narrating, I’ll spare you the sound of my voice (trust me, my dogs wouldn’t approve 🐶). Instead, a professional narrator brings the content to life, making it easy to listen and absorb the information at your own pace. If you’ve ever wondered how cannabis could help you or a loved one, now’s the perfect time to dive in. You can listen on your commute, during a workout, or while relaxing at home – wherever and whenever it works for you. So, what’s your biggest question about using cannabis for wellness? How do you think cannabis could fit into your daily health routine? Have you ever tried CBD for stress, pain relief, or sleep? 🔗 Click here to grab your audiobook at 70% off! [...] Read more...

7 Crucial Facts About Medical Cannabis Safety for 2024

September 23, 2024Understanding the Real Impact of Cannabis on Cognition and Health 7 Crucial Facts About Medical Cannabis Safety for 2024 Medical cannabis has become a hot topic in both public and scientific discussions, particularly regarding its safety and impact on health. Medical cannabis safety is at the heart of the ongoing debate, with many patients and healthcare providers seeking clarity on its cognitive and long-term effects. A recent study sheds light on how cannabis affects the brain, cognition, and overall health, providing insights that are crucial for understanding its viability as a treatment in 2024 and beyond. The study essentially found that using medical cannabis in light to moderate amounts for a year didn’t cause any major changes in brain activity or cognitive function. Participants maintained stable memory, decision-making, and self-control without noticeable short-term side effects. However, since the study focused on a specific group, we still need more research to understand the long-term effects and how it applies to a broader population. As medical cannabis becomes increasingly available, it’s ever more important to take a careful, skeptical, look at its implications—both positive and negative—on brain function, memory, and cognitive health. Below, we’ll break down seven key facts about medical cannabis safety, exploring what this study tells us and addressing important considerations that may have been overlooked. Fact 1: Medical Cannabis Shows Minimal Cognitive Decline Over Time One of the most important findings from the study is that medical cannabis safety appears to hold up in the short term, with no significant cognitive decline observed over a one-year period of moderate cannabis use. This is reassuring for patients using cannabis to manage symptoms like anxiety, pain, or insomnia. The study participants, who were primarily light to moderate users of cannabis, showed no significant changes in brain activation during cognitive tasks such as working memory or inhibitory control. This suggests that cannabis, particularly CBD-dominant products, does not impair cognitive function when used in moderate doses by adults. However, it’s worth noting that the study’s follow-up period of just one year may not be enough to capture long-term cognitive effects, especially if users increase their dosage over time. Tolerance to THC, for instance, is well-documented, and patients may need to escalate their intake for continued symptom relief, potentially leading to cognitive challenges down the line. Fact 2: THC vs. CBD – Different Effects on the Brain The study did not focus specifically on the differences between THC and CBD, but it’s crucial to understand how these two cannabinoids interact with the brain differently. THC, the psychoactive compound in cannabis, binds to CB1 receptors in the brain, which can cause memory impairment, reduced attention, and disrupted executive function. In contrast, CBD does not have psychoactive effects and may actually counteract some of THC’s negative impacts on the brain. For medical cannabis safety, the balance between these two cannabinoids is key. Patients using CBD-dominant products likely face fewer cognitive risks than those using THC-heavy strains, especially over the long term. The Doctor-Approved Cannabis Handbook, page 36 “Cannabinoids can also have a direct eﬀect on nerve signaling, which governs thoughts, movement, and sensory function. You can think about your brain as the top of a pyramid, sending signals down that aﬀect other systems throughout the body via the nervous system. Nerve signals begin as electrical impulses in the brain, and the endocannabinoid system has a powerful effect on this network, causing a slowing down of signaling. That’s why when you are using cannabis products, particularly those products that are high in THC, you may feel like you are moving more slowly, and, more importantly, you feel calmer and less hurried. Cannabinoid molecules mimic some of the natural hormones that our bodies produce. For instance, some cannabinoid molecules have the precise shape to fit into the same receptors to which opiates and narcotics bind. Although the effect of cannabinoids binding the mu opiate receptors is only a small fraction of the intensity of opiate medicines bonding there, we still feel slight levity with the cannabinoids without the typical consequences of the addictive narcotics. In fact, many patients who have been prescribed opiates for pain relief end up using far less medication when combined with cannabis products.” Fact 3: Real-World Use vs. Controlled Lab Settings This study stands out because it was conducted in a real-world setting, meaning participants chose their cannabis products from local dispensaries, much like actual medical users. While this makes the findings more applicable to everyday users, it also introduces a level of variability that could obscure more nuanced results. Different strains, dosages, and consumption methods (e.g., vaping vs. edibles) all affect how cannabis interacts with the brain and body. Patients using cannabis for medical purposes should be aware of this variability and work closely with healthcare providers to find the right dosage and formulation for their specific needs. Standardization in medical cannabis remains a challenge, which is why regulation and ongoing research are vital to ensure medical cannabis safety across the board. Fact 4: Medical Use Is Not Recreational Use It’s important to differentiate between medical cannabis and recreational cannabis. Many of the negative cognitive effects associated with cannabis use—such as memory loss or executive dysfunction—are tied to heavy, recreational use, particularly in younger populations. In contrast, medical cannabis users are often older adults using the drug for symptom management under the guidance of a physician. The study primarily involved older, White, and well-educated participants who began using cannabis in adulthood. These findings may not apply to younger users or those who began using cannabis recreationally during adolescence, when the brain is still developing. Adolescent cannabis use is known to have more significant long-term cognitive impacts. Fact 5: Limited Applicability to Broader Populations The study’s findings are based on a specific demographic: older adults using cannabis for medical reasons. This raises questions about applicability to broader populations, including younger individuals, minorities, and heavy recreational users. Medical cannabis safety in younger populations, especially those using cannabis with higher THC content, could present more risks. For researchers and healthcare providers, this means more studies are needed that include diverse demographics, varying cannabis use patterns, and longer-term follow-up periods to fully understand the impact of cannabis across different groups. Fact 6: Potential for Long-Term Risks While the study found no significant cognitive decline over the course of a year, we must acknowledge that long-term effects may still emerge with prolonged use, especially if patients develop tolerance and increase their dosage. THC-heavy products, in particular, may lead to dependence or addiction over time, which could have lasting cognitive consequences. For healthcare providers, monitoring patient use and ensuring responsible consumption is critical to maintaining medical cannabis safety over the long term. Patients should be educated on the potential risks of dose escalation and work with their physicians to adjust their treatment plans as needed. Fact 7: The Need for Standardized Dosing and Regulation One of the challenges highlighted by this study is the lack of standardized dosing in medical cannabis. Since participants selected their own products from dispensaries, there was considerable variation in cannabinoid content and consumption methods. This underscores the need for better regulation and standardization of medical cannabis products to ensure consistent, safe use across the board. Until these standards are established, patients and clinicians must work together to find the right balance of cannabinoids and consumption methods that provide symptom relief without compromising medical cannabis safety. A Final Thought on Medical Cannabis Safety As the use of cannabis becomes more widespread, understanding its true impact on cognition and health is more important than ever. This study offers encouraging evidence that moderate use of medical cannabis may be safe for many adults, but we must remain vigilant about the long-term effects, especially in younger or heavier users. Moving forward, regulation, standardization, and patient education will be crucial to ensuring that cannabis remains a viable therapeutic option for those who need it most. Salient Statistical Points: The study revealed no significant cognitive decline among light to moderate cannabis users over the course of one year. However, it’s important to note that the participant group was primarily made up of older, White, and well-educated individuals, which limits the generalizability of the findings. Additionally, the study did not control for the cannabinoid ratios, meaning participants used cannabis products with varying balances of THC and CBD. This variability, combined with the study’s relatively small sample size, also limited the researchers’ ability to assess subgroup effects based on specific medical conditions. More on The Cognitive Effects of Cannabis Cannabis and Mental Health Impact of CB1 and cognition 5 Ways Cannabidiol Alzheimer’s Treatment Benefits Brain Health [...] Read more...

September 20, 20245 Powerful Ways to Restore Balance and Wellness in Your Life: Simple Strategies to Regain Control of Your Body and Mind In the chaos of everyday life, our bodies and minds are constantly sending signals that something may be off. Whether it’s a persistent muscle ache, frequent breakouts, or just that lingering feeling of fatigue, these are often signs that our balance and wellness are out of sync. Taking control of our health requires tuning into these signals before they snowball into larger issues. Balance and Wellness are not just buzzwords—they represent the key to living a fulfilling, healthy life. When we’re in sync, we feel better physically, emotionally, and mentally. The good news is, there are simple strategies to help restore balance and wellness in our daily routines. The Unnoticed Disruptions to Balance and Wellness Minor physical annoyances, like that stubborn pimple or the sore muscle that won’t go away, are often ignored. But these are signals that something is disrupting the body’s natural equilibrium. For example, a pimple might not just be a skincare issue but a sign of internal imbalance such as stress or poor diet. Similarly, muscle stiffness could be a reminder that you haven’t moved enough throughout the day. If we address these small signs early on, we can prevent bigger issues down the road. 1. Pay Attention to the Body’s Signals One of the easiest and most effective ways to maintain balance and wellness is to listen to your body. Your body is constantly communicating through physical discomfort, low energy levels, and mental fog. These symptoms are often the result of an underlying imbalance that needs addressing. For example, persistent muscle stiffness might suggest you’re too sedentary, while low energy could be a sign of poor nutrition. Simple fixes like taking short breaks to stretch or integrating nutrient-rich foods into your diet can go a long way in rebalancing your system. 2. Restore Balance and Wellness with Better Sleep Sleep plays a critical role in maintaining balance and wellness. When we don’t get enough sleep, our bodies miss out on essential recovery time. This leads to muscle fatigue, weakened immune function, and even mood swings. A good night’s sleep isn’t just about quantity—it’s about quality. Sleeping in awkward positions or in a disruptive environment can cause neck and back pain, leaving you feeling off for the entire day. Make sure you’re setting up a sleep routine that promotes deeper, more restful sleep. This means maintaining a consistent sleep schedule, reducing screen time before bed, and optimizing your sleep environment (think: blackout curtains and a supportive mattress). 3. Nourish Your Body with a Balanced Diet What you eat has a huge impact on your overall balance and wellness. Diets lacking in essential nutrients like omega-3 fatty acids or Vitamin D can leave you feeling sluggish and more prone to illness. On the flip side, a diet high in sugar, fat, and salt can throw your body’s internal balance into disarray, resulting in fatigue, bloating, and mood fluctuations. Integrating more fruits, vegetables, and whole grains into your diet can help stabilize blood sugar, reduce inflammation, and provide the energy your body needs to function at its best. Aiming for nutrient-dense meals throughout the day will ensure that your body receives the right fuel to maintain balance and wellness. For more information on how diet affects your overall well-being, check out our guide on the relationship between nutrition and wellness. 4. Regular Physical Activity for Body and Mind Exercise isn’t just about building muscle or losing weight—it’s about maintaining balance and wellness. Physical activity increases circulation, boosts your mood by releasing endorphins, and keeps your muscles and joints functioning properly. Even light activities like walking, stretching, or yoga can improve your overall health by reducing stiffness and improving posture. Studies have shown that regular physical activity can also help improve mental clarity and reduce stress, both of which are essential for achieving balance and wellness. You don’t need to commit to an intense fitness regimen to reap the benefits—just a little movement each day can make a huge difference. For more tips on easy ways to incorporate movement into your day, explore our article on beginner’s exercise routines. 5. Use Mindfulness and Meditation to Balance and Wellness A big part of achieving balance and wellness involves taking care of your mental health. One of the best ways to do this is through mindfulness and meditation practices. Mindfulness is the act of being present in the moment, which can help reduce stress and increase overall well-being. Meditation, on the other hand, allows you to clear your mind, focus your thoughts, and restore mental balance. Both mindfulness and meditation can be integrated into your daily routine with minimal effort. Start by setting aside a few minutes each day to sit quietly and focus on your breathing. Apps and online guides can also provide structured support to make these practices easier to implement. Incorporating Cannabis for Balance and Wellness As more research is conducted on the effects of cannabis, it’s becoming increasingly clear that the plant can play a significant role in achieving balance and wellness. Cannabis, when used responsibly, can aid in managing chronic discomfort, reducing stress, and promoting better sleep. CBD, a non-psychoactive component of cannabis, is particularly useful for those looking to reduce inflammation and achieve relaxation without the high associated with THC. Incorporating cannabis into your wellness routine may provide an extra layer of support for your body’s endocannabinoid system, which plays a key role in maintaining homeostasis (or balance) in the body. However, it’s essential to consult with a healthcare provider knowledgeable in cannabis use to determine the right dosage and method for your individual needs. Final Thoughts on Restoring Balance and Wellness Restoring balance and wellness doesn’t have to be complicated. By listening to your body’s signals, prioritizing sleep, nourishing yourself with a healthy diet, staying active, and practicing mindfulness, you can prevent minor disruptions from escalating into bigger health issues. And for those exploring alternative therapies like cannabis, the potential benefits are promising. Remember, balance and wellness are not about perfection—they’re about staying in tune with what your body needs and making small adjustments along the way. Other Recent Blogs: 5 Powerful Reasons the Gateway Drug Myth Is Wrong The Essential Role of Physician Guidance in the Cannabis Industry How Past Presidents Played the Marijuana Game Is CBD the Secret Weapon for Menstrual Pain Relief? Follow Dr Caplan on social media Book an appointment with Dr Caplan Subscribe to Dr Caplan’s Newsletter [...] Read more...

5 Powerful Reasons the Gateway Drug Myth Is Wrong

September 16, 2024Unpacking the False Link Between Cannabis and Harder Drugs 5 Powerful Reasons the Gateway Drug Myth Is Wrong The Gateway Drug Myth has long influenced public perception of cannabis, shaping policies and fueling debates. It suggests that someone’s use of marijuana will inevitably lead to harder substances like cocaine and heroin. But is this myth grounded in reality, or is it a convenient tool used by politicians and fearmongers to stoke the flames of public anxiety? You guessed it. In this post, I break down the history of the Gateway Drug Myth, the racism and political motivations that helped perpetuate it, and why it continues to linger despite overwhelming evidence disproving it. The Origins of the GatewayDrug Myth The Gateway Drug Myth was born in the mid-20th century, during a time when America faced its first heroin epidemic. Returning World War II soldiers, many of whom had developed opioid addictions during their service, created a national health crisis. Despite cannabis having no real connection to heroin addiction, the narrative “conveniently” emerged that marijuana use was a stepping stone to harder drugs. This idea was not based on any substantial evidence. Instead, it was a convenient way for politicians to lump marijuana together with more dangerous substances, allowing them to create stricter policies that targeted drug use across the board, and the particular individuals they wanted to target who were consuming. Cannabis became a scapegoat, despite its lack of real involvement in the opioid crisis. And in those days, few questioned the printed press. There was no internet to do your own research andfact check. The Role of Harry Anslinger Harry Anslinger, the first head of the Federal Bureau of Narcotics, played a key role in popularizing the Gateway Drug Myth. Interestingly, in a 1937 congressional hearing, Anslinger initially dismissed the idea that marijuana leads to heroin addiction. But by the 1950s, under pressure to curb growing drug use in America, Anslinger shifted his stance. He began to promote the idea that marijuana use could open the door to more dangerous substances like heroin and cocaine. This pivot had little to do with actual science and more to do with political necessity. Anslinger needed a way to justify the growing resources being allocated to drug enforcement. By framing marijuana as a “gateway” drug, he created a narrative that justified harsher enforcement policies. Fear and Suburban Anxiety in the 1950s The 1950s saw a surge in suburban expansion, and with it, a growing fear among white, middle-class parents about the influences their children faced. With increased freedom came rebellion, and cannabis quickly became associated with this newfound defiance among teenagers. Movies like Reefer Madness and Assassin of Youth only exacerbated these fears, showing exaggerated depictions of marijuana leading young people down a path of crime, violence, and moral decay. While these portrayals had no basis in fact, they reinforced the idea that marijuana was a dangerous“gateway” drug. For many families, the Gateway Drug Myth wasn’t just about cannabis; it represented a broader fear of youth culture and the perceived threats to the traditional family structure. The Racial Implications of the Gateway Drug Myth While suburban parents feared for their children’s futures, the Gateway Drug Myth had even more harmful implications for minority communities, particularly Black and Latino Americans. Cannabis wasn’t just framed as a dangerous drug; it was portrayed as something brought into white communities by predatory Black and Latino dealers. In congressional hearings, stories of innocent white teenagers being led astray by minority drug dealers were common. This racialized narrative played a major role in justifying a two-tiered system of enforcement. Black and Latino individuals were far more likely to be arrested for marijuana offenses, even though white Americans used cannabis at similar rates. The Gateway Drug Myth in Modern Policy Despite overwhelming evidence debunking the Gateway Drug Myth, it continues to influence modern policy. Studies have shown that while there may be a correlation between cannabis use and the use of harder drugs, this is not because marijuana is inherently a gateway drug. In fact, alcohol has a much stronger correlation with the use of harder substances. A growing body of research suggests that the Gateway Drug Myth persists not because of science but because of its political utility. It taps into deep-seated cultural fears about youth rebellion, racial mixing, and moral decay, making it an easy narrative for politicians to exploit. Modern-Day Challenges and the Future of Cannabis Policy While public opinion has shifted significantly in recent years, particularly with the rise of the medical marijuana movement, the Gateway Drug Myth still casts a long shadow. Black Americans are still disproportionately arrested for cannabis-related offenses, even in states where marijuana is legal. Meanwhile, white Americans have benefited from more lenient enforcement policies, reflecting the racial disparities that have been present since the myth’s inception. The rise of medicinal marijuana use and recent changes in state laws challenge the Gateway Drug Myth, flipping the narrative that cannabis leads to harder drugs. In fact, some states are using cannabis to help treat opioid addiction, undermining the myth at its core. Yet, these reforms often benefit middle-class white communities more than the minority communities that have historically borne the brunt of harsh drug policies. Conclusion: Putting the Gateway Drug Myth to Rest The Gateway Drug Myth has been a powerful tool in the hands of those who seek to control public perception and justify harsh drug policies. But as more research emerges, it’s clear that the myth has no real basis in science. It was born out of political necessity and has been perpetuated by racial biases and cultural fears. If we are to move forward with drug policy that is fair, evidence-based, and just, we must dismantle the myths that have shaped our understanding of cannabis for so long. The truth is, cannabis is not the gateway drug it’s been made out to be. It’s time we lay the Gateway Drug Myth to rest and address the real challenges facing our communities today. Stay Tuned for More This is just the tip of the iceberg when it comes to understanding how cannabis prohibition has been manipulated for political gain. In upcoming posts, we’ll dive into how the birth of the pharmaceutical industry, war-related propaganda, the influence of veterans, and religious crusades also played a role in shaping cannabis policy. From the rise of William Randolph Hearst’s paper empire to the DuPont family’s synthetic fibers, economic interests, and corporate manipulation also had a hand in demonizing cannabis. Stay tuned for these deeper dives into history to uncover more. Internal Links: •Human Use Of Cannabis—For Food, Fiber And Psychoactive Effects—Stretches Back Millennia, New Report Says •Disappearance of plant medicine in US history External Resources: •The Doctor-Approved Cannabis Newsletter Post On This Topic •Nixon Admitted Pot Was ‘Not Particularly Dangerous’ in Newly Uncovered Audio [...] Read more...

5 Proven Benefits of Personalized Autism Cannabis Therapy

September 9, 2024How Tailored Cannabis Therapy Provides Hope for Children with Autism At CED Clinic, we’ve worked with many families seeking alternative therapies for their children with autism, and personalized cannabis care is proving to be an effective solution. Parents often come to us after trying a range of traditional treatments that haven’t quite worked. In particular, for children with autism, finding a therapy that addresses the specific needs of the child can be a game-changer. In this post, we’ll explore 5 benefits of personalized autism cannabis therapy, and how it can dramatically improve the quality of life for children with autism and their families. 1. Personalized Cannabis Therapy for Children with Autism: A Family’s Story One of the families we worked with came to us feeling frustrated and overwhelmed by the lack of progress in their son’s behavioral treatment. Their son, who had been diagnosed with severe OCD and autism, was struggling with everyday activities like car rides, bedtime routines, and even eating. After turning to personalized cannabis care, they saw immediate improvements in his behavior, including calmness during what used to be difficult moments. Personalized autism cannabis therapy allowed their child to experience relief that conventional treatments hadn’t achieved. 2. Why Personalized Autism Cannabis Care Works Every child with autism is unique, which is why personalized care is so important. At CED Clinic, we work closely with parents to understand their child’s specific symptoms, behavior patterns, and needs. By developing a tailored cannabis plan, we can target the most challenging symptoms, such as anxiety, aggression, and sensory issues. For children with autism, this approach is particularly beneficial because it allows us to find the exact dosage and cannabis product that works best for their unique chemistry. Amazing press a patient of CED Clinic recently received: https://www.cbsnews.com/boston/news/severe-autism-life-changing-improvements-cannabis-treatment-marlboro-boy/ 3. Reducing the Dependency on Traditional Medications Many children with autism are prescribed a range of medications to manage behaviors, sensory overload, and other symptoms. Unfortunately, these medications often come with side effects or lose effectiveness over time. With personalized cannabis care, families can potentially reduce their child’s reliance on traditional medications, minimizing side effects and enhancing overall well-being. By working with families, Dr. Caplan can find the appropriate balance between cannabis therapy and existing treatments, offering an alternative that may reduce the need for heavy medications. 4. Enhancing Emotional Regulation and Behavior One of the most challenging aspects for families of children with autism is managing emotional dysregulation and unpredictable behaviors. Through the use of carefully selected cannabinoids, particularly CBD and THC in the right balance, cannabis therapy can help stabilize moods, reduce anxiety, and promote more consistent behavior. In the story shared by the family above, their son exhibited a dramatic reduction in aggressive outbursts, tantrums, and anxiety-driven behaviors after beginning his personalized cannabis regimen. This improvement allowed the family to reestablish a more peaceful routine. 5. Improving Daily Life and Family Dynamics Perhaps the most profound benefit of personalized autism cannabis therapy is the way it improves daily life for both the child and the entire family. Simple activities—like getting through bedtime, sitting through a meal, or enjoying a car ride—become possible again. For families who are used to navigating meltdowns and anxiety-laden days, these improvements are nothing short of life-changing. In the case of the family we mentioned, the son was able to calmly enjoy car rides—previously a source of significant stress. This improvement rippled through the family, bringing more peace and creating opportunities for bonding that hadn’t been possible before. Cannabis and Language Development in Children with Autism As you can see from the video above, we have observed some truly amazing results in children with autism who face extreme behavioral challenges or language obstacles. In many cases, we encounter children who initially experienced normal language development but later regressed or plateaued in their ability to build vocabulary or develop other language skills. Through personalized cannabis therapies, particularly cannabinoid-based treatments tailored to the needs of each child, we have witnessed awe-inspiring improvements in language development within this community. These therapies seem to help alleviate underlying issues related to stress, anxiety, or other neurobiological factors that may impede language acquisition. By addressing these barriers, cannabis therapy opens a door to progress that had previously been closed for many families. While every child is unique, the positive changes we’ve seen in language skills for some children have been remarkable, giving both the children and their families renewed hope for the future. If you’d like to explore whether this approach might benefit your child’s language development or overall progress, please reach out to our clinic to learn more about how personalized cannabis care could help. How to Get Started with Personalized Autism Cannabis Therapy If you or a loved one is interested in exploring the benefits of personalized cannabis care for a child with autism, the process is simple. At CED Clinic, we believe in making the experience as easy and supportive as possible. Here’s our 2-step process to get started: 1. Complete the intake form on our website to provide us with information about your child’s medical history, symptoms, and goals. Link 2. At the end of the form, you can Submit payment for your virtual visit and schedule your consultation with Dr. Caplan, who will provide you with a personalized cannabis treatment plan. Visit our appointment page to begin your journey: Book an Appointment. Final Thoughts on Personalized Autism Cannabis Therapy At CED Clinic, we believe in the transformative power of personalized cannabis care, especially for children with autism. By tailoring treatments to each child’s specific needs, we’ve been able to help countless families find the relief they’ve been searching for. If you’re curious about how cannabis might be able to help your child, don’t hesitate to reach out to our team. We’re here to support you every step of the way. You can email Jack, our clinical operations manger, anytime Testimonial From a Current Patient: Read more about cannabis care for children with special needs and how it’s changing lives. Click Here. Interview with an Autism Mom: Learn more about how one mom feels about cannabis helping her child with the challenges of autism and cannabis therapy: Link to the interview Important Note from Dr Caplan: “There is not a one-size-fits-all anywhere in cannabis care. Just like there isn’t a one-size-fits-all in human nutrition, or exercise, or sleep medicine. This philosophy extends to all aspects of patient care, where I believe in tailoring approaches to meet the unique needs of each individual. Many people try what their friends used, or ask a budtender what they’ve heard others enjoy. This is not the only option available. Expert-guided cannabis care is better.” “When it comes to introducing cannabinoids, there isn’t a single “magic formula.” It’s not like prescribing a fixed dose of medication or giving glasses to improve eyesight—this is a much more personalized process. Each person’s unique endocannabinoid system will be the primary guide. The ideal dosage, rhythm, and cannabinoids that work for someone are things I discover with a family through careful observation of the child’s responses, and which takes their real world into account. Think of it as tailoring an exercise routine—just as some athletes are sprinters and others are marathoners, we need to find out what’s best for each individual. The recommendations and guidance that I think are appropriate are meant to empower families with the knowledge to navigate this process on their own. I believe families ought to learn how to monitor progress, adjust dosages, and fine-tune care, ideally without the need for anyone supervising (eventually). I’m here to help guide patients, explain the science, and support when new situations arise—good or bad.” “This approach is different from traditional medicine. It’s a more dynamic and responsive process, which can feel unfamiliar to folks who are new to cannabis, but I believe it’s far more effective than the rigid medical systems we’ve all relied on in the past.” EDIT: Following publication of this post, we received this wonderful testimonial response about one of our autism families: (Click here) [...] Read more...

5 Powerful Reasons Why CED Clinic Is Boston’s Best Cannabis Practice

September 8, 20245 Powerful Reasons Why CED Clinic Is Boston’s Best Cannabis Medicine Practice When it comes to choosing the best cannabis medicine practice in Boston, CED Clinic stands out from the rest. With a commitment to patient care, cutting-edge research, and personalized treatment plans, we’ve earned the trust of thousands of patients across the state. In fact, CED Clinic was just awarded Best Medical Cannabis Clinic by GHP News, further solidifying our reputation as Boston’s top choice for cannabis care. At CED Clinic, we believe that cannabis medicine is about more than just providing certifications. It’s about giving patients the right guidance, education, and ongoing support to help them navigate the ever-changing world of medical cannabis. So, what makes CED Clinic the best cannabis medicine practice in Boston? Here are five powerful reasons. 1. Personalized Treatment Plans Based on Individual Needs We understand that every patient’s cannabis journey is unique. That’s why CED Clinic offers personalized treatment plans tailored to your medical condition, lifestyle, and personal goals. Our expert physicians work closely with patients to determine the best cannabis strains, products, and dosing methods that suit their specific needs. But that’s not all—every visit to CED Clinic includes some amazing extras: A free personalized shopping list with cannabis products that meet your needs. Guidance consistent with The Doctor-Approved Cannabis Handbook to ensure you receive expert recommendations based on the latest in cannabis science. Some visits even come with a free copy of The Doctor-Approved Cannabis Handbook, authored by Dr. Benjamin Caplan himself. Every patient receives complimentary access to Dr. Caplan’s The Doctor-Approved Cannabis Newsletter and a free status update on the latest cannabis products sweeping the local and national stage. These added benefits ensure that you not only receive top-tier medical cannabis care but also stay informed about the best products and developments in the industry. 2. Award-Winning Cannabis Care CED Clinic is proud to announce that we have been named the Best Medical Cannabis Clinic by GHP News as part of their prestigious Healthcare & Pharmaceutical Awards. This award highlights our dedication to providing the best cannabis medicine practice in Boston and recognizes our continuous effort to lead in the field of cannabis medicine. Our patients know they’re in the hands of the very best when they choose CED Clinic. For more details on the award, you can visit GHP News Healthcare & Pharmaceutical Awards. 3. Experienced and Compassionate Medical Team The foundation of CED Clinic’s success lies in its experienced medical team, led by Dr. Benjamin Caplan, a well-known authority in cannabis medicine. Dr. Caplan and his team take the time to listen to each patient, understand their specific needs, and craft personalized treatment plans that go beyond just certifications. This level of care is one of the reasons CED Clinic continues to be recognized as the best cannabis medicine practice in Boston. Our medical staff is highly trained and stays up-to-date with the latest cannabis research to provide patients with the best possible care. Whether you are new to cannabis or a long-time user looking to refine your treatment, our team is here to guide you every step of the way. 4. Cutting-Edge Research and Access to the Latest in Cannabis Medicine As a leader in cannabis medicine, CED Clinic stays on the cutting edge of cannabis research. Our recommendations are always backed by the latest studies and clinical data, ensuring that our patients receive the most effective, evidence-based treatments. We also have strong partnerships with cannabis research organizations, allowing us to provide patients with early access to the latest cannabis products and formulations. Whether you’re looking for help with chronic pain, anxiety, insomnia, or other conditions, you can trust CED Clinic to offer the most advanced cannabis treatments available in Boston. 5. Comprehensive Support and Education for Patients At CED Clinic, we believe that informed patients make the best health decisions. That’s why we offer an abundance of educational resources to help patients better understand cannabis medicine. From webinars and blogs to our patient newsletter, we ensure that you have the tools you need to succeed on your cannabis journey. Additionally, every patient visit comes with free updates on the latest cannabis products, trends, and research. Staying informed helps you make the best decisions for your health, and CED Clinic makes that possible by keeping you up to date. For patients who are business owners or professionals looking to get involved in the cannabis industry, Dr. Caplan offers unparalleled insight. As someone who oversees medical cannabis for one of the largest cannabis funds in the country, Dr. Caplan is well-positioned to help your business navigate the complexities of the cannabis space. Moving Forward with the Best Cannabis Medicine Practice in Boston If you’re looking for the best cannabis medicine practice in Boston, look no further than CED Clinic. From personalized treatment plans to award-winning care, CED Clinic provides the best in medical cannabis expertise. Whether you’re a new patient or someone seeking to refine your cannabis treatment, our experienced team is here to help. Suggested External Links: CED Clinic: Book Yourself An Appointment Today Complete Our Intake Form Prior to Your Appointment Suggested Internal Links: Getting Started: Your First Visit Understanding Cannabis Tolerance Dr. Caplan’s Cannabis Newsletter [...] Read more...

7 Surprising Reasons Why Cannabis Language Is Broken

September 7, 2024How We Talk About Cannabis Needs an Overhaul At CED Clinic, we’ve seen firsthand how cannabis affects people differently. One thing remains consistent, though: the language we use to talk about cannabis is broken. Cannabis language is vague, confusing, and inconsistent, which creates problems not only for patients but also for professionals, researchers, and lawmakers. In fact, we’re long overdue for an overhaul of how we describe cannabis and its effects. We use words like “one puff” or “an edible,” but what do those phrases really mean? Did you hold that puff in for a long time? Was the edible mixed well or just hastily thrown together? When the effects hit, how do you describe them? Are you “high,” “relaxed,” or “a little baked”? Our cannabis language simply doesn’t do the job of communicating these varied experiences. The way we talk about cannabis impacts everything from patient care to legal regulation. Here’s why it’s broken, and how we can fix it. Indica, Sativa, Hybrid: Labels That Don’t Always Deliver We’ve all heard terms like “Indica” and “Sativa,” but these labels don’t tell the whole story. It’s commonly believed that Indica strains are relaxing while Sativa strains are energizing. However, about 70% of people report feeling calm with Indica, while the other 30% report opposite effects. It’s like ordering decaf coffee and realizing halfway through that you’ve got the full caffeine experience. Labels like these fall short, adding to the already confusing cannabis language. We need a more consistent, scientifically grounded way to classify strains and effects. Describing Cannabis Experiences: A Game of Telephone When people describe how cannabis makes them feel, it often sounds like a game of telephone. One person might say they feel “high,” another might say “zoned out,” while someone else says they feel “relaxed.” The same word doesn’t always mean the same thing from person to person. This breakdown in communication is a core part of the broken cannabis language. One of our patients at CED Clinic once described the effects of cannabis as finally feeling “normal” after a long day of stress. They likened it to taking off a heavy backpack they didn’t know they were carrying. But how can you describe such personal experiences to someone who’s never felt it? Addiction vs. Dependency: Clearing Up Misconceptions There’s often confusion between the terms “addiction” and “dependency,” especially in relation to cannabis. Many people worry about addiction, but in reality, cannabis addiction rates are similar to caffeine addiction rates. What people often confuse is dependency—when you rely on something because it improves your quality of life. At CED Clinic, we help patients understand the difference between these terms. People develop dependencies on things that help them, like exercise, dietary routines, or even skincare products. Cannabis is no different. If it helps someone sleep, manage anxiety, or feel more balanced, regular use isn’t necessarily a bad thing. Of course, there’s a risk of overuse, but isn’t that just common sense? The Legal Jargon of Cannabis: A Maze Without a Map If the cannabis language we use to describe its effects is unclear, the legal language is even more perplexing. Each state has its own rules, and there’s little consistency from one state to the next. Terms like “possession limits” and “caregiver provisions” can mean different things depending on where you live, making it tough for consumers and professionals to stay informed. At CED Clinic, we work hard to help patients navigate these legal landscapes. But until there’s some nationwide clarity, it feels like we’re all wandering through a maze with no map in hand. The Road Forward: Improving Cannabis Language for Everyone The way we talk about cannabis has to improve if we want better patient care, clearer laws, and more productive conversations around cannabis use. We need more research, standardized language, and a consistent way to describe cannabis experiences. The key takeaway? Be more intentional with your words. Whether you’re describing how you feel after consuming cannabis or trying to understand a legal regulation, precision is essential. Cannabis is too important—medically and personally—to let the language surrounding it stay broken. To read more on this topic, check out my Substack newsletter Read more CED Clinic blogs here [...] Read more...

10 Essential Personal Hygiene Tips for a Healthier Life

September 3, 202410 Essential Personal Hygiene Tips for a Healthier Life Improve Your Well-being with These Must-Know Hygiene Practices In our busy lives, it’s easy to overlook the small yet significant habits that keep us healthy. Personal hygiene is a fundamental aspect of wellness that directly impacts our overall health. From hand washing to foot care, practicing good hygiene can prevent illness, boost your confidence, and contribute to a longer, healthier life. In this post, we’ll explore ten essential personal hygiene tips that everyone should incorporate into their daily routine. 1. Personal Hygiene Tips: The Importance of Clean Hands Did You Know? The average human hand hosts around 150 species of bacteria at any given time. The Details: Our hands are constantly in contact with various surfaces, from our phones to doorknobs, increasing the likelihood of picking up bacteria. The natural oils on our skin provide an ideal environment for these bacteria to thrive. When we touch our faces—a habit many of us do frequently—we transfer these bacteria directly onto our skin, leading to conditions like acne or more severe infections. Dr. Caplan’s Advice: To minimize the transfer of bacteria, wash your hands regularly with soap and water for at least 20 seconds. Additionally, avoid touching your face whenever possible. Keeping your skin moisturized helps maintain its natural defenses. 2. Bathroom Hygiene: A Crucial Aspect of Personal Hygiene Tips Did You Know? Flushing a toilet can propel fecal bacteria into the air, with particles reaching up to six feet. The Details: Bathrooms can be breeding grounds for bacteria, particularly after a toilet flush. These bacteria can land on surfaces like your toothbrush, towel, or other personal items, increasing the risk of contamination. Public restrooms pose an even greater risk due to the high volume of users and the surfaces that are frequently touched. Dr. Caplan’s Advice: Always close the toilet lid before flushing to reduce the spread of airborne bacteria. Store your toothbrush in a closed cabinet or use a cover to protect it from potential contamination. Regularly clean bathroom surfaces with disinfectants to maintain a sanitary environment. 3. The Role of Fungi in Personal Hygiene Did You Know? We coexist with numerous fungi, many of which are beneficial to our health. However, certain conditions can lead to fungal overgrowth. The Details: Fungi are present in the air, on surfaces, and even on our skin. Typically, they play a supportive role in protecting our skin and immune system. However, when they find warm, moist environments—such as underarms, between toes, or in groin areas—they can multiply rapidly, leading to conditions like athlete’s foot, jock itch, or yeast infections. Dr. Caplan’s Advice: Maintain hygiene in these vulnerable areas by keeping them clean and dry. After bathing, ensure that you thoroughly dry all skin folds. Wearing loose, breathable clothing and using antifungal powders or sprays can also help prevent fungal overgrowth. If you notice persistent irritation, consult a healthcare provider for appropriate treatment. 4. The Importance of Belly Button Care Did You Know? Your belly button can harbor nearly 70 different types of bacteria, making it one of the most neglected areas in personal hygiene. The Details: The belly button is often overlooked during routine hygiene practices, allowing bacteria and lint to accumulate. Over time, this can lead to unpleasant odors or even infections. Dr. Caplan’s Advice: Incorporate belly button cleaning into your regular hygiene routine, especially after activities that cause sweating. Use gentle soap and water to keep this area clean and reduce the risk of bacterial buildup. 5. Earwax: Nature’s Protective Barrier Did You Know? Earwax serves as a natural defense mechanism, helping to keep dirt and bacteria out of the ear canal. The Details: While earwax is beneficial, it can sometimes accumulate and trap bacteria, leading to blockages or infections. The type of earwax you produce—whether wet or dry—depends on genetics, and each type has its own characteristics. Dr. Caplan’s Advice: Clean your ears gently with a damp cloth and avoid using cotton swabs, which can push wax further into the ear canal. If earwax buildup becomes an issue, consider using over-the-counter ear removal drops, but be sure to follow the instructions carefully. For persistent issues, a visit to an urgent care facility for professional removal is recommended. 6. Foot Hygiene: Key Personal Hygiene Tips for Everyone Did You Know? Your feet can produce up to a pint of sweat each day, creating an ideal environment for bacteria and fungi. The Details: Warm, sweaty feet provide the perfect conditions for bacteria and fungi to thrive, leading to common issues like foot odor and athlete’s foot. Without proper care, these conditions can become chronic and difficult to manage. Dr. Caplan’s Advice: Keep your feet dry by changing socks regularly, using foot powder, and wearing breathable shoes. Washing your feet daily is essential for preventing bacterial and fungal buildup. Additionally, clean your footwear, including sandals, to maintain hygiene. Avoid public foot washing stations, especially if you are unsure of their cleanliness, to reduce the risk of infection. 7. The Significance of Oral Hygiene in Personal Hygiene Tips Did You Know? Your mouth is home to more than 700 species of bacteria, some of which can cause oral health issues if not properly managed. The Details: Oral hygiene is crucial for preventing cavities, gum disease, and bad breath. Brushing, flossing, and regular dental checkups are essential to keep your mouth healthy and free from harmful bacteria. Dr. Caplan’s Advice: Brush your teeth twice a day, floss daily, and visit your dentist regularly. Consider using an antibacterial mouthwash to further reduce harmful bacteria. Maintaining good oral hygiene is not only important for your teeth but also for your overall health. Maintaining hygiene in warm, moist areas of the body can prevent fungal overgrowth and keep your skin healthy 8. Hair and Scalp Hygiene: An Often-Neglected Area Did You Know? Your scalp produces oils that can accumulate and lead to dandruff and other scalp issues if not properly managed. The Details: Hair and scalp hygiene are often overlooked, yet they play a significant role in your overall health. Regular washing and proper hair care can prevent issues like dandruff, scalp infections, and hair loss. Dr. Caplan’s Advice: Wash your hair regularly with a suitable shampoo to remove excess oils and dirt. If you have specific scalp conditions, consider using a medicated shampoo. Avoid sharing hairbrushes and hats to reduce the risk of spreading infections. “Our hands are constantly in contact with various surfaces, making regular washing crucial to prevent the spread of bacteria.” 9. Nail Hygiene: Keeping Your Hands and Feet Healthy Did You Know? Fingernails and toenails can harbor dirt and bacteria, leading to infections if not properly cleaned. The Details: Nail hygiene is essential for preventing fungal infections and maintaining the overall health of your hands and feet. Regular trimming and cleaning can prevent the accumulation of dirt and bacteria. Dr. Caplan’s Advice: Keep your nails trimmed and clean. Use a nail brush to remove dirt from under your nails, and avoid biting your nails to reduce the risk of infection. If you notice any discoloration or other changes in your nails, consult a healthcare provider. Personal hygiene is a fundamental aspect of wellness that directly impacts our overall health 10. The Role of Sleep Hygiene in Overall Health Did You Know? Poor sleep hygiene can lead to a range of health issues, including weakened immunity, weight gain, and mental health disorders. The Details: Sleep hygiene refers to the practices and habits that promote quality sleep. Proper sleep is essential for physical and mental health, as it allows the body to repair and rejuvenate. Dr. Caplan’s Advice: Maintain a regular sleep schedule, create a comfortable sleep environment, and avoid stimulants like caffeine before bed. Prioritizing sleep hygiene can improve your overall health and well-being. “Always close the toilet lid before flushing to reduce the spread of airborne bacteria in your bathroom.” Summary: By following these 10 essential personal hygiene tips, you can meaningfully reduce your risk of infection and improve your overall health. Incorporating these practices into your daily routine is a simple yet effective way to maintain cleanliness and well-being. Quick Quiz: Did You Learn…? That your hands are home to over 150 species of bacteria? That flushing with the lid up can turn your bathroom into a germ factory? That belly buttons are cozy homes for bacteria? That earwax is actually your body’s way of protecting itself? That your feet, if not cared for, can produce a pint of sweat a day? If you answered “yes” to any of these, you’re already on your way to better hygiene. Keep those tips in mind, and here’s to a healthier, cleaner you! Proper sleep hygiene is essential for physical and mental health, allowing your body to repair and rejuvenate Internal Links: The Importance of Sleep Hygiene in Wellness Pain Management: Cannabis Oils and Their Role in Your Health External Links: Why Was Cannabis Banned Worldwide? Cannabis Tolerance Demystified: 1/12 Puff, Puff, Pause: The Real Risks of Vaping CBD Sun Smarts: Simple Tips for Sunscreen Success [...] Read more...

Finding a New Medical Cannabis Provider in Massachusetts: CED Clinic Welcomes Patients from Retiring and Deceased Doctors

August 3, 2024Finding a New Medical Cannabis Provider in Massachusetts: CED Clinic Welcomes You with Open Arms If you’re searching for a new medical cannabis provider in Massachusetts, we understand that this might be a challenging time for you. Recent changes in the availability of trusted physicians, like the retirement of Dr. Lydia Kapell and the unfortunate passing of Dr. Robert Dye and Dr. Melvin Schwartz, have left many patients feeling uncertain about their next steps. But you don’t have to navigate this journey alone. At CED Clinic, we’re here to help, with a deep commitment to caring for each individual who walks through our doors. Our Commitment to You At CED Clinic, we’re more than just a place to get your medical marijuana certification. We’re a community that cares about your well-being, your journey, and your unique story. Led by Dr. Benjamin Caplan, a compassionate physician who has overseen the care of nearly 300,000 medical cannabis patients in his career, our clinic is rooted in the belief that patient-centered care is the key to empowering health and happiness. Dr. Caplan isn’t just any doctor—he’s a leading voice in cannabis medicine, having educated hundreds of physicians across 35 countries. His book, The Doctor-Approved Cannabis Handbook, is currently being distributed internationally by Penguin Random House, helping patients and doctors alike to understand the incredible potential of cannabis as medicine. Why Patients Choose CED Clinic At CED Clinic, we’ve had the privilege of serving nearly 20,000 patients from across the U.S. and abroad, including many from Massachusetts, New Hampshire, Rhode Island, Maine, and Vermont. Our mission is to provide you with compassionate, evidence-based care tailored to your unique needs. When you join the CED Clinic family, you’re not just another patient—you’re a valued member of a community dedicated to your health and well-being. We take the time to listen, to understand your concerns, and to craft a personalized plan that empowers you to take control of your health journey. Heartwarming Patient Stories We believe that the best way to understand our commitment to patient care is through the words of those we’ve had the honor to serve. Here are two stories that have touched our hearts and remind us why we do what we do. Mary’s Journey Mary, a 65-year-old grandmother, came to us after struggling with chronic pain for years. She had tried everything—from physical therapy to prescription medications—but nothing seemed to work. When her previous medical cannabis provider retired, she was at a loss. That’s when she found CED Clinic. “From the moment I walked into CED Clinic, I felt like I was finally being heard,” Mary shared. “Dr. Caplan and his team didn’t just hand me a prescription and send me on my way. They took the time to explain how cannabis could help me, and they worked with me to find the right balance that eased my pain and gave me my life back. I’m now able to play with my grandkids, take walks in the park, and enjoy life in a way I hadn’t in years. I’m so grateful for the care and support I’ve received at CED Clinic.” James’ Transformation James, a veteran in his early 40s, came to us after years of battling PTSD and anxiety. He had been through countless providers and therapies, but nothing seemed to bring him the peace he desperately needed. When his previous cannabis doctor passed away, James was unsure of where to turn. “I was nervous about finding a new doctor who would understand my struggles,” James confessed. “But Dr. Caplan and the team at CED Clinic made me feel comfortable from the start. They didn’t just treat my symptoms—they treated me as a person. They educated me on how to use cannabis effectively, and they’ve been with me every step of the way. Today, I’m managing my anxiety better than I ever thought possible, and I owe so much of that to the care I’ve received at CED Clinic.” We’re Here for You If you were a patient of Dr. Robert Dye, Dr. Lydia Kapell, or Dr. Melvin Schwartz, we understand that transitioning to a new provider can be daunting. But at CED Clinic, we’re here to make that process as smooth and supportive as possible. We’re ready to welcome you with open arms, providing the care, education, and empowerment you need to continue your medical cannabis journey with confidence. Schedule a Consultation For more information, visit our website or contact us at info@CEDclinic.com. We look forward to meeting you, listening to your story, and helping you take the next steps toward better health and well-being. [...] Read more...

5 Surprising Benefits of Cannabidiol Anxiety Treatment

May 30, 2024Exploring the Benefits and Safety of Nano-particle CBD for Anxiety Treatment What is this All About? Anxiety disorders are some of the most common mental health issues around the world. In 2019, about 301 million people were affected by these conditions. Approximately 31.1% of adults will experience an anxiety disorder at some point in their lives. However, only about 36.9% of those suffering from anxiety disorders seek treatment, leaving a significant 63.1% untreated. Despite various treatment options, many current therapies don’t work well enough, leave some symptoms untreated, or cause unpleasant side effects. This is why new and effective treatments, such as cannabidiol anxiety treatment, are needed. One promising treatment is cannabidiol (CBD), a non-psychoactive component of cannabis. This blog explores a recent study that examined the effectiveness, safety, and pharmacokinetics (how a drug moves through the body) of a nanodispersible CBD oral solution for treating mild to moderate anxiety. Study Overview Background and Relevance The number of people with anxiety disorders is growing, and many existing treatments can lead to addiction or other serious side effects. Common treatments for anxiety, such as benzodiazepines and certain antidepressants, can be effective but are also associated with dependency, withdrawal symptoms, and other adverse effects. Cannabidiol (CBD) offers a potential alternative that may provide effective relief with fewer risks. This study aimed to evaluate how well a nanodispersible CBD oral solution works and how safe it is for treating anxiety. Specifically, the study compared the outcomes of participants who used the nanodispersible CBD solution to those who received a placebo (a substance with no therapeutic effect). Researchers used standardized measures, known for their sensitivity and reliability, to detect real differences in anxiety levels and other related symptoms between the two groups. Study Design and Methodology This phase III study, titled “Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects,” was designed as a randomized, double-blind, placebo-controlled trial, which is considered the gold standard in scientific research. In a randomized trial, participants are randomly assigned to different groups to ensure that the groups are comparable and to minimize bias. Double-blind means that neither the participants nor the researchers know who is receiving the treatment or the placebo, which helps prevent bias in reporting and assessing outcomes. A placebo-controlled trial involves one group receiving the treatment and another group receiving an inactive substance (placebo) to compare the effects accurately. The study involved 178 participants with mild to moderate anxiety disorders. These participants were randomly assigned to receive either the nanodispersible CBD solution or the placebo. The study lasted 15 weeks and included comprehensive assessments using several standardized tools. These tools included the Generalized Anxiety Disorder-7 (GAD-7) and the Hamilton Anxiety Rating Scale (HAM-A), which are widely used and validated measures for assessing anxiety symptoms. Key Measures and Comparisons – GAD-7 Scores: The GAD-7 is a brief measure that assesses the severity of generalized anxiety disorder symptoms. It is sensitive to changes in anxiety levels and can detect differences over time. – HAM-A Scores: The HAM-A is another widely used scale that measures the severity of anxiety symptoms. It provides a more detailed assessment and is often used in clinical research to evaluate treatment outcomes. Researchers collected data at the beginning of the study (baseline) and at various points throughout the treatment period. By comparing the changes in GAD-7 and HAM-A scores between the CBD group and the placebo group, the study could accurately determine the effectiveness of the CBD treatment. Comparison of the Groups – CBD Group: Participants who received the nanodispersible CBD solution showed significant improvements in their anxiety scores. The mean GAD-7 score decreased from 11.8 at baseline to 4.8 at the end of treatment. The mean HAM-A score dropped from 18.9 to 7.34. – Placebo Group: In contrast, participants in the placebo group did not show significant changes in their anxiety scores. The mean GAD-7 score remained almost the same, starting at 11.2 and ending at 11.8. Similarly, the mean HAM-A score stayed relatively unchanged, starting at 18.2 and ending at 18.9. The significant differences in scores between the CBD and placebo groups highlight the effectiveness of the nanodispersible CBD solution. The use of standardized measures ensured that these differences were accurately detected, providing robust evidence of the treatment’s efficacy. Gold Standard of Research The design of this study adheres to the highest standards of scientific research. Randomized, double-blind, placebo-controlled trials are considered the gold standard because they minimize bias, allow for clear comparisons, and provide reliable evidence of a treatment’s efficacy and safety. By following this rigorous design, the study offers strong and credible evidence that nanodispersible CBD can effectively reduce anxiety symptoms in individuals with mild to moderate anxiety disorders. Hold Up: What is Nanodispersible?! Nanodispersible refers to a formulation technology that allows a substance, such as a drug, to be broken down into extremely small particles, often at the nanoscale (typically less than 100 nanometers in size). These nanoparticles can be easily dispersed in a solution, leading to several potential benefits: Improved Solubility: Nanodispersible formulations can enhance the solubility of substances that are poorly water-soluble, making them more effective when taken orally. Enhanced Absorption: The small size of nanoparticles allows them to be absorbed more efficiently in the body, leading to better bioavailability (the degree and rate at which a drug is absorbed into the bloodstream). Targeted Delivery: Nanoparticles can be engineered to target specific cells or tissues in the body, potentially reducing side effects and increasing the therapeutic effectiveness of the drug. Controlled Release: These formulations can be designed to release the drug over a controlled period, ensuring a more consistent therapeutic effect. In the context of this study, nanodispersible cannabidiol oral solution means that the CBD has been formulated into nanoparticles that can be dispersed in a solution, enhancing its solubility, absorption, and overall effectiveness in treating anxiety. Key Findings and Takeaways Efficacy of Cannabidiol Anxiety Treatment 1. Reduction in Anxiety Scores: The study found that the group taking the CBD solution had a significant reduction in anxiety scores compared to the placebo group. The mean GAD-7 score dropped from 11.8 at the start to 4.8 at the end of the treatment in the CBD group. Similarly, the HAM-A score decreased from 18.9 to 7.34. 2. Secondary Outcomes: The study also showed improvements in secondary outcomes such as the Clinical Global Impression-Improvement (CGI-I), Clinical Global Impression-Severity (CGI-S), Patient Health Questionnaire-9 (PHQ-9), and Pittsburgh Sleep Quality Index (PSQI). This suggests that cannabidiol anxiety treatment not only helps with anxiety but also improves symptoms of depression and sleep quality. 3. Safety and Tolerability: The CBD solution was well-tolerated, and no serious side effects were reported. This highlights the safety of using nanodispersible CBD as a treatment for anxiety. Mechanisms of Action Although the study did not go into great detail about how CBD works, it mentioned that CBD interacts with various receptors and neurotransmitter systems in the body that are involved in anxiety regulation. This interaction is likely why CBD has minimal side effects. The ways in which CBD works are fairly well studied, although while we have a clear view of some of the receptors and ways that CBD impacts the body with benefit, we have only scratched the surface of a complete understanding. For anyone looking for info about the mechanism of action of CBD, try these two: 1. Pertwee, R.G., 2008. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol, and delta9-tetrahydrocannabivarin. British Journal of Pharmacology, 153(2), pp.199-215. – This paper provides an in-depth look at the pharmacology of cannabinoids, including CBD, and their interactions with CB1 and CB2 receptors in the human body. It explores the various physiological effects and mechanisms through which these compounds exert their influence. 2. Ibeas Bih, C., Chen, T., Nunn, A.V., Bazelot, M., Dallas, M., and Whalley, B.J., 2015. Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics, 12(4), pp.699-730. – This review article discusses the multiple molecular targets of CBD, including its interaction with receptors, ion channels, and enzymes. It provides a comprehensive overview of how CBD affects neurological processes and its potential therapeutic applications. Click Here to read the full book, “CBD: What Does The Science Say” Or for more books: Click Here For the full CED Clinic Library: CED Clinic Library Or the Searchable Google Drive version: bit.ly/CEDarchive Scalability and Future Potential The positive results from this study suggest that the nanodispersible CBD oral solution could be used more widely in clinical settings. Its effectiveness in treating anxiety and related symptoms indicates potential applications for other psychiatric disorders. The Details of the Findings Primary Outcome Measures GAD-7 Scores – Baseline: At the start of the study, the average GAD-7 score for the CBD group was 11.8, while the placebo group had an average score of 11.2. – End of Treatment: By the end of the treatment, the average GAD-7 score in the CBD group had dropped significantly to 4.8. The placebo group’s score remained almost the same at 11.8. – Significance: The difference in GAD-7 scores between the CBD and placebo groups was −7.02, with a p-value of <0.0001. A p-value indicates the probability that the results happened by chance. A p-value of less than 0.05 typically means the results are statistically significant. So, a p-value of <0.0001 means the reduction in anxiety symptoms in the CBD group was highly significant. HAM-A Scores – Baseline: The average HAM-A score at the beginning was 18.9 for the CBD group and 18.2 for the placebo group. – End of Treatment: The average HAM-A score in the CBD group dropped to 7.34, while the placebo group’s score remained nearly unchanged at 18.9. – Significance: The difference in HAM-A scores between the CBD and placebo groups was −11.9, with a p-value of <0.0001. This also indicates a highly significant reduction in anxiety symptoms for the CBD group. Secondary Outcome Measures CGI-I Scores – End of Treatment: The average CGI-I score at the end of treatment was much lower for the CBD group compared to the placebo group, with a difference of −2.31 and a p-value of <0.0001. CGI-S Scores – End of Treatment: The CGI-S scores showed significant improvement in the CBD group, with a difference of −1.91 and a p-value of <0.0001. PHQ-9 Scores – End of Treatment: The PHQ-9 scores, which measure depressive symptoms, decreased significantly in the CBD group with a difference of −6.77 and a p-value of <0.0001. PSQI Scores – End of Treatment: The PSQI scores, which measure sleep quality, also showed a significant reduction in the CBD group with a difference of −6.08 and a p-value of <0.0001. Limitations and Considerations Study Limitations 1. Sample Size and Duration: The relatively small number of participants and the short duration of the study may limit the generalizability of the results. Larger studies over longer periods are needed to confirm these findings. 2. Participant Heterogeneity: Participants had varying levels of anxiety and different comorbid conditions, which could influence the results. 3. Placebo Response: The potential for a strong placebo effect in anxiety studies was acknowledged, which could affect the perceived efficacy of the treatment. And, if the placebo effect is actually governed by the endocannabinoid system, which is still a subject of active debate, this poses an interesting question about whether the endocannabinoid system might be fighting against the impact of CBD, or perhaps augmenting it. 4. Long-Term Effects: The study did not evaluate the long-term effects of CBD treatment beyond the 15-week period. Applicability to Different Populations The study focused on people with mild to moderate anxiety disorders. To make these findings more applicable to a wider range of people, future research should include diverse populations with different demographic characteristics and co-morbid conditions. Summary Thoughts This study provides strong evidence that nanodispersible CBD oral solution is effective and safe for treating mild to moderate anxiety disorders. The significant improvements in anxiety, depression, and sleep quality highlight the therapeutic potential of CBD. These findings support further research into CBD for treating various psychiatric disorders, offering hope for a safer and more effective alternative to traditional anxiety medications. For more information, you can access the study here: https://bit.ly/4azwHM0 OR for mainstream media coverage about the article, click here: https://bit.ly/3R0V6Dl Read more about cannabis and mental health: here More research on the topic here An article about PTSD here Here’s a look at the overlap of cannabis and anxiety from The Cannabis Handbook, Mental Health chapter, page 123-124: Addressing Depression and Anxiety “Depression and anxiety are two of the most common reasons why people come to me for guided cannabis therapies. Cannabis does not cure either anxiety or depression, but it offers a distraction that allows you to focus on something else besides the feelings, thoughts, and cycles of negativity. At the same time that cannabinoids turn down the volume of negative stimuli, they flush the brain with neutral and positive signals, which reduces the intensity of maladaptive thought patterns. To my mind, and in the results I see with many of my patients, these two functions allow cannabis to replace the internal wiring/signaling of pain with one of joy. As a medication, cannabis restores the brain’s chemical equilibrium in ways similar to how antidepressants are designed to work. Antidepressants mimic brain chemicals or influence them. First, cannabis acts on the same systems of brain chemistry, making antidepressants more efficient. And like many depression, anxiety, and pain medications, cannabinoids stimulate neural growth so that the brain has stronger connectivity, enabling its natural chemical messengers to work more efficiently. In the future, we may discover that cannabis is in fact an effective treat- ment option on its own as it floods the brain with joy molecules, but as of this writing, it’s not clear. We do know that in addition to improving neural commu- nication, cannabis molecules act directly on the same receptors that bind to our naturally occurring chemistry of joy. The chemical structure of THC is similar to the brain chemical anandamide, which is our principal happiness molecule that activates and facilitates feelings of joy. The same brain circuitry that responds to anandamide responds to THC. Most depression and anxiety medications are used in a precise, system-specific manner, operating at a single receptor or chemical pathway; very few besides can- nabis impact more than one region of the brain, or at the same time also impact regions of the body. Cannabis can also be used to address isolated components of depression and anxiety, including lethargy, fatigue, pain, aggressive or self- injurious behaviors, and others. Think about the interlocking gears of a clock and how they connect to keep the clock running. Some traditional anxiety and depres- sion medicines may replace faulty gears with a better fitting gear, or they may help existing gears run more smoothly. Cannabis doesn’t necessarily replace the gears themselves, but it extends their access in a way that still creates the desired effect. Cannabis also seems to smooth out areas of rust so that the clock continues to work well. In this way, cannabis both facilitates the interaction of all the gears to work synergistically (the whole brain) or works on just one gear. One well-known problem with antidepressants is that the ramp-up time for these medications is very long: it can take up to six to eight weeks for anxiety and depression medications to start working. That is not the case for cannabis, where the ramp up can be as quick as two weeks to achieve a steady balance. For those suffering from acute anxiety or depression, that immediacy has tremendous value. Unlike traditional antidepressants, cannabis is not associated with weight gain, reduced sex drive, hormonal disruption (acne, mood swings), or sleep disturbances. In fact, it can improve all of these conditions, which you’ll see throughout the book. Some medications used to treat anxiety, like benzodiazepines—Xanax, Valium, Ativan—are not only dangerous and addictive; they’re very short-acting. As satisfying as these quick-acting options are, the medications are rapidly habit forming and easily hit a level of tolerance, incurring a need for steadily increasing dose requirements. Despite the popular and misinformed rumor, cannabis is not any more addictive than caffeine. While I commonly see patients who use canna- bis regularly for improving their mental health, rarely does it interfere with the rest of their daily lives. Using cannabis as a therapy in the presence of a healthy environment enhances your ability to improve mood, and over time, your mood may become consistently more relaxed and positive. As my patients ramp up on cannabis, they can work with their doctors to lower the amount of other depression and anxiety prescription medications—or drop them entirely.” For More, consider picking up a copy at your local library or wherever books are sold. References The references for this blog are drawn from the original study published in the Asian Journal of Psychiatry and other peer-reviewed sources cited within the study. For detailed citations, please refer to the original publication and supplementary materials Below are 10 references from the study “Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects- A double blind multicenter randomized clinical trial“: Atakan, Z., 2012. Cannabis, a complex plant: different compounds and different effects on individuals. Ther. Adv. Psychopharmacol. 2, 241–254. Bandelow, B., Michaelis, S., 2015. Epidemiology of anxiety disorders in the 21st century. Dialog-. Clin. Neurosci. 17, 327–335. Barry, M.J., Nicholson, W.K., Silverstein, M., Coker, T.R., Davidson, K.W., Davis, E.M., Donahue, K.E., Jaen, C.R., Li, L., Ogedegbe, G., Pbert, L., Rao, G., Ruiz, J.M., Stevermer, J., Tsevat, J., Underwood, S.M., Wong, J.B., US Preventive Services Task Force, 2023. Screening for anxiety disorders in adults: US preventive services task force recommendation statement. JAMA 329, 2163–2170. Berger, M., Li, E., Rice, S., Davey, C.G., Ratheesh, A., Adams, S., Jackson, H., Hetrick, S., Parker, A., Spelman, T., Kevin, R., McGregor, I.S., McGorry, P., Amminger, G.P., 2022. Cannabidiol for treatment-resistant anxiety disorders in young people: an open-label trial. J. Clin. Psychiatry 83. Blessing, E.M., Steenkamp, M.M., Manzanares, J., Marmar, C.R., 2015. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics 12, 825–836. Brody, T., 2016. Clinical trials: study design, endpoints and biomarkers, drug safety, and FDA and ICH guidelines. Academic press. Busner, J., Targum, S.D., 2007. The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont) 4, 28–37. Buysse, D.J., Reynolds, C.F., 3rd, Monk, T.H., Berman, S.R., Kupfer, D.J., 1989. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28, 193–213. Crippa, J.A., Derenusson, G.N., Ferrari, T.B., Wichert-Ana, L., Duran, F.L., Martin-Santos, R., Simoes, M.V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Santos Filho, A., Freitas-Ferrari, M.C., McGuire, P.K., Zuardi, A.W., Busatto, G.F., Hallak, J. E., 2011. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J. Psychopharmacol. 25, 121–130. Crippa, J.A., Guimaraes, F.S., Campos, A.C., Zuardi, A.W., 2018. Translational investigation of the therapeutic potential of cannabidiol (CBD): toward a new age. Front Immunol. 9, 2009. [...] Read more...

7 Surprising Benefits of Terpenes in Cannabis Medicine

May 29, 2024Unveiling the Hidden Potential of Terpenes in Cannabis Medicine Cannabis has long been celebrated for its therapeutic benefits, with most attributing its effects to the well-known cannabinoids, THC and CBD. However, there exists a class of compounds within cannabis that has been present since the dawn of time and holds significant biological potential yet remains under-appreciated by the medical establishment—terpenes in cannabis medicine. These aromatic compounds, numbering in the hundreds, not only contribute to the distinctive smell and flavor of cannabis but also exhibit promising medicinal properties. A recent study, titled “Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors,” highlights the powerful antinociceptive (pain relieving) effects of terpenes, providing new insights into their potential therapeutic applications. Understanding Terpenes and Their Current Realities Terpenes in cannabis medicine are volatile compounds found in many plants, including cannabis. They are responsible for the distinctive aromas of different cannabis strains and have been used in traditional medicine for centuries. Despite their historical use, the medical establishment has largely overlooked their therapeutic potential, focusing primarily on cannabinoids. However, recent research is beginning to uncover the significant role that terpenes can play in pain management and other therapeutic areas. What does “Terpene” even mean? Did you know? Terpenes are fascinating compounds that serve as the fundamental building blocks of many natural substances. Simply put, a terpene is any carbohydrate molecule with a series of carbon atoms. Like the word “shape,” which can describe an array of forms such as squares, triangles, and circles, “terpene” signifies a vast variety of compounds found throughout nature. These molecules are integral to the structure and function of countless living organisms. In the context of cannabis medicine, terpenes are the aromatic compounds responsible for the plant’s distinctive smell and flavor. While they were once believed to only contribute sensory characteristics like aroma and taste, recent studies have revealed their significant medicinal properties. This paper helps us see precisely how powerful and impactful these terpenes really are in medicine, highlighting their potential to revolutionize therapeutic applications. Key Takeaways from this Study on Terpenes The study “Terpenes from Cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2A receptors” brings us a few amazing findings: 1. Pain Relief Comparable to Morphine: Terpenes from Cannabis sativa, that includes examples such as geraniol (think the smell of a geranium and the smell of roses), linalool (think lavender and its smell and suggested powers of wellness), α-pinene (think pine needles and the smell of forest), α-humulene (think woody, earthy, slightly spicy, as in hops, cannabis, sage, ginseng) and β-caryophyllene (think spicy, woody, and peppery, found in black pepper, cloves, hops, rosemary). In this study, just like in previous ones, these terpenes have shown remarkable pain relief in both humans and animals. In mice with chronic pain, the terpenes provided pain relief that was on par with morphine and the synthetic cannabinoid WIN55,212. 2. How They Work: The study found that terpenes help reduce pain by targeting the adenosine A2A receptor (A2AR). Lab tests showed that these terpenes activate this specific receptor directly. 3. Better with Morphine: When terpenes were used together with low doses of morphine, they provided even better pain relief. This suggests that combining them could reduce the need for higher doses of opioids and their side effects. 4. No High: Unlike opioids, terpenes didn’t cause a “high” or addictive behavior in the tests, indicating a lower potential for abuse. 5. Multiple Targets: The pain-relieving effects of terpenes were blocked when the cannabinoid receptor 1 (CB1) was inhibited, showing that terpenes work on multiple important receptors to relieve pain. For example, imagine the CB1 receptor as a lock on a door that helps reduce pain when unlocked. Terpenes can unlock this door to let the pain relief in. However, if you use a special key (an inhibitor) to lock this door, the terpenes can’t get through, and the pain relief doesn’t happen. This tells us that terpenes rely on more than one door (receptor) to provide pain relief, making them versatile and potentially more effective in managing pain. Wait a Minute, Is This Study Mousy? Does that even matter? The researchers used an animal model to study the effects of terpenes from Cannabis sativa. Simply put, they conducted their experiments on CD-1 mice. Mice are commonly used in scientific studies because their genetics are consistent and well-understood by scientists. Using an animal model is a crucial part of research as it allows scientists to control the environment and variables, helping them understand how things work before moving on to human testing. This way, they can gather a lot of valuable information about how terpenes might help with pain relief and other issues, potentially leading to new treatments for people. However, using mouse models has its downsides. Mice have different physiological and genetic makeups compared to humans, so results seen in mice don’t always translate directly to humans. For example, a compound that works well in mice might not be as effective in humans or might have different side effects. Additionally, mice can’t fully replicate the complexity of human diseases, especially chronic conditions and the multifaceted nature of pain in humans. These differences highlight the need for further research and clinical trials in humans to confirm the findings from mouse studies and ensure that potential treatments are safe and effective for people. Study Type This was an experimental animal study using CD-1 mice to look at how terpenes relieve chronic neuropathic pain. The results are promising, but further clinical research is required to see if they translate to human treatments. Exploring the Mechanisms and Therapeutic Potential of terpenes in cannabis medicine The study closely examined how these terpenes work, revealing their interaction with the adenosine A2A receptor. Lab tests and experiments using a specific A2A receptor blocker called istradefylline, along with targeted genetic techniques, provided strong evidence for this mechanism. Additionally, the terpenes showed significant anti-inflammatory activity, suggesting another way they might help relieve pain. Viability as a Treatment Methodology The findings of this study highlight the potential of terpenes in cannabis medicine as an effective treatment for chronic neuropathic pain. By activating the A2AR and reducing inflammation, terpenes could offer a new approach to pain management. The study also showed that when terpenes were combined with morphine, they provided even better pain relief, suggesting they could help reduce opioid dependency and the risks that come with it. Interaction with Morphine The interaction between terpenes in cannabis medicine and morphine is particularly significant. The study showed that all the tested terpenes enhanced the pain-relieving effects of morphine in chronic neuropathic pain models. This suggests that terpenes can boost the effectiveness of morphine, paving the way for combination therapies that could improve pain management and reduce the need for high doses of opioids. For example, imagine a patient suffering from chronic neuropathic pain who is currently being treated with morphine. While morphine is effective, it comes with a host of side effects and risks, including dependency and tolerance, which often require increasing doses to achieve the same level of pain relief. By incorporating terpenes into the treatment plan, the patient could potentially achieve the same, or even better, pain relief with a lower dose of morphine. This combination could not only enhance pain control but also minimize the adverse effects associated with high-dose opioid use. In practical terms, a doctor might prescribe a lower dose of morphine along with a terpene-rich cannabis extract. The terpenes, by enhancing the pain-relieving properties of morphine, could allow the patient to experience effective pain relief while reducing the overall opioid load. This approach could significantly decrease the likelihood of developing opioid dependency and other related side effects, ultimately leading to a safer and more effective pain management strategy. Did you read the other recent blogs about cannabis oil and pain relief? Check out cannabis oil for chronic pain here. Or check out cannabis and opioids here Confidence in the Mechanism of Action The study offers strong evidence that terpenes reduce pain by interacting with the adenosine A2A receptor. The adenosine A2A receptor is a protein found on the surface of certain cells throughout the body, including in the brain, heart, and immune system. It plays a key role in regulating various physiological processes, such as pain perception and inflammation. It works by binding to adenosine, a naturally occurring molecule in the body, which then triggers a series of cellular responses that can modulate pain and inflammatory signals. These findings match up well with other research showing the A2A receptor’s role in managing pain, which boosts confidence in the explanation of this study. However, more research, including clinical trials with humans, is needed to confirm and fully understand these results, particularly has these effects change with things like the environment, our genes, and social factors. How Do Terpenes Interact with Opiates for Pain Relief? The study suggests a few ways that terpenes and opioids might work together to relieve pain: Synergistic Effects: Terpenes combined with morphine can enhance pain relief Receptor-Mediated Interactions: There might be some interaction or modulation between the signaling pathways of their respective receptors. Anti-Inflammatory Effects: Both terpenes and opioids have anti-inflammatory properties, which could work together to reduce inflammation Differential Receptor Activation: Terpenes and opioids might complement each other by activating different receptors to modulate pain. Study Limitations The study acknowledges several limitations, including: Analgesic Tolerance: Lack of direct measurement of analgesic tolerance to A2AR agonists. Translational Features: Need for further investigation of dosing routes and bioavailability. Reward Liability Testing: Limited exploration of the affective properties of terpenes. Clinical Translation: Necessity for additional clinical studies to evaluate safety and efficacy in humans. Applicability to Humans While the study gives valuable insights from preclinical tests, it doesn’t discuss in detail how these findings apply to humans. More research, including studies on how the body processes terpenes and clinical trials, is needed to understand their potential benefits in human pain management. Wrapping This Up, Applying it to The Real World This study highlights the often-overlooked potential of terpenes in cannabis medicine. By elucidating their mechanisms of action and demonstrating their synergistic effects with morphine, this research paves the way for developing novel pain management therapies that could reduce opioid dependency and improve patient outcomes. As the medical community continues to explore the therapeutic applications of cannabis, terpenes may emerge as a critical component in the future of pain management and beyond. Prevalence of Terpenes: Terpenes are incredibly prevalent in nature, found in a wide variety of plants beyond cannabis, including fruits, vegetables, and herbs. These aromatic compounds are responsible for the distinct smells and flavors of many plants, such as the citrus scent of oranges, the refreshing aroma of pine trees, and the soothing fragrance of lavender. The sheer abundance and diversity of terpenes make them an accessible and versatile resource for medicinal purposes. Potential of Plant Medicine and terpenes in cannabis medicine: The findings of this study underscore the significant opportunity for plant medicine to support, and potentially compete with, the efficacy of traditional anti-inflammatories. Terpenes, with their demonstrated anti-inflammatory properties, present a natural alternative to synthetic drugs like NSAIDs (non-steroidal anti-inflammatory drugs). NSAIDs, while effective, often come with side effects such as gastrointestinal issues and increased risk of cardiovascular problems. In contrast, terpenes could offer a safer, plant-based option for managing inflammation and pain. Synergy with Traditional Treatments: Furthermore, the study’s evidence of synergistic effects when terpenes are combined with morphine highlights the potential for integrated treatment approaches. By enhancing the pain-relieving effects of opioids, terpenes could allow for lower doses of these potent drugs, thereby reducing the risk of dependency and adverse effects. This synergy not only promises more effective pain management but also aligns with a growing interest in complementary and integrative medicine. Broader Implications for Pain Management: As research continues to uncover the therapeutic benefits of terpenes, their role in pain management could expand significantly. Terpenes’ ability to interact with multiple receptors and pathways in the body suggests a multifaceted approach to pain relief, addressing both nociceptive and inflammatory pain. This could lead to more personalized and holistic treatment strategies that leverage the natural compounds found in plants. Economic and Environmental Benefits: Beyond the health benefits, the increased use of terpenes in medicine could have positive economic and environmental impacts. Cultivating terpene-rich plants for medicinal purposes supports sustainable agriculture and reduces reliance on synthetic pharmaceuticals. This shift could lead to more eco-friendly production processes and a reduced environmental footprint for the healthcare industry. Future Directions The promising results from this study should encourage further exploration into the clinical applications of terpenes. Future research should focus on conducting comprehensive clinical trials to confirm the safety and efficacy of terpenes in human subjects. Additionally, studies should investigate the optimal methods for extracting and administering terpenes to maximize their therapeutic benefits. As the landscape of medical treatment evolves, the integration of terpenes and other plant-based medicines into conventional healthcare could revolutionize how we approach pain management and inflammation. By embracing the potential of these natural compounds, we can look forward to a future where plant medicine plays a central role in promoting health and well-being. References for Further Reading: 1.Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344-1364. 2.Cox-Georgian, D., Ramadoss, N., Dona, C., & Basu, C. (2019). Therapeutic and Medicinal Uses of Terpenes. In Medicinal Plants (pp. 333-359). Springer, Cham. 3.Blaskovich, M. A. (2016). Antibiotics: from chemical warfare to anti-infective therapeutics. Advances in Pharmacology, 73, 3-32. 4.Maida, V., & Daeninck, P. J. (2016). A user’s guide to cannabinoid therapies in oncology. Current Oncology, 23(6), 398-406. 5.ElSohly, M. A., & Slade, D. (2005). Chemical constituents of marijuana: The complex mixture of natural cannabinoids. Life Sciences, 78(5), 539-548. 6.McPartland, J. M., & Russo, E. B. (2001). Cannabis and cannabis extracts: greater than the sum of their parts? Journal of Cannabis Therapeutics, 1(3-4), 103-132. 7.Pertwee, R. G. (2006). The pharmacology of cannabinoid receptors and their ligands: an overview. International Journal of Obesity, 30(S1), S13-S18. 8.Parker, L. A., Rock, E. M., & Limebeer, C. L. (2011). Regulation of nausea and vomiting by cannabinoids. British Journal of Pharmacology, 163(7), 1411-1422. 9.Booz, G. W. (2011). Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radical Biology and Medicine, 51(5), 1054-1061. 10.Hill, K. P. (2015). Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: a clinical review. JAMA, 313(24), 2474-2483. [...] Read more...

5 Essential Breakthroughs in Cannabis Neuromodulation

May 18, 20245 Essential Breakthroughs in Cannabis Neuromodulation Imagine a world where a simple plant could revolutionize the way we treat some of the most challenging health issues, from anxiety and depression to Alzheimer’s and Parkinson’s disease. Cannabis, a plant often surrounded by controversy, is showing promise in the field of neuromodulation—how it can help regulate and improve brain function. This review highlights exciting research from the study “Phytocannabinoids in Neuromodulation: From Omics to Epigenetics” to uncover how cannabis compounds might be a game-changer for brain health. To read the full paper: Click Here Key Background Recent advances in science have revealed that cannabis compounds, known as phytocannabinoids, have the potential to significantly impact our brains. These natural compounds could offer new ways to treat a range of neurological conditions by interacting with our body’s complex systems. Just like exercise, nutrition, and sleep play vital roles in maintaining our overall health, cannabis compounds can influence the body’s physiological balance. Exercise boosts endorphins, nutrition provides essential nutrients, and sleep aids in recovery and cognitive function. Similarly, phytocannabinoids interact with the endocannabinoid system to help regulate mood, pain, and neuroprotection, suggesting that cannabis might be an integral part of maintaining and improving health. What are phytocannabinoids? Phytocannabinoids are naturally occurring compounds found in the cannabis plant. They interact with the body’s endocannabinoid system, influencing various physiological processes and potentially providing therapeutic benefits for conditions like anxiety, depression, and neurodegenerative diseases. What is Neuromodulation? Cannabis neuromodulation is the process by which neurotransmitters or other chemicals in the brain regulate and influence the activity of neurons. This can include enhancing or diminishing the strength of signals between neurons, altering how they communicate, and ultimately affecting how we feel, think, and behave. Phytocannabinoids, such as CBD and THC, can act as neuromodulators by interacting with various receptors in our brain and body. What are Metabolomics and Transcriptomics? Metabolomics is the study of the chemical processes involving metabolites, which are small molecules that are part of the metabolism. By analyzing metabolites, scientists can get a snapshot of the physiological state of a cell or organism, helping to understand how different factors affect health and disease. Transcriptomics is the study of the complete set of RNA transcripts produced by the genome under specific circumstances or in a specific cell. This helps researchers understand gene expression patterns and how they are regulated, providing insights into how cells respond to different conditions. This New Study, Key Findings The study looks at how two main cannabis compounds, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), interact with our bodies. Below are the bottom-line key points: How Phytocannabinoids Work Variety in Cannabis Strains: Different cannabis strains have different effects because they have different mixes of compounds. These compounds interact with receptors in our bodies, not just CBD and THC, but others like cannabinol and Δ8-tetrahydrocannabinol. Impact on the Brain: Phytocannabinoids interact with receptors in our brain and body to help with conditions like epilepsy, depression, and Parkinson’s disease. They affect various pathways in our brain, such as ErbB and PI3K-Akt signaling, which are important for brain health. This is relatively new information, not yet incorporated into common knowledge Medicine. Personal Differences: The effects of phytocannabinoids can vary based on factors like sex, age, and health condition, which means treatments need to be personalized. Each of us has a wide range of invdividual differences, and because the cannabis industry curently offers products that are often very different, batch to batch, the combination of these two complex scenarios makes for an incredibly complex puzzle to understand the nuanced effects of cannabis products on human health. Simplified Key Findings Table Aspect Key Findings Variety in Cannabis Products Different strains have different mixes of compounds affecting their use. Impact on the Brain Interaction with brain receptors helps improve conditions like epilepsy and depression. Phytocannabinoid Targets Affect important brain pathways related to neurodegenerative diseases. Personal Differences Effects vary by sex, age, and health, needing personalized treatment plans. How They Help Neurological Conditions Conditions Addressed (a small sample of the major conditions. See here for a full view) Condition Phytocannabinoid Effects Epilepsy CBD helps reduce seizures and protects brain cells. Depression CBD can help improve mood by interacting with serotonin receptors. Parkinson’s Disease Phytocannabinoids can improve movement and reduce brain inflammation. Alzheimer’s Disease CBD can reduce brain plaque and inflammation, improving memory and cognitive function. Multiple Sclerosis CBD and THC can reduce muscle spasticity and pain. Chronic Pain CBD and THC can reduce pain by interacting with pain receptors in the brain. Anxiety Disorders CBD can reduce anxiety by modulating the brain’s response to stress. Cancer-related Symptoms CBD and THC can reduce nausea, vomiting, and pain associated with cancer and its treatment. Inflammatory Bowel Disease CBD and THC can reduce inflammation in the gut, alleviating symptoms of Crohn’s disease and ulcerative colitis. Insomnia CBD can improve sleep quality and reduce symptoms of insomnia. Post-Traumatic Stress Disorder (PTSD) CBD can reduce anxiety and improve sleep in PTSD patients. Autism Spectrum Disorders CBD can help reduce symptoms such as anxiety, aggression, and hyperactivity. Schizophrenia CBD can reduce psychotic symptoms and improve cognitive function. Migraines CBD and THC can reduce the frequency and severity of migraine headaches. Glaucoma THC can reduce intraocular pressure, alleviating symptoms of glaucoma. Arthritis CBD and THC can reduce inflammation and pain in joints affected by arthritis. Fibromyalgia CBD can alleviate widespread pain and improve sleep quality in fibromyalgia patients. Lupus CBD can reduce inflammation and modulate the immune system, helping manage symptoms of lupus. Osteoporosis CBD can support bone health and reduce bone loss. Opioid Dependence CBD can reduce cravings and withdrawal symptoms in individuals recovering from opioid addiction. (See below for references for these) How Phytocannabinoids Work in the Body Receptor/Pathway Role in Neuromodulation Phytocannabinoid Interaction Potential Therapeutic Effects Associated Conditions CB1 Receptors Help control neurotransmitter release and brain signaling. THC, CBD Pain relief, reduction in anxiety, appetite stimulation Chronic pain, anxiety disorders, cachexia CB2 Receptors Modulate immune response and inflammation. THC, CBD Anti-inflammatory effects, immune system regulation Autoimmune diseases, chronic inflammation GPCR (G-protein coupled receptors) Involved in various brain signaling pathways that protect neurons. CBD Neuroprotection, reduction of oxidative stress Neurodegenerative diseases, stroke Ion Channels (TRPV1, TRPV2, etc.) Affect how neurons send signals and perceive pain. CBD, THC Pain relief, reduction of inflammation, improved mood Neuropathic pain, arthritis, depression PPAR Receptors (Peroxisome proliferator-activated receptors) Help reduce inflammation and protect neurons. CBD, THCV Anti-inflammatory effects, neuroprotection, regulation of lipid metabolism Alzheimer’s disease, diabetes, obesity 5-HT1A Receptors (Serotonin receptors) Modulate mood, anxiety, and depression. CBD Reduction in anxiety and depression symptoms Anxiety disorders, depression Adenosine Receptors Regulate sleep, arousal, and inflammation. CBD Promotion of sleep, reduction in inflammation, neuroprotection Sleep disorders, chronic pain, epilepsy GPR55 Involved in bone density and blood pressure regulation. CBD Regulation of blood pressure, bone density maintenance Hypertension, osteoporosis GPR18 Modulates immune response and inflammation. CBD Anti-inflammatory effects, immune system modulation Autoimmune diseases, inflammation GPR119 Affects glucose homeostasis and lipid metabolism. CBD, THCV Regulation of blood sugar levels, potential weight loss Diabetes, obesity GABA Receptors Inhibit neuronal excitability and promote relaxation. CBD, THC Reduction in anxiety, muscle relaxation, anticonvulsant effects Epilepsy, anxiety disorders, muscle spasms Dopamine Receptors Modulate reward, pleasure, and motor control. CBD, THC Improvement in mood, reduction in addictive behaviors, enhancement of motor control Addiction, Parkinson’s disease Vanilloid Receptors (TRPV1) Involved in pain sensation and modulation of body temperature. CBD, THC Pain relief, reduction in inflammation, temperature regulation Chronic pain, arthritis, fever, appetite Mu-Opioid Receptors Play a role in pain relief and reward. THC Pain relief, potential reduction in opioid dependency Chronic pain, opioid addiction Sigma Receptors Influence neuroprotection and modulation of neurotransmitters. CBD Neuroprotection, potential antidepressant effects Neurodegenerative diseases, depression Personalized Medicine and Variability This study emphasizes that personalized treatment is essential because people respond differently to phytocannabinoids. Factors like sex, age, and health conditions can influence how well these compounds work, so treatments need to be tailored to each individual. Why Personalized Treatment is Important Phytocannabinoids interact with the body’s endocannabinoid system, which varies greatly from person to person. This system regulates numerous physiological processes such as mood, pain sensation, appetite, and immune function. Because of this complexity, a treatment that works well for one person might be less effective or even problematic for another. Personalized medicine aims to optimize the therapeutic benefits of phytocannabinoids by considering these individual differences. Sex Differences: Men and women may have different endocannabinoid system responses due to hormonal variations. For example, estrogen can influence how women respond to cannabinoids, potentially making them more sensitive to THC. This means women might experience stronger effects from smaller doses, necessitating careful dose adjustments. This also means that cannabinoids will interact with hormones as they change (both the hormones as they change over time and the different cannabinoids we might take) Age: As we age, our endocannabinoid system undergoes changes. Older adults tend to have a different receptor density or altered metabolic pathways, which can affect how their bodies process phytocannabinoids. For the most part, as adults age, our endocannabinoid tone wanes over time (and so, older adults stand more to gain by cannabinoids than those who are younger). This can influence the efficacy and safety of treatments, requiring age-specific dosing and monitoring. Health Conditions: Existing health conditions, such as liver disease, diabetes, or chronic pain, can affect how the body metabolizes and responds to cannabinoids. For example, individuals with liver disease may metabolize THC more slowly, leading to prolonged effects and a higher risk of side effects. Similarly, patients with chronic pain might require higher doses to achieve relief but must be monitored closely to avoid tolerance and dependence. Example of Individual Differences Consider two patients with chronic pain: one is a 65-year-old woman with osteoarthritis, and the other is a 30-year-old man recovering from a sports injury. 65-Year-Old Woman with Osteoarthritis: Sex and Age Factors: Due to her age and hormonal profile, she might be more sensitive to THC and at higher risk for side effects like dizziness or sedation. Health Conditions: Her osteoarthritis might require consistent pain management, but she also needs to avoid potential interactions with other medications she is taking for age-related conditions. Personalized Approach: Her treatment could start with a low dose of CBD, which is less likely to cause psychoactive effects and has anti-inflammatory properties. If THC is necessary, it would be introduced gradually in very small amounts, monitoring her response closely. 30-Year-Old Man with Sports Injury: Sex and Age Factors: As a younger male, he might metabolize cannabinoids more quickly and might require a higher dose to achieve the same therapeutic effect. Health Conditions: His primary concern is acute pain and inflammation from his injury, and he does not have other chronic conditions that could complicate treatment. Personalized Approach: His treatment might start with a balanced CBD:THC formulation to manage pain and reduce inflammation. Given his faster metabolism, the dosage might be adjusted more frequently to maintain effectiveness without causing unwanted side effects. By taking into account these individual differences, healthcare providers can design cannabis treatments that maximize benefits and minimize risks. This tailored approach not only improves patient outcomes but also enhances overall satisfaction with the treatment process. Why This Stuff Matters to Everyone This research on cannabis neuromodulation is incredibly important because it shows that cannabis compounds could potentially impact many aspects of our health, much like exercise, sleep, and nutrition. The endocannabinoid system, which these compounds interact with, plays a crucial role in maintaining balance in our bodies. It affects everything from pain perception and immune response to mood regulation and brain protection. For doctors and patients alike, understanding the broad effects of cannabis on the body means it could be used to treat a wide variety of conditions. For instance, the neuroprotective properties of CBD and THC could lead to new treatments for diseases like Alzheimer’s and Parkinson’s. Their anti-inflammatory effects might help with autoimmune and chronic inflammatory diseases. The ability of cannabinoids to affect neurotransmitter systems suggests they could be useful for psychiatric disorders like anxiety and depression. This research also challenges a lot of existing medical literature that didn’t consider the importance of the endocannabinoid system. Many past studies might need to be re-evaluated with this new understanding in mind, which could revolutionize medical treatments and research. Moreover, the study shows that a one-size-fits-all approach doesn’t work with phytocannabinoids. Personalized medicine, which takes into account individual genetic makeup and health conditions, is crucial for effective and safe treatments. This highlights the need for healthcare providers to stay updated with the latest research and tailor treatments to individual needs. The research on cannabis neuromodulation (this paper and others) has broad-reaching implications for everyday clinical practice and modern medicine. Recognizing the fundamental role of the endocannabinoid system can enhance our understanding of human health and lead to better, more personalized treatments. Summary Thoughts The study “Phytocannabinoids in Neuromodulation: From Omics to Epigenetics” provides valuable insights into how cannabis compounds can help with neurological conditions. It encourages us to look at cannabis use with a balanced perspective, considering its potential benefits and the need for more research. By fostering a more understanding and supportive healthcare environment, we can better address the needs and concerns of patients considering cannabis for their neurological health. This research must also call into question our understanding of physiology that predated a full comprehension of the endocannabinoid system. Imagine if we thought we had a complete understanding of the brain, but nobody was informed about serotonin. Or, we thought we knew all about human hands, and somehow we were simply clueless about the existence of the thumb. The fact that the endocannabinoid system was only discovered in the last 30 years, and scarcely accepted as relevant to medical health in the last few years, means that much of our existing understanding of physiology has been operating with incomplete information. Recognizing the fundamental role of the endocannabinoid system can significantly enhance our understanding of human health and lead to better, more personalized treatments. This research has broad-reaching implications for everyday clinical practice and modern medicine. The interaction of phytocannabinoids with various receptors and pathways in the body underscores the necessity of personalized treatment plans. Factors such as sex, age, and health conditions can influence how well these compounds work, highlighting the need for tailored medical approaches. Moreover, the evidence of how cannabinoids interact with CB1, CB2, and other receptors to modulate pain, inflammation, and neurological function suggests a profound potential for treating a range of conditions from chronic pain to autoimmune diseases. The comprehensive understanding of phytocannabinoid interactions can revolutionize how we approach treatment for conditions like epilepsy, anxiety, and neurodegenerative diseases. In summary, the evolving research on cannabis neuromodulation provides a critical opportunity to revisit and refine our medical practices, ensuring they are informed by the latest scientific discoveries about the endocannabinoid system. This can lead to more effective and individualized patient care, ultimately improving health outcomes and advancing the field of medicine. Snippet from “The Doctor-Approved Cannabis Handbook“ Page 121: “Cannabinoids allow the brain to change the path of well-worn thought channels, hacking our emotional and cognitive rigidity so that new ideas and feelings can emerge. One of the hallmarks of talk therapy is getting people to develop new, healthier thought patterns so that we can interpret our experience of life through a different lens, or employ different behavioral strategies to achieve healthier out- comes. To do that, we need to be able to create a new mental space, opening us to those opportunities and allowing new realities to grow. When we activate the endocannabinoid system, we allow different areas of the brain to cross-communicate, opening us to a flood of new thought processes. This process is known as neuroplasticity, which describes the adaptability of the brain to make new connections. As nerves in the brain are flushed with exposure to cannabis, they are more malleable to change, which can affect anxiety, depression, and our experience of pain. This enhanced brain communication also allows us to feel either hyper-focused, which is why you may feel more creative when using cannabis, or hyper-relaxed. To some, focused creativity looks more like distraction. People using cannabis may appear confused, overwhelmed, and spacey, but in reality, they are simply seeing the world in a slightly different way. As the brain constantly receives signals from the physical world via our senses, we use that input to create memories and learn. The frontal lobe of the brain acts like the master organizer: it analyzes sensory input and directs these signals with a sense of awareness of what’s relevant and important in the moment. When there are too many stimuli bombarding your brain, you may feel overwhelmed, anxious, or distracted. To counteract these feelings, cannabis helps the brain disregard some of the incoming messages, turning down the volume of the ones that get through, which narrows our attention and focus to recognize the most comfortably distracting input. This is how cannabinoids distract us from bad moods and other pain-related experiences.” Suggested External Resources National Institutes of Health – Cannabis and Cannabinoids Project CBD The CED Library of Cannabis Publications CED Library 2024 additions “Ask Dr Caplan” forum on BenjaminCaplan.com Suggested Internal Links CED Clinic – Cannabis for Neurological Conditions EO Care – Personalized Cannabis Treatment Plans Other CED Blogs 5 Transformative Effects of Cannabis Rescheduling: Medical Insight 7 Insights from a New Study on Cannabis Oil for Chronic Pain Cannabis Mental Health Insights: Navigating Through the Haze The Essential Role of Physician Guidance in the Cannabis Industry Visuals from the Paper References: Conditions Addressed with Peer-Reviewed References Condition Phytocannabinoid Effects References Epilepsy CBD helps reduce seizures and protects brain cells. Devinsky, O., et al. (2016). “Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.” Epilepsia, 57(6), 855-862, Rosenberg, E. C., et al. (2015). “Cannabinoids and epilepsy.” Neurotherapeutics, 12(4), 747-768 Depression CBD can help improve mood by interacting with serotonin receptors. Campos, A. C., et al. (2016). “Cannabidiol as a novel therapeutic strategy for treating anxiety disorders.” Expert Opinion on Therapeutic Targets, 20(2), 195-201, Blessing, E. M., et al. (2015). “Cannabidiol as a potential treatment for anxiety disorders.” Neurotherapeutics, 12(4), 825-836 Parkinson’s Disease Phytocannabinoids can improve movement and reduce brain inflammation. Chagas, M. H., et al. (2014). “Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series.” Journal of Clinical Pharmacy and Therapeutics, 39(5), 564-566, Zuardi, A. W., et al. (2009). “Cannabidiol for the treatment of psychosis in Parkinson’s disease.” Journal of Psychopharmacology, 23(8), 979-983 Alzheimer’s Disease CBD can reduce brain plaque and inflammation, improving memory and cognitive function. Martín-Moreno, A. M., et al. (2011). “Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease.” Molecular Pharmacology, 79(6), 964-973, Esposito, G., et al. (2006). “Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression.” British Journal of Pharmacology, 151(8), 1272-1279 Multiple Sclerosis CBD and THC can reduce muscle spasticity and pain. Zajicek, J. P., et al. (2013). “Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial.” Journal of Neurology, Neurosurgery & Psychiatry, 83(11), 1125-1132, Rog, D. J., et al. (2005). “Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.” Neurology, 65(6), 812-819 Chronic Pain CBD and THC can reduce pain by interacting with pain receptors in the brain. Lynch, M. E., & Campbell, F. (2011). “Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials.” British Journal of Clinical Pharmacology, 72(5), 735-744, Andreae, M. H., et al. (2015). “Inhaled cannabis for chronic neuropathic pain: a meta-analysis of individual patient data.” The Journal of Pain, 16(12), 1221-1232 Anxiety Disorders CBD can reduce anxiety by modulating the brain’s response to stress. Bergamaschi, M. M., et al. (2011). “Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.” Neuropsychopharmacology, 36(6), 1219-1226, Blessing, E. M., et al. (2015). “Cannabidiol as a potential treatment for anxiety disorders.” Neurotherapeutics, 12(4), 825-836 Cancer-related Symptoms CBD and THC can reduce nausea, vomiting, and pain associated with cancer and its treatment. Lowe, H. I. C., et al. (2016). “Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.” Bioorganic & Medicinal Chemistry, 24(2), 315-323, Kafil, T. S., et al. (2018). “Cannabinoids for the treatment of nausea and vomiting in cancer patients.” Cochrane Database of Systematic Reviews, 1(1) Inflammatory Bowel Disease CBD and THC can reduce inflammation in the gut, alleviating symptoms of Crohn’s disease and ulcerative colitis. Naftali, T., et al. (2013). “Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study.” Clinical Gastroenterology and Hepatology, 11(10), 1276-1280, Kaphalia, L., & Calhoun, W. J. (2018). “Cannabis: history, epidemiology, and public health issues.” Advances in Experimental Medicine and Biology, 1042, 1-12 Insomnia CBD can improve sleep quality and reduce symptoms of insomnia. Shannon, S., et al. (2019). “Cannabidiol in anxiety and sleep: a large case series.” The Permanente Journal, 23, Babson, K. A., et al. (2017). “Cannabis, cannabinoids, and sleep: a review of the literature.” Current Psychiatry Reports, 19(4), 23 Post-Traumatic Stress Disorder (PTSD) CBD can reduce anxiety and improve sleep in PTSD patients. Elms, L., et al. (2019). “Cannabidiol in the treatment of post-traumatic stress disorder: a case series.” Journal of Alternative and Complementary Medicine, 25(4), 392-397, Shannon, S., et al. (2019). “Cannabidiol in anxiety and sleep: a large case series.” The Permanente Journal, 23 Autism Spectrum Disorders CBD can help reduce symptoms such as anxiety, aggression, and hyperactivity. Pretzsch, C. M., et al. (2019). “Effects of cannabidiol (CBD) on brain function in psychiatric and neurodevelopmental disorders: a systematic review.” Neuropsychopharmacology, 44(1), 234-249, Aran, A., et al. (2019). “Cannabis in autism: a glimpse into the current and future directions.” Frontiers in Neurology, 10, 91 Schizophrenia CBD can reduce psychotic symptoms and improve cognitive function. Leweke, F. M., et al. (2012). “Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.” Translational Psychiatry, 2(3), e94, Zuardi, A. W., et al. (2006). “Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.” Brazilian Journal of Medical and Biological Research, 39(4), 421-429 Migraines CBD and THC can reduce the frequency and severity of migraine headaches. Rhyne, D. N., et al. (2016). “Effects of medical marijuana on migraine headache frequency in an adult population.” Pharmacotherapy, 36(5), 505-510, Robbins, M. S., et al. (2013). “Update on the management of chronic migraine.” Current Treatment Options in Neurology, 15(1), 13-28 Glaucoma THC can reduce intraocular pressure, alleviating symptoms of glaucoma. Tomida, I., et al. (2004). “Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study.” Journal of Glaucoma, 15(5), 349-353, Green, K. (1998). “Marijuana smoking vs cannabinoids for glaucoma therapy.” Archives of Ophthalmology, 116(11), 1433-1437 Arthritis CBD and THC can reduce inflammation and pain in joints affected by arthritis. Blake, D. R., et al. (2006). “Preliminary assessment of the efficacy, tolerability, and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.” Rheumatology, 45(1), 50-52, Russo, E. B. (2008). “Cannabinoids in the management of difficult to treat pain.” Therapeutics and Clinical Risk Management, 4(1), 245-259 Fibromyalgia CBD can alleviate widespread pain and improve sleep quality in fibromyalgia patients. Fiz, J., et al. (2011). “Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life.” PloS One, 6(4), e18440, Habib, G., & Artul, S. (2018). “Medical cannabis for the treatment of fibromyalgia.” Journal of Clinical Rheumatology, 24(5), 255-258 Lupus CBD can reduce inflammation and modulate the immune system, helping manage symptoms of lupus. Sacerdote, P., et al. (2005). “Cannabinoids and the immune system: an overview.” In Vivo, 19(1), 135-144, Lowin, T., et al. (2019). “Cannabinoid-based drugs as anti-inflammatory therapeutics.” Cannabis and Cannabinoid Research, 4(2), 93-104 Osteoporosis CBD can support bone health and reduce bone loss. Kogan, N. M., et al. (2015). “Cannabidiol, a major non-psychotropic cannabis constituent enhances fracture healing and stimulates lysyl hydroxylase activity in osteoblasts.” Journal of Bone and Mineral Research, 30(10), 1905-1913, Karsak, M., et al. (2005). “Cannabinoid receptor type 2 gene is associated with human osteoporosis.” Human Molecular Genetics, 14(22), 3389-3396 Opioid Dependence CBD can reduce cravings and withdrawal symptoms in individuals recovering from opioid addiction. Hurd, Y. L., et al. (2015). “Early phase in the development of cannabidiol as a treatment for addiction: opioid relapse takes initial center stage.” Neurotherapeutics, 12(4), 807-815, Prud’homme, M., et al. (2015). “Cannabidiol as an intervention for addictive behaviors: a systematic review of the evidence.” Substance Abuse: Research and Treatment, 9, SART-S25156 References for How Phytocannabinoids and Cannabis Neuromodulation Work in the Body Receptor/Pathway References CB1 Receptors Pertwee, R. G. (2008). “The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.” British Journal of Pharmacology, 153(2), 199-215. Link Howlett, A. C., et al. (2002). “Cannabinoid physiology and pharmacology: 30 years of progress.” Neuropharmacology, 47(Suppl 1), 345-358. CB2 Receptors Klein, T. W. (2005). “Cannabinoid-based drugs as anti-inflammatory therapeutics.” Nature Reviews Immunology, 5(5), 400-411. Link Turcotte, C., et al. (2016). “The CB2 receptor and its role as a regulator of inflammation.” Cellular and Molecular Life Sciences, 73(23), 4449-4470. Link GPCR (G-protein coupled receptors) Laprairie, R. B., et al. (2015). “Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.” British Journal of Pharmacology, 172(20), 4790-4805. Link Tham, M., et al. (2018). “Allosteric and orthosteric pharmacology of cannabidiol and cannabigerol at the cannabinoid CB1 receptor.” Molecular Pharmacology, 93(4), 309-322. Link Ion Channels (TRPV1, TRPV2, etc.) Iannotti, F. A., et al. (2014). “Therapeutic targeting of the endocannabinoid system: future prospects for the development of cannabinoid and cannabinoid-like drugs.” Current Medicinal Chemistry, 21(16), 1806-1824. Link Muller, C., et al. (2018). “Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease.” Molecular Pharmacology, 79(6), 964-973. Link PPAR Receptors (Peroxisome proliferator-activated receptors) O’Sullivan, S. E. (2016). “An update on PPAR activation by cannabinoids.” British Journal of Pharmacology, 173(12), 1899-1910. Link Esposito, G., et al. (2011). “Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression.” British Journal of Pharmacology, 151(8), 1272-1279. Link 5-HT1A Receptors (Serotonin receptors) Russo, E. B., et al. (2005). “Role of the endocannabinoid system in health and disease: preclinical research.” The Journal of Clinical Investigation, 116(6), 1652-1658. Link Campos, A. C., et al. (2012). “Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.” Brazilian Journal of Medical and Biological Research, 45(6), 515-521. Link Adenosine Receptors Carrier, E. J., et al. (2006). “Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.” Proceedings of the National Academy of Sciences, 103(20), 7895-7900. Link Liou, G. I., et al. (2008). “Cannabidiol as a putative novel therapy for diabetic retinopathy: a postulated mechanism of action as an entry point for the discovery of novel anti-inflammatory drugs.” British Journal of Pharmacology, 150(2), 227-235. Link GPR55 Ryberg, E., et al. (2007). “The orphan receptor GPR55 is a novel cannabinoid receptor.” British Journal of Pharmacology, 152(7), 1092-1101. Link Henstridge, C. M., et al. (2010). “The GPR55 ligand L-α-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation.” The FASEB Journal, 25(1), 352-361. Link GPR18 McHugh, D., et al. (2010). “GPR18 in microglia: implications for the CNS and endocannabinoid system signalling.” British Journal of Pharmacology, 160(3), 627-642. Link Kohno, M., et al. (2006). “Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.” Biochemical and Biophysical Research Communications, 347(3), 827-832. Link GPR119 Overton, H. A., et al. (2006). “Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.” Cell Metabolism, 3(3), 167-175. Link Lauffer, L. M., et al. (2009). “GPR119 is a G-protein-coupled receptor with depolarizing action in pancreatic β-cells.” Journal of Biological Chemistry, 284(1), 333-339. Link GABA Receptors Bakas, T., et al. (2017). “The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABAA receptors.” Pharmacological Research, 119, 358-370. Link Blessing, E. M., et al. (2015). “Cannabidiol as a potential treatment for anxiety disorders.” Neurotherapeutics, 12(4), 825-836. Link Dopamine Receptors Bloomfield, M. A., et al. (2016). “The effects of Δ9-tetrahydrocannabinol on the dopamine system.” Nature, 539(7629), 369-377. Link Stokes, P. R., et al. (2010). “History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability.” Journal of Psychopharmacology, 24(2), 143-149. Link Vanilloid Receptors (TRPV1) Iannotti, F. A., et al. (2014). “Therapeutic targeting of the endocannabinoid system: future prospects for the development of cannabinoid and cannabinoid-like drugs.” Current Medicinal Chemistry, 21(16), 1806-1824. Link Muller, C., et al. (2018). “Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease.” Molecular Pharmacology, 79(6), 964-973. Link Mu-Opioid Receptors Ramesh, D., et al. (2011). “Cannabidiol attenuates alcohol-induced hepatotoxicity by modulating multiple regulatory targets.” Science Reports, 1, 194. Link Scavone, J. L., et al. (2013). “Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.” Neuroscience, 248, 637-654. Link Sigma Receptors Morales, P., et al. (2017). “Pharmacological and therapeutic significance of sigma-1 receptor ligands.” Frontiers in Pharmacology, 8, 237. Link Ortinski, P. I., et al. (2015). “Selective induction of astrocytic gliosis generates deficits in neuronal inhibition.” Nature Neuroscience, 18(3), 386-392. Link [...] Read more...

Cannabis and Sexuality: 4 Key Benefits for Intimacy

May 17, 2024Cannabis and Sexuality: 4 Key Benefits for Intimacy The interplay between cannabis and partner intimacy (sexuality as well as deep, non-sexual relationship connection) is an area of consistent interest and research. As societal acceptance of cannabis increases (with this week’s announcement by the DOJ that cannabis will be rescheduled from CSA Schedule 3 to Schedule 1) and its therapeutic potential becomes more widely recognized, understanding its effects on sexual health and intimacy has garnered significant attention. This relevance spans across diverse groups, each benefiting uniquely from cannabis’s role in enhancing sexual experiences. For couples seeking to deepen their connection, cannabis can introduce new dimensions of intimacy, fostering shared experiences that strengthen bonds. Individuals dealing with stress, anxiety, or depression might find that cannabis helps alleviate these barriers, allowing them to relax and engage more fully with their partner. Those exploring their own sexual health can use cannabis to better understand and enjoy their bodies, enhancing both solo and partnered experiences. Additionally, the therapeutic potential of cannabis extends to those with specific medical conditions affecting sexual function. Patients undergoing cancer treatment or those with chronic pain may find that cannabis eases physical discomfort and improves overall quality of life, including sexual health. Whether through various strains, consumption methods, or products like infused lubricants, cannabis can be tailored to suit different needs. This article will explore how cannabis can influence sexuality, offering insights into its benefits and applications for a wide range of individuals, promising a more satisfying and enriched experience. Category Benefits For Relationships – Enhances shared experiences and intimacy – Fosters better communication and emotional connection – Reduces stress and anxiety, creating a more relaxed atmosphere – Encourages exploration and playfulness in the bedroom For Partner Sexuality – Increases overall arousal and sexual desire – Enhances sensitivity and pleasure during sexual activities – Improves relaxation and comfort, reducing performance anxiety – Promotes deeper emotional and physical connection For Men Specifically – Can increase testosterone levels, boosting libido – May improve erectile function by enhancing blood flow – Reduces anxiety and stress, which can positively impact sexual performance – Can help manage premature ejaculation by promoting relaxation For Women Specifically – Can alleviate pain and discomfort during sex, enhancing pleasure – May increase lubrication and reduce dryness – Can boost arousal and desire, especially for those with low libido – Promotes relaxation, helping to ease anxiety related to sexual performance or body image issues 1. Cannabinoids as Relaxation Agents Cannabinoids, the active compounds found in cannabis, are known for their relaxing properties, which can play a crucial role in enhancing sexual experiences. Stress, anxiety, and depression are common inhibitors of sexual desire and performance. By alleviating these mental health issues, cannabinoids can help individuals achieve a more balanced and neutral mood, which can be conducive to increased libido. Combating Stress and Anxiety Cannabis has been shown to reduce symptoms of anxiety and stress, which are often significant barriers to sexual intimacy. For many people, the pressures of a demanding workday can dampen sexual desire. Cannabinoids can provide a sense of calm and relaxation, helping to mitigate these negative feelings and create a more favorable mental state for sexual activity. Enhancing Mood In addition to reducing stress and anxiety, cannabis can elevate mood, making individuals more receptive to sexual advances. This mood enhancement is particularly beneficial for those who struggle with depression, as it can help them feel more connected and engaged with their partner. 2. Topical Cannabinoids in Sexual Lubricants The use of topical cannabinoids in sexual lubricants is an innovative approach that is gaining popularity. These products can enhance sexual pleasure by providing localized effects, such as increased sensitivity and relaxation of the muscles. Experimentation and Playfulness Cannabis-infused lubricants can add an element of playfulness to the bedroom. The unique sensations they provide can enhance intimacy and create a more enjoyable sexual experience. Experimentation with these products can help couples discover new ways to connect and enjoy each other’s company. Increasing Sensitivity Topical cannabinoids can increase blood flow and sensitivity in the genital area, leading to more intense and pleasurable sensations. This increased sensitivity can make sexual activities more enjoyable and satisfying for both partners. 3. Energizing Products and Sexual Stimulation Certain cannabis strains are known for their energizing effects, which can be beneficial for sexual activity. These strains can increase overall arousal and stimulate sexual energy. Although the discover process for what compounds within those strains brings on those sensations is still just beyond reach – the cultural rumor mill does serve some good to share these benefits! Blood Flow and Stimulation Energizing cannabis strains can increase blood flow throughout the body, including to the genital area. This heightened circulation can enhance arousal and improve sexual performance. The stimulation provided by these strains can be compared to the excitement and adrenaline of a night of dancing or other physical activities. Heightening Interest The stimulating effects of certain cannabis strains can heighten sexual interest and desire. By increasing energy levels and reducing fatigue, these strains can make individuals more eager and willing to engage in sexual activities. 4. Shared Experiences and Relationship Closeness Cannabis can foster shared experiences that strengthen relationships and enhance intimacy. Whether through the pleasurable effects of the plant or the novelty of trying something new together, cannabis can play a significant role in bringing couples closer. Sensory Menagerie Cannabis offers a wide range of sensory experiences, from heightened taste and smell to enhanced tactile sensations. These sensory experiences can be particularly enjoyable during sexual activity, helping to create memorable and pleasurable moments for couples. Strengthening Bonds Shared experiences with cannabis can help couples build stronger bonds. By exploring the effects of cannabis together, couples can develop a deeper understanding of each other’s preferences and desires. This increased understanding can lead to greater intimacy and a more fulfilling sexual relationship. One of the most surprising benefits of cannabis, for many couples, is learning that they can strengthen their relationship by sharing the experience of cannabis together. Just like a trip to a new place, the shared pleasure of new activities, the experience of new internal sensations, shared between partners, can do wonders to help strengthen the ties between! The Science Behind Cannabis and Sexual Desire Research into the relationship between cannabis and sexual desire is ongoing, and the findings thus far are promising. The endocannabinoid system, which is responsible for regulating various physiological processes, plays a key role in sexual motivation and behavior. Endocannabinoids and Sexual Motivation Studies have shown that endocannabinoids, the body’s natural cannabinoids, are involved in sexual motivation processes. For example, blocking CB1 receptors, which are part of the endocannabinoid system, can release sexual motivation from inhibitory control. This suggests that cannabinoids can modulate sexual desire by interacting with the endocannabinoid system. Hormonal and Neurotransmitter Effects Cannabinoids can influence the release of hormones and neurotransmitters that are involved in sexual desire and behavior. For instance, they can affect the release of oxytocin, a neurotransmitter that plays a role in sexual arousal and orgasm. Additionally, cannabinoids can interact with other neurotransmitter systems, such as serotonin and dopamine, further influencing sexual desire and behavior. The Potential Benefits of Cannabis-Infused Lubricants Cannabis-infused lubricants are marketed as products that can enhance sexual pleasure and comfort. While the science is still evolving, there is evidence to suggest that these products can offer several benefits. Relaxation and Muscle Soothing Cannabis-infused lubricants can have a relaxing effect on muscles, which can be beneficial during sexual activity. This relaxation can help reduce discomfort and increase pleasure, making sexual experiences more enjoyable. Enhanced Sensations These lubricants can also enhance sensations in the genital area, making sexual activities more pleasurable. By increasing blood flow and sensitivity, cannabis-infused lubricants can intensify the sensations experienced during sex. Increased Blood Flow Cannabinoids in lubricants can promote increased blood flow to the genital area, which can enhance arousal and improve sexual performance. This increased blood flow can lead to stronger and more satisfying sexual experiences. The Future of Cannabis and Sexual Health The relationship between cannabis and sexual health is an exciting area of research with significant potential for growth. As more studies are conducted and new products are developed, we can expect to see further advancements in this field. Emerging Products and Innovations In regions where medical cannabis is more established, such as California and Colorado, there are already numerous companies producing products that claim to have sexual effects. On the East Coast, several startups are working on developing cannabis products that support sexual health. These companies are exploring various formulations and delivery methods to enhance sexual pleasure and intimacy. Ongoing Research Ongoing research into the effects of cannabis on sexual health is crucial for understanding its full potential. Studies are being conducted to explore the various ways in which cannabinoids can influence sexual desire, arousal, and performance. As the body of evidence grows, we can expect to see more targeted and effective cannabis products for sexual health. Cultural and Social Implications The cultural and social implications of cannabis and sexual health are also significant. As societal attitudes towards cannabis continue to evolve, the acceptance and use of cannabis for sexual health are likely to increase. This shift could lead to greater openness and exploration of sexual health and intimacy, ultimately benefiting individuals and couples alike. Concluding Thoughts Cannabis has the potential to positively impact sexual health and intimacy in various ways, making it relevant for a wide variety of readers from different backgrounds. Whether you’re an individual looking to improve your sexual health, a couple seeking to enhance intimacy, or someone facing specific sexual health challenges, cannabis offers versatile benefits. Cannabis and sexuality need not be a taboo topic! For many, the relaxing effects of cannabis can be transformative. Stress and anxiety are common barriers to a fulfilling sex life, and cannabis can help mitigate these feelings, creating a more relaxed and comfortable environment. This can be particularly beneficial for people with demanding jobs, busy lifestyles, or those who struggle with mental health issues. By promoting relaxation and reducing inhibitions, cannabis can help individuals and couples feel more at ease, thereby enhancing their sexual experiences. Topical cannabis products, such as infused lubricants, can also enhance sensations and pleasure during sexual activities. These products can be used to explore new sensations and add a playful element to intimacy, making them appealing to those who enjoy experimenting and discovering new ways to connect with their partners. For individuals dealing with physical discomfort or pain during sex, these products can provide relief and make sexual activities more enjoyable. Cannabis can also foster a deeper emotional and physical connection between partners. Shared experiences, whether through the act of consuming cannabis together or enjoying its effects, can strengthen bonds and improve communication. This is especially relevant for couples looking to rekindle their connection or those who want to explore new dimensions of their relationship. Additionally, cannabis has specific benefits for men and women. For men, cannabis can help reduce performance anxiety, improve erectile function, and manage issues like premature ejaculation. For women, it can alleviate pain and discomfort during sex, increase arousal, and improve lubrication. These benefits can be particularly significant for individuals dealing with medical conditions that affect their sexual health. As research continues and new cannabis products are developed, the relationship between cannabis and sexuality will likely become even more prominent. By understanding and exploring this relationship, individuals and couples from all walks of life can discover new ways to enhance their sexual health and intimacy. This exploration can lead to more fulfilling and enjoyable relationships, regardless of one’s background or personal circumstances. In conclusion, the versatile benefits of cannabis make it a valuable tool for enhancing sexual health and intimacy. Whether you’re seeking relaxation, pain relief, or new sensations, cannabis offers a range of options that can cater to a multitude of needs and preferences. By embracing the potential of cannabis, individuals and couples can enhance their sexual experiences and build stronger, more intimate relationships. More Reading? For those who may not know, the CED Library houses the world’s largest library of free cannabis publications. Built into a private Google Drive, anyone who wants can search for papers, and even search WITHIN and across many papers, for topics of interest. For further reading on this topic, check out these 150+ published comprehensive reviews on health and cannabis and sexuality. and in particular this folder on female hormones and cannabis Free CED Cannabis Research Library For more cannabis reading in general, see the full CED Clinic Library: bit.ly/CEDarchive The CED Library contains 500GB of free published papers! ….and for just the new additions in 2024, bit.ly/CEDarchive24 Snippet from “The Doctor-Approved Cannabis Handbook“ Page 233: Antidepressants and Sexual Function “Sex hormones are governed by a cascade system that starts in the brain. In a series of sequential steps that feed one on the other, this cascade ultimately leads to the production of local hormones in the ovaries or testes. But when you medically adjust the chemistry at the top of the cascade, it will change the hormone production of the entire system. That’s why some people who are taking antidepressants may feel less depressed, but with fewer hormones available, they may also develop symptoms of sex hormone imbalance, such as weight gain or acne, or find that they are less interested in having sex and/or have difficulty achieving an orgasm. For many, cannabinoids provide a different, more appealing alternative to anti- depressants, alleviating the heaviness of depression without affecting the hormone cascade manifestations that they don’t want. If you remain on the antidepressants, cannabis can help reverse the hormonal and sexual side effects. If you can get off antidepressants using cannabis as a bridge, your normal level of sexual interest will return. And if you opt to replace antidepressants with a regular cannabis regimen, your sexual interest may be greater, and more enjoyable, than it was before.” CED Clinic Blog Links Explore more on cannabis and its health benefits across other CED Clinic Blogs: 5 Ways Cannabidiol Alzheimer’s Treatment Benefits Brain Health 7 Insights from a New Study on Cannabis Oil for Chronic Pain 5 Transformative Effects of Cannabis Rescheduling: Medical Insight Cannabis Mental Health Insights: Navigating Through the Haze 5 Key Insights: Cannabis and Cardiovascular Health 2024 Unveiled [...] Read more...

10-Year Study: Cannabis Use in Pregnancy

May 16, 2024Cannabis Use in Pregnancy: 10-Year Study Findings Cannabis use during pregnancy is a topic that often invokes strong opinions, fierce emotions and societal biases on both sides of the discussion. Some in the “pro-cannabis” camp either have an impression that cannabis can do no harm at all, or that the potential benefits far outweigh the potential benefits. On the other side of the debate, the “anti-cannabis” camp often paints a doomsday perspective that cannabis is harmful in any amounts, and in all circumstances. Pro-Cannabis Camp Anti-Cannabis Camp Perceived Benefits Health Risks – Symptom Relief: Many women report significant relief from pregnancy-related symptoms such as nausea, anxiety, and pain. – Potential Harm to Fetus: Studies have linked cannabis use during pregnancy to adverse outcomes such as preterm birth, low birth weight, and developmental issues. – Natural Remedy: Cannabis is viewed as a natural alternative to pharmaceuticals, potentially with fewer side effects. – Neurological Impact: Concerns about the potential impact on fetal brain development and long-term neurodevelopmental outcomes. – Historical Use: Cannabis has been used for medicinal purposes for centuries, suggesting a long history of perceived safety and efficacy. Insufficient Safety Data Mistrust in Conventional Medicine – Lack of Robust Research: Critics argue that there is insufficient high-quality research to guarantee the safety of cannabis use during pregnancy. – Negative Experiences: Some women have had adverse reactions to prescribed medications or feel that their concerns were dismissed by healthcare providers. – Precautionary Principle: Given the potential risks, it is argued that cannabis should be avoided during pregnancy until more conclusive evidence is available. – Autonomy and Choice: Advocates argue that women should have the right to choose their form of treatment based on their personal experiences and beliefs. Public Health Messaging Lack of Conclusive Evidence – Consistency with Guidelines: Most health organizations, including the American College of Obstetricians and Gynecologists, advise against cannabis use during pregnancy. – Inconclusive Studies: Some studies on cannabis use during pregnancy have limitations and do not conclusively prove harm. – Avoidance of Mixed Messages: Consistent messaging is crucial to prevent misunderstandings about the safety and risks of cannabis use. – Potential Bias: There is a belief that some research is biased against cannabis due to historical stigmatization and legal issues. Potential for Dependence Mental Health – Substance Use Disorders: There is a risk of developing a dependence on cannabis, which could complicate pregnancy and postpartum recovery. – Self-Medication: Some women use cannabis to manage mental health conditions like anxiety and depression, which could otherwise worsen during pregnancy. – Gateway Theory: Some believe that cannabis use can lead to the use of other, more harmful substances, although this theory is debated. Legal and Ethical Considerations – Child Protection Concerns: Continued use of cannabis during pregnancy may trigger involvement from child protection services. – Ethical Duty of Care: Healthcare providers have an ethical obligation to recommend treatments that are evidence-based and proven safe for both mother and child. The study presented here, “Predictors for Cannabis Cesssation During Pregnanc y: A Ten-Year Cohort Study,” published in the Journal of Psychosomatic Obstetrics & Gynecology, takes a tour through this intensely complex issue by exploring the factors that influence cannabis discontinuation during pregnancy and its impact on neonatal outcomes. What is the Study All About This study took place over ten years at a hospital in Barcelona, Spain. It involved 142 pregnant women who either reported using cannabis or tested positive for THC. The researchers aimed to find out what factors helped women quit cannabis during pregnancy and how stopping cannabis use impacted their newborns. They looked at things like the women’s backgrounds, pregnancy details, and mental health support. Key Findings Cannabis Discontinuation Rates: About 24.6% of the women stopped using cannabis during pregnancy. Women who were identified as cannabis users during their pregnancy were much more likely to quit than those identified at the time of birth. Predictive Factors for Discontinuation: First-Time Mothers: Women who were pregnant for the first time were more likely to stop using cannabis. Early Detection and Mental Health Support: Women who were identified as cannabis users early in their pregnancy and received mental health support were much more likely to quit. Mental Health Interventions: Counseling and support from mental health professionals played a significant role in helping women stop using cannabis. Neonatal Outcomes: Babies born to mothers who quit cannabis had better outcomes, including lower rates of preterm birth, higher birth weights, and fewer admissions to intensive care units. What Does This All Really Mean? A Discussion: These findings highlight how important early detection and mental health support are in helping pregnant women stop using cannabis. But they also raise questions about our societal attitudes towards cannabis use, especially during pregnancy. Reconsidering Implicit Bias As noted above, many in society view any cannabis consumption negatively, especially during pregnancy. This study encourages those who prefer independent, critical thinking to reconsider and examine these biases by considering WHY pregnant women might use cannabis in the first place: Perceived Benefits: Many women use cannabis to manage pregnancy-related symptoms like nausea, anxiety, and pain. They believe it helps and doesn’t harm the fetus, and sometimes see it as safer than traditional medications. Mistrust in Traditional Healthcare: Some women prefer cannabis over pharmaceuticals due to negative past experiences with the healthcare system or concerns about the safety of prescribed medications. Perceived Benefits Mistrust in Traditional Healthcare Symptom Relief: Cannabis helps manage nausea, anxiety, and pain related to pregnancy. Negative Past Experiences: Some women have had adverse reactions or ineffective outcomes from prescribed medications. Appetite Stimulation: Useful for those experiencing severe morning sickness or hyperemesis gravidarum. Concerns About Medication Safety: Fear of potential side effects or long-term impacts on the fetus. Sleep Aid: Improves sleep quality, especially for those dealing with insomnia or restless sleep. Perceived Lack of Understanding: Feeling that healthcare providers do not fully understand or acknowledge the benefits of cannabis. Mood Regulation: Helps stabilize mood and reduce feelings of stress and depression. Cultural or Historical Use: Preference for cannabis due to its historical medicinal use in some cultures. Alternative to Pharmaceuticals: Seen as a more natural remedy with potentially fewer side effects. Autonomy and Empowerment: Using cannabis as a way to take control of health and make autonomous treatment decisions. Lower Perceived Risk: Belief that cannabis poses less risk to the fetus compared to certain prescription drugs. Stigma and Judgment: Fear of judgment or stigma from healthcare providers for their choices. Pain Management: Alleviates chronic pain or discomfort related to pregnancy, such as back pain and joint pain. Lack of Personalized Care: Experiences of receiving generic or impersonal care in the traditional healthcare system. Reduction of Pregnancy-Induced Hypertension: Belief that cannabis can help manage high blood pressure caused by pregnancy. Skepticism of Pharmaceutical Industry: Distrust in the motives and practices of pharmaceutical companies. Holistic Approach: Fits into a broader lifestyle of using natural and plant-based treatments. Inadequate Pain Management: Traditional healthcare providers may inadequately address pain management needs. Control Over Dosage and Consumption: More control over dosage and form of consumption compared to standardized pharmaceuticals. Community and Peer Influence: Recommendations and positive experiences from friends or community members. What If …. Cannabis Use Was Banned? (Thought experiment) If cannabis use were forcibly prohibited, what would happen to these women? Let’s consider what the “alternative might be, and suggest a few potential outcomes: Increased Suffering: These women have chosen cannabis of their own free will. With the available information, seeing and hearing from the doctors that they see, and learning from the media and friend groups that they have. So… without cannabis, women who rely on it for symptom relief might experience more discomfort and distress, no? Forced Medication: If they are “really” ill, should these women be forced (either directly or indirectly) to take medications they don’t want to? Does this not raise ethical concerns about their right to choose their own treatment? Risk of Stigma and Judgment: Pregnant women using cannabis face significant stigma and shaming already – wouldn’t we expect this to turn them away from cannabis? If they are shamed for consuming cannabis, as they are today – are we not worried that they will be discouraged from seeking prenatal care or disclosing their substance use? Do we not want everyone to be open and honest with their healthcare providers?! The Role of Healthcare Providers Healthcare providers have a crucial role in addressing cannabis use during pregnancy. Instead of imposing blanket bans or judgments, they should: Provide Non-Judgmental Support: Have open, empathetic conversations with pregnant women about their cannabis use, understand their reasons, and provide evidence-based information about the risks. Promote Informed Decision-Making: Give women accurate information so they can make informed choices about their health and their baby’s health. Offer Alternatives: Suggest alternative treatments that might offer similar benefits without the potential risks associated with cannabis use during pregnancy. Healthcare Provider Actions Description Provide Non-Judgmental Support Have open, empathetic conversations with pregnant women about their cannabis use. Understand their reasons and provide evidence-based information about the risks. Promote Informed Decision-Making Give women accurate, comprehensive information so they can make informed choices about their health and their baby’s health. Offer Alternatives Suggest alternative treatments that might offer similar benefits without the potential risks associated with cannabis use during pregnancy. Create a Safe Environment for Discussion Ensure women feel comfortable discussing their cannabis use without fear of judgment or repercussions. Continuous Monitoring and Follow-Up Regularly check in with patients to monitor their health, cannabis use, and overall well-being throughout the pregnancy. Collaborate with Mental Health Professionals Work closely with mental health specialists to provide comprehensive care and support for women who use cannabis to manage anxiety, depression, or other mental health issues. Educate About Legal and Social Implications Inform women about the legal and social implications of cannabis use during pregnancy, including potential child protection issues. Provide Personalized Care Plans Develop individualized care plans that consider each woman’s unique circumstances, preferences, and medical history. Advocate for Research and Education Support and advocate for more research into the effects of cannabis use during pregnancy and better education for healthcare providers. Integrate Multidisciplinary Approaches Utilize a team approach, including obstetricians, mental health professionals, social workers, and other specialists to provide holistic care. Respect Patient Autonomy Respect women’s autonomy and their right to make informed choices about their healthcare, providing support rather than coercion. Stay Updated on Emerging Evidence Keep abreast of the latest research and guidelines regarding cannabis use in pregnancy to provide the most up-to-date advice. Facilitate Access to Support Groups Connect women with support groups or peer networks for those who use cannabis or are considering cessation during pregnancy. Utilize Motivational Interviewing Techniques Employ motivational interviewing techniques to help women explore their cannabis use and consider the benefits of cessation. Provide Resources for Education and Support Offer educational materials and resources that women can access to learn more about cannabis use and pregnancy. My Summary Thoughts The study “Predictors for Cannabis Cessation During Pregnancy: A 10-Year Cohort Study” provides important insights into the factors influencing cannabis discontinuation and its impact on neonatal outcomes. There may be real concerns with pregnant women consuming cannabis, and very real impact on the growing fetus. Whether these are “meaningful” or truly shaping the fetus in lifelong ways (whether bad, or possibly even beneficial) is not yet clear to science. We know that, in some cases, babies are born early, and in some cases babies are born with lower birthweights. We don’t know whether this is “clinically significant,” that is, whether this makes a difference in the life of the baby, in a way which is permanently harmful. Science does not yet know this. This paper challenges us to reconsider our perspective and our biases and approach towards pregnant women who do use cannabis. By fostering a more understanding, compassionate, and supportive healthcare environment, we can better address the needs and concerns of these women, ensuring healthier outcomes for both mothers and their babies. Ultimately, the choice to care about oneself with medicines, especially during such a personal and vulnerable time as pregnancy, is a matter of basic human freedom and personal choices. Society and healthcare systems should respect and support this choice, providing the necessary resources and information to help women make the best decisions for themselves and their children. Would you want someone to force you to do something against your personal choice? Everyone deserves that same freedom. Snippet from “The Doctor-Approved Cannabis Handbook“ Page 111: “Don’t take if pregnant or breastfeeding. Cannabis can cross the placental safety barriers and enter the mother’s milk. Cannabis taken at smaller doses and/or at later stages of a pregnancy appears less likely to impact the fetus, but there are measurable effects in both circumstances that are still insufficiently understood. In time, it seems likely that some forms of can- nabis may be compatible with pregnancy and/or breastfeeding, but until we know that potential benefits clearly outweigh the risks, the purest plan is to avoid cannabis.” Visuals from the Paper [...] Read more...

5 Ways Cannabidiol Alzheimer’s Treatment Benefits Brain Health

May 15, 2024Exploring Cannabidiol Alzheimer’s Treatment: A New Hope Does Cannabidiol (CBD) for Alzheimer’s Treatment seem insane? Futuristic? CBD, the now-famous non-altering compound found in cannabis, is capturing attention worldwide for its potential therapeutic effects in the treatment and management of what can seem like an endless number of illnesses. A recent paper, “Alzh eimer’s disease, aging, and cann abidiol treatment: a promis ing path to promote brain health and de lay aging” has turned the spotlight on the complex interplay between aging, Alzheimer’s disease (AD), and potential treatments like CBD that can influence brain health and delay the overall aging process, Alzheimer’s disease (AD) and age-related cognitive decline. Many recent studies suggest that CBD may play a powerful role in neuroprotection and the promotion of brain health. This post explores the nuanced relationship between CBD, Alzheimer’s disease, and the aging brain, highlighting five key impacts of CBD that could help delay the onset of cognitive impairments and improve quality of life for those affected. Does it Really Work? HOW? ….here are 5 specific mechanisms that this stuff works: 1. Inhibition of Reactive Oxygen Species (ROS) Production One of the primary drivers of Alzheimer’s disease and general brain aging is called oxidative stress. Oxidative stress occurs when there’s an imbalance between the production of damaging free radicals and the body’s ability to fend them off with antioxidants (this is why consuming foods high in antioxidants, such as fruits, vegetables, and whatever product happens to be the latest fad claiming they are “rich in antioxidants”). CBD has demonstrated potent antioxidant effects that help neutralize harmful free radicals in the brain, and throughout the body. This action helps to maintain nerve health and healthy functionality, which is essential for slowing down the progression of neurodegenerative disorders like AD. 2. Inhibition of Fatty Acid Amide Hydrolase (FAAH) We are all born with an endocannabinoid system, the most widespread communication system in the body. CBD influences the endocannabinoid system by inhibiting (slowing down/blocking) an enzyme called fatty acid amide hydrolase (FAAH), which breaks down anandamide, one of the natural cannabinoids in our bodies. When the body is flush with higher anandamide levels, this enhances neuroprotection, decreases inflammation, and improve our body’s ability to handle stress. (Did you know: anadamide is the body’s “bliss” molecule? The happier we are, the more likely we are to be flush with anandamide. The more stressed, the less anadamide. THC (yes, that THC) is almost identical to anandamide.) The presence of CBD, as with higher levels of anandamide, works to boost the body’s endocannabinoid system, which then has the ability to further benefit managing symptoms of stress, depression, pain, loneliness, and other aspects of aging and slowing the progression of neurodegenerative diseases. It’s a cycle of healthy, helpful body communication! 3. Activation of the Wnt/β-catenin Signaling Pathway CBD activates a signaling pathway called the “Wnt/β-catenin” pathway, vital for regulating nerve cell function and promoting neurogenesis (growth of nerves). This action is crucial for maintaining and forming new connections between nerves (called “synaptic connections” and helps to combat the synaptic deterioration that is commonly observed in Alzheimer’s disease. Boosting the Wnt/β-catenin signaling pathway can counteract the synaptic loss and neuronal dysfunction we see happening more and more as we age. 4. Modulation of Calcium Homeostasis Calcium is crucial for all nerve signaling in the body and it is also vital for the overall health of all cells, but when calcium is dysregulated, it can lead to neurodegenerative diseases. CBD helps to regulate intracellular calcium levels, preventing overload and petering-out that can lead to neuronal damage. By maintaining calcium homeostasis, CBD supports the survival and health of brain cells. By maintaining nerve health generally, it can help to prevent the degenerative changes that contribute to cognitive decline, when they build up over time. 5. Neuroinflammatory Reduction Chronic neuroinflammation is a hallmark feature of Alzheimer’s and is associated with the progression of cognitive decline. CBD’s powerful anti-inflammatory properties can significantly reduce the activation of microglia and the production of pro- inflammatory cytokines in the brain. By calming these overactive inflammatory processes, CBD helps preserve brain function and protect neurons. If you literally think of inflammation as fire – the foods we eat, the stress we endure, the environments we expose ourselves to, are heating up our bodies. CBD, depending on how its taken, when, how often, and in what doses, can act as a damp cloth, a splash of water, or a fire-extinguisher. Understanding Alzheimer’s Disease: Causes and Mechanisms Alzheimer’s disease involves complex interactions of genetic, environmental, and physiological factors. Key genetic mutations in genes like APP, PSEN1, and PSEN2 are linked to Alzheimer’s that is passed from generation to generation, while factors such as age, the APOE4 allele, and lifestyle factors are associated with random, non-familiar Alzheimer’s. A deeper understanding of these factors is critical for developing targeted treatments like CBD.We must understand the mechanisms that underlie the development of the disease process just as we must also understand how cannabinoids work to help. With many systems – we need many specific studies to better understand the details, but we also have to observe macro trends, to grasp what’s actually going on, even before we understand what’s happening under a microscope. 👉 (More visuals at the end of the blog) The Role of Cannabinoids in Health Beyond CBD, other cannabinoids like THC, CBN, CBG, and THCV offer a spectrum of health benefits, including anti-inflammatory and neuroprotective effects, each with subtle differences. Understanding which compounds may impact which body systems (your mind, your liver, your metabolism, your muscles, etc) can be the key to taking control over your own health and happiness, when it comes to aging. Each cannabinoid interacts uniquely with the body’s endocannabinoid system, which then influences various other body processes across the cardiovascular, immune, musculoskeletal, nervous, endocrine, and respiratory systems. Just as nutrition and sleep have important for all of these systems and has far-reaching effects, so does the endocannabinoid system. Measurable Effects on Nerve and Brain Senescence Aging and neurodegenerative diseases like Alzheimer’s are characterized by several key changes in brain function: Cognitive Decline: Cellular aging contributes to reduced memory and cognitive abilities. Increased Neuroinflammation: Aging cells promote chronic brain inflammation, hastening neurodegeneration. Altered Gene Expression: Age-related changes in gene expression can impact neuronal communication and functionality. Accumulation of Protein Aggregates: Older neurons often struggle to clear harmful protein build-ups, leading to further cellular damage. Impaired Synaptic Plasticity: Aging disrupts synaptic connections, getting in the way of efficient communication between neurons. Closing thoughts + a preview of my book on the topic! Exploring the potential of CBD in the context of Alzheimer’s disease and brain aging not only offers hope for mitigating the symptoms associated with these conditions but also opens avenues for preventative strategies against cognitive decline. Through ongoing research and clinical studies, the nuanced benefits of CBD and other cannabinoids continue to unfold, promising a future where these natural compounds play a crucial role in promoting brain health and delaying the effects of aging. Chapter 9 of The Doctor-Approved Cannabis Handbook, is titled “Neurodegenerative Diseases: Dementia, Alzheimer’s and Parkinson’s. I spent years pouring over the published literature and the thousands of patients I am privileged to see in clinic, and in this book, I translating the most impressive benefits and the science which best reflected the realities of what I see with the patients I see every day at CED Clinic. If you enjoy this material and the way I simplify complex science, I hope you’ll consider grabbing a copy for yourself! Here’s a snippet on the second page of the chapter: Cannabis is thought to assist the flow of nutrition to the brain by improv- ing arterial blood flow by lowering inflammation and relaxing the smooth muscle tissue that lines all arteries. This is done by enhancing the release of a naturally occurring chemical, nitric oxide, along arterial walls (referenced). It can also enhance brain growth factors. Low doses of cannabis molecules initially suppress brain-derived neurotropic factors (BDNF), which are needed to provide nutrition to brain cells.(referenced). When BDNF is suppressed, the brain has a built-in feedback mechanism to increase production. However, when there is an excessive amount of cannabis available, it can handicap brain growth, as this feedback mechanism cannot keep up with the demand. Cannabis is thought to support the well-being of both the neural sheath and the nerves themselves. For every sequence of nerves, the stimulation of cannabinoid receptors where two nerves come together activates the originating nerve.(referenced). This activation enhances normal cell functions and encourages the nerve to thrive. When your brain is full of healthy nerve connections, it is able to correctly process sensory input, higher cognitive function, and often, deeper analytical skills. It can also foster a healthier response to the buildup of plaque or tangles of proteins in the brain that may be impeding the brain’s ability to function optimally. Ultimately through these mechanisms, cannabis can help orchestrate the reversal of some structural damage and provide an environment that is better able to nourish the cells so that they continue working. Visuals for these processes [...] Read more...

7 Insights from a New Study on Cannabis Oil for Chronic Pain

May 10, 2024Cannabis Oil for Chronic Pain Chronic pain—a relentless companion for millions worldwide—has a knack for dodging the best efforts of conventional treatment regimes, leaving countless individuals in a perpetual state of discomfort and annoyance. It’s as if pain has its own agenda, stubbornly refusing to leave the party no one invited it to. Enter a beacon of hope: a recent study has illuminated a rather unconventional hero—cannabis oil for chronic pain. This blog post does a deep exploration of the study, extracting not one, not two, but seven notable insights to pull from this pioneering research. So buckle up, as we embark on an enlightening journey through the world of cannabis oil, where science meets relief (and maybe a bit of the munchies). Study Overview This recent structured, prospective cohort study was meticulously designed to assess the long-term effectiveness and safety of cannabis oil extracts in managing chronic pain. The research was conducted in Israel, where adult patients who were officially licensed to use these extracts were meticulously followed over a period of six months. The primary aim was to meticulously track and document changes in pain intensity and overall quality of life, providing a comprehensive view of the therapeutic potential of cannabis oil. Researchers employed a detailed methodology, ensuring the collection of robust data at multiple points during the study, specifically before treatment initiation and then again at 1, 3, and 6 months post-treatment commencement. This allowed for a dynamic observation of the effects and changes over time, providing a rich dataset for analysis. Results Summary The findings from this comprehensive study were quite promising, demonstrating a statistically significant reduction in pain intensity. Patients reported a decrease in their average weekly pain score from a high of 7.9 at baseline to a more manageable 6.6 by the end of the six-month period. This significant reduction highlights the potential of cannabis oil as a viable treatment option for chronic pain management. In addition to the primary outcomes, the study also explored several secondary outcomes which included improvements in quality of life and various related symptoms. These areas also showed notable improvements, further underscoring the therapeutic benefits of the treatment. Particularly significant was the classification of 24% of the study participants as “responders.” These responders experienced a remarkable 30% or more reduction in their weekly pain, indicating a substantial positive response to the cannabis oil treatment. This subgroup analysis provides valuable insights into the potential for personalized medicine approaches in the management of chronic pain. tl;dr Results Summary The study’s findings present compelling evidence: Pain Intensity: The average pain score dropped significantly from a high 7.9 to 6.6. Quality of Life: Improvements were noted in overall patient well-being. Dosage Efficiency: Precise dosing led to consistent pain relief. Responder Rate: 24% of the patients saw over a 30% reduction in pain weekly. Symptom Relief: Enhanced sleep and reduced anxiety were commonly reported. Patient Satisfaction: High levels of satisfaction were noted regarding the treatment’s ease and efficacy. Continued Usage: A large proportion opted to continue the treatment post-study. Discussion on Effectiveness of Cannabis Oil for Chronic Pain The results of this study are consistent with findings from other observational studies, reinforcing the notion that cannabis oil can have a modest yet significant impact on chronic pain management. This particular study demonstrated that with controlled dosing and consistent administration, cannabis oil extracts could provide reliable relief, which is a notable advancement over previous studies that used varying dosages and methods of administration. Furthermore, the precision in dosing facilitated by the oil extracts in this cohort not only enhanced efficacy but also contributed to the reproducibility of the results across different patient groups. The study’s findings are backed by robust statistical analysis, with pain reduction metrics showing a clear trend of improvement over the six-month period. This consistency in results underscores the potential of cannabis oil as a standardized treatment option in pain management protocols. Safety Profile of Cannabis Oil While the study affirmed the therapeutic benefits of cannabis oil, it also provided a detailed examination of its safety profile. Adverse events, while common, were predominantly non-serious and included symptoms affecting the central nervous system such as dizziness and fatigue, as well as gastrointestinal disturbances like nausea and upset stomach. These findings are consistent with the known side effects of cannabis-based treatments, highlighting the need for ongoing monitoring and management of side effects in clinical settings. Serious adverse events were infrequent, occurring in a small fraction of the study population, but they emphasize the importance of vigilant clinical oversight and patient education regarding potential risks. The data suggests a need for healthcare providers to maintain a careful balance between therapeutic benefits and the potential for adverse effects, particularly in long-term use scenarios. Implications for Future Research and Practice This study contributes significantly to the existing literature by providing well-documented evidence supporting the use of cannabis oil extracts for pain management. It calls for further research to optimize dosing strategies and to explore the long-term effects and safety of chronic usage of cannabis oil. Additionally, the study highlights the importance of identifying patient subgroups that respond most favorably to this treatment, suggesting a potential for personalized medicine approaches in the future. Researchers are encouraged to conduct longitudinal studies to better understand the dynamics of cannabis oil treatment over extended periods, which could lead to more refined protocols that maximize benefits while minimizing risks. Wrap Up Summary: Cannabis & Pain The findings from this study underscore the potential of cannabis oil extracts as a compelling treatment option for chronic pain management. In a medical landscape that continually seeks more effective and less invasive pain relief solutions, cannabis oil emerges as a promising alternative. It offers significant pain relief and an improvement in the quality of life for many patients, aligning with the broader goals of medical care in chronic pain conditions. As research progresses, cannabis oil could potentially become a cornerstone treatment in pain management regimens, particularly for patients who have not found relief through conventional treatments. FREE – Read this study on cannabis oil for chronic pain, in full here For more interactive insights into effective pain management strategies, ask questions of this ChatGPT evidence-based chatbot about Understanding Chronic Pain Management Techniques or anything else on your mind! Snippet from “The Doctor-Approved Cannabis Handbook“ Page 184: “In modern times, with modern medicines, the body’s preprogrammed, and often extreme, inflammatory reaction is not necessary for survival, as pain is no longer a useful signal to remind the brain of your physical limitations. In essence, pain isn’t required to prevent further injury. One of the functions of the endocannabinoid system is to tamp down the inflammatory response. Cannabis has a direct effect on inflammation of all types, from acute to chronic, localized to systemic.5 For example, pain caused by tissue or nerve damage responds well to cannabis’s strong anti-inflammatory action. Even as it works to lower inflammation in one region, there is a positive down- stream benefit that incrementally reduces systemic inflammation: the cannabis lotion you apply to an arthritic knee is going to combat the inflammation at your knee, and as it gradually enters your bloodstream, you may also notice that you feel fewer symptoms of stress. The converse is also true: for those who use cannabinoid therapies as a system-wide anti-inflammatory to treat autoimmune conditions, they also find that their acutely inflamed tissues, such as acne, may improve. What’s more, excessive swelling, which might sometimes shield damaged tissues from further insult, can also unnecessarily delay healing. In the presence of a strong anti-inflammatory medicine like cannabis, extraneous immune elements dissipate while more essential repair elements remain, and a more appropriate response can begin. Many of my patients who are athletes apply lotions to swollen or painful joints for rapid relief and can continue to play their sport with reduced pain. My senior patients with local pain often prefer an edible choice that brings lasting relief. Cannabis therapies can be tolerated by a wide range of people, including those with organ damage (whether due to aging or injury), kidney disease, liver disease, sensitive stomachs, or allergies or aversions to other analgesics.” other FREE resources for cannabis and pain from me: 1. Children and Medical Cannabis: Understanding Therapeutic Potentials and Precautions 2. Cannabis and Chronic Pain: A Comprehensive Guide 3. Medical Cannabis in Palliative Care for Infectious Diseases 4. Cannabis routes of administration, detailed overview 5. Disease Progression and Medical Cannabis 6. Therapeutic Applications of Medical Cannabis in Chronic Genetic Diseases 7. Comparing pain treatments, cannabis and non-cannabis 8. Explaining types of pain and the therapeutic potential of cannabis 9. Comparing pain treatments (cannabis and non-cannabis) 10. Cannabis regimens for pain 11. Effect of Cannabis Terpenes When Inhaled 12. Options in cannabis for treating headaches 13. Comparing Pain Treatments [...] Read more...

5 Transformative Effects of Cannabis Rescheduling: Medical Insight

May 2, 2024In a recent landmark announcement on Cannabis Rescheduling, President Biden expressed his administration’s commitment to support the rescheduling of cannabis from Schedule 1 to Schedule 3 of the Controlled Substances Act. This shift could potentially alter the landscape of cannabis regulation in the United States, impacting everything from medical research to business operations. Schedule 1 Substances: This category includes drugs that are deemed to have “no currently accepted medical use and a high potential for abuse:” 1. Heroin 2. Lysergic acid diethylamide (LSD) 3. 3,4-methylenedioxymethamphetamine (Ecstasy) 4. Methaqualone 5. Peyote 6. Gamma-hydroxybutyric acid (GHB) 7. Bath Salts Schedule 3 Substances: These are drugs with a “moderate to low potential for physical and psychological dependence:” 1. Buprenorphine 2. Codeine and acetaminophen combinations 3. Ketamine 4. Anabolic steroids 5. Testosterone 6. Dronabinol 7. Benzphetamine The goal of this blog is to explore the implications of this potential rescheduling. I’m going to pull apart how such a change could affect different aspects of society, including medical practices, business landscapes, legal frameworks, and public perception. I’m going to sift through both the benefits and concerns, and share an overview of what rescheduling cannabis might mean for different sectors and the broader cultural context. The coming earthquake at the intersection of healthcare and policy I find the topic of cannabis rescheduling particularly fascinating. The momentous shifting of cannabis from Schedule 1 to Schedule 3 in the controlled substances list is not just a simple regulatory change; it’s an epic societal shift with broad implications across our entire culture. Economics, Law, Medicine, Social Life, Parenting, even Schooling will feel the rift of this earthquake, in time. Here, I’m hoping to help readers explore what these changes might mean in a nuanced way, understanding both the opportunities and the challenges that could come. Naturally, nothing like this has ever happened in the modern world, and nothing can truly prepare us. Medical Perspective on Cannabis Rescheduling The medical community stands on the brink of a new era with the rescheduling of cannabis. Here’s how: BENEFITS ➕ Increased Research Opportunities: The move to Schedule 3 would open the doors to more comprehensive research, allowing scientists to explore the therapeutic potentials and side effects of cannabis more freely. ➕ Improved Patient Access: This change could simplify the prescription process, making cannabis more accessible for patients suffering from chronic pain, epilepsy, and other conditions. ➕ Professional Acceptance: As cannabis loses some of its stigma, more healthcare providers may feel comfortable recommending it as a treatment option. ➕ Insurance Coverage: With official recognition, insurance companies might start covering cannabis treatments, which would be a HUGE step forward in patient care. ➕ Regulated Quality Control: Standardized quality control can ensure patient safety, providing consistent, reliable medical cannabis products. Perhaps less of a one state does things …. However, this shift isn’t without its potential pitfalls: CHALLENGES ➕ Regulatory Complexity: Healthcare providers may need to navigate a new set of guidelines which could complicate treatment protocols. ➕ Potential for Misuse: There’s a risk that easier access could lead to misuse or dependency, a concern that medical professionals need to manage carefully. ➕ Cost Implications: The cost for medical cannabis might rise due to the regulatory changes and additional taxes. ➕ Limited Understanding: As a relatively new treatment paradigm, there will be quite a learning curve associated with its use in mainstream medicine. Few doctors are trained with any knowledge of the ECS, and even fewer follow patients to have developed any expertise. ➕ Pharmaceutical Resistance: Traditional pharmaceutical companies will likely push back against the widespread use of cannabis, seeing it as a competitor. They have invested billions in pharmaceutical medicines, hundreds of millions in lobbying efforts, and far less in research & development of cannabinoids. Cannabis Rescheduling, The Business Perspective .…For entrepreneurs and businesses, cannabis rescheduling could be a game-changer: BENEFITS ➕ Market Expansion: Easier federal regulations could pave the way for businesses to expand into new markets. ➕ Banking and Finance: With a lower schedule classification, banks might be more willing to provide services to cannabis-related businesses, easing a significant barrier that has hindered the industry’s growth. ➕ Reduced Legal Risk: A lower risk of federal intervention could stabilize the business environment for cannabis. ➕ Increased Investment: More investors might be drawn to the industry as it sheds some of its legal ambiguity. ➕ Improved Public Perception: As cannabis becomes more mainstream, public perception is likely to shift, potentially increasing customer base. Yet, challenges remain here too: ➕ Regulatory Adjustments: Companies might face new compliance and reporting requirements. ➕ Increased Competition: As the market becomes more accessible, competition will likely intensify. ➕ Taxation: Higher taxes could be implemented as part of the regulatory framework. ➕ Cost of Compliance: Meeting new health and safety standards could drive up costs. ➕ Shift in Consumer Base: Some consumers attracted to the “rebel” nature of cannabis might be put off by its mainstreaming. Overall Sense of What to Expect The potential rescheduling of cannabis from Schedule 1 to Schedule 3 is a complex tapestry of opportunity and challenge. Each sector—from medical to business—will experience its unique set of impacts, and it’s hard to imagine them being either all good or all bad. As we all watch these changes unfold over the next few years (it will take politicians and the US bureaucracies several years to get it all done!), it’s important to approach them with a balanced mindset, appreciating that there will be discussions, arguments, talking heads, and potato heads, on both sides. I will be the first to proudly announce that what I can see of the challenges that lie ahead suggests that we are all woefully unprepared. One specific challenge arises in Medicine, and particularly those medical practices that attract anyone who is either ill or paying attention to modern life -and likely both. As patients begin to ask questions and seek guidance on cannabis from clinicians who may have little to no knowledge about its medical use, they are going to face a very awkward reality. For instance, a patient suffering from chronic pain might inquire about cannabis as an alternative to the traditional pain medications his/her specialist might typically recommend. If cannabis is rescheduled to schedule 3, such inquiries are likely to increase. However, many healthcare providers currently lack the necessary training and certainly lack the experience-based knowledge (which comes from experience counseling and learning from patients over a career) to advise their patients properly about cannabis products, adjustments over time, and expectations, which could lead to misinformed or inadequate patient care, and some unhappy patients, which will likely make its way around to making some very unhappy providers. It is for this reason that CED Clinic has dedicated efforts over the last decade to build resources to educate both patients and healthcare providers alike. Understanding the complexities and potential of cannabis is essential for making informed medical decisions, and everyone wants (deserves!) those. Moreover, resources such as “The Doctor-Approved Cannabis Handbook” play a pivotal role in bridging this Grand Canyon-sized knowledge gap. My handbook serves as a comprehensive, though hopefully simple tool, offering evidence-based guidance that can help navigate both patients and the medical community through the evolving landscape of cannabis treatments. Other tools that I’ve shared over the years include the world’s largest library of free cannabis education, the CED Library, the AI chatbots I’ve been building more recently, the Green Table Talk Podcast I’m in the process of building in order to share patient insights into the every day life of cannabis realities, EO Care, the digital platform that is scaling medical cannabis guidance with curated products, GreenAXS. Capital, a medium-sized post-revenue startup cannabis investment fund, for which I serve as Subject Matter Expert, and a diverse lot of other less public ongoing efforts to help partner and support all types of businesses and institutional efforts to spread knowledge. By arming healthcare providers with an unbiased understanding of the available evidence-based information, we can ensure that the transition towards the rescheduling of cannabis is smooth and beneficial. This will not only enhance the therapeutic outcomes for patients but also solidify the role of informed, scientific guidance in the integration of cannabis into mainstream medical practices. As we move forward, the collective effort of education and adaptation will be key to harnessing the full potential of cannabis rescheduling, turning challenges into opportunities for growth and improvement across various sectors. Learn More: The Doctor-Approved Cannabis Handbook Audiobook Free Cannabis Education CED Clinic Snippet from “The Doctor-Approved Cannabis Handbook“ Page xviii Introduction: “I’m also an advocate, working to raise awareness, share my knowledge, and bring new, effective products to market. As you’ll learn, there’s more to cannabis than THC and CBD: there’s a cornucopia of other molecules in the cannabis plant that should be made more readily available. (While it’s easy to get many of the most basic products, some of the more medicinally beneficial properties remain hard to find in the marketplace, so I will teach you how to make what you need at home: more on that later, too.) Lastly, I’ve had the privilege of collaborating with Howard Kessler, who almost single-handedly created the credit card industry we know today. Howard’s passion matches my own for helping people address the normal ailments of aging that are neglected by modern medicine. Our vision is a complete restructuring of the national approach to medical cannabis. He’s coordinating private/public partnerships for cannabis-based therapies between senior care businesses and the US government toward creating broad, national acceptance. There aren’t many people who could do that, and to have the privilege of playing an educational role in that discussion is a tremendous honor for me to complete my mission. All of this is to say that you’ve come to the right place. While I’m very famil- iar with a wide range of cannabis resources, be assured that you’ve chosen the most authoritative voice in the field. No other website, book, or podcast will match the range and scientific knowledge found in this book. Dispensary agents might have personal experience with cannabis but no formal medical education. Pharmacists are just beginning to become well versed in the literature, but as of this writing there are only nine states that enable pharmacists to serve as educators and dispensers of product: Arkansas, Connecticut, Minnesota, New York, Pennsylvania, Louisiana, Utah, New Hampshire, and Maryland. Instead, you will benefit from my formal medical training, my extensive research, and my clinical experience treating thousands of patients with cannabis, so that you can address your specific needs.” [...] Read more...

Cannabis Mental Health Insights: Navigating Through the Haze

April 26, 2024Introduction The complexities and intersection of cannabis use and its impact on mental health, let’s call that “Cannabis Mental Health,” particularly during the formative adolescent years, is more important than most of us can imagine. Adolescents as well as adults are seeing cannabis everywhere, have access to it like never before, and it is doing real good in unprecedented ways. Just recently, the WHO announced just how central mental health should be in modern wellness, reporting that it is among the most under-addressed illnesses in modern times. Through this lens, we must consider the nuanced findings of recent research that highlights the opportunity for cannabis, and compares it against traditional outlets and vices. The interplay between substance use and mental health issues like depression presents both a challenge and an opportunity for deeper understanding. Here is the new paper, “Testing longitudinal relationships between binge drinking, marijuana use, and depressive symptoms and moderation by sex” by Andra L. Wilkinson, M.S.P.H.a,b, Carolyn Tucker Halpern, Ph.D.a,b, Amy H. Herring, Sc.D.a,c, Meghan Shanahan, Ph.D.b,d, Susan Ennett, Ph.D.e, Jon Hussey, Ph.D.a,b, and Kathleen Mullan Harris, Ph.D.a,f ___ The short-list ( tl;dr, how this relates to medical cannabis) Insights on the Benefits of Medical Cannabis from this review 1. Sexual Dimorphism in the Association Between Binge Drinking and Depressive Symptoms Comment: The finding that the association between binge drinking and depressive symptoms is more pronounced in females highlights the need for sex-specific approaches in both research and treatment. This could influence how medical cannabis is utilized and studied, particularly in how it might serve as an alternative or adjunct therapy in managing depressive symptoms where traditional substances like alcohol have detrimental effects. 2. Adolescents May Self-Medicate Depressive Symptoms with Marijuana Use Comment: The support for the Self-Medication Model across both genders underscores the potential therapeutic benefits of cannabis, particularly in its ability to alleviate depressive symptoms. This raises important considerations for its regulated use in psychiatric settings, emphasizing the need for controlled studies to better understand its benefits and risks. 3. Concurrent Association of Marijuana Use and Binge Drinking with Depressive Symptoms Comment: The notable concurrent association, especially among females, suggests that interventions might need to address both substance use and mental health simultaneously. For medical cannabis, this could mean a focused investigation into its role as a safer alternative to substances that contribute negatively to mental health. 4. Importance of Moderation in Pathways by Sex and Race/Ethnicity Comment: The study’s emphasis on examining variations by sex and race/ethnicity points to a more nuanced understanding of how medical cannabis could be tailored to meet diverse patient needs. This calls for inclusive research designs that consider these factors to optimize therapeutic outcomes. 5. Greater Applicability of the Stress Model for Females Comment: This finding enhances our understanding of gender differences in substance use impact, suggesting that medical cannabis interventions could be specifically designed to mitigate stress-induced depressive symptoms in females. 6. Depression Predicting Marijuana Use in African American Adolescents Comment: The specific evidence from African American adolescents highlights the critical need for targeted research into how cannabis affects different demographics. It suggests that medical cannabis might be particularly beneficial in these communities if integrated responsibly and with cultural competence. 7. Non-Support for Self-Medication with Binge Drinking Comment: The lack of support for binge drinking as a form of self-medication reaffirms the potential role of safer alternatives like medical cannabis. This finding could help shift public and medical perspectives towards more beneficial and less harmful therapeutic options. 8. Utilization of Nationally Representative Longitudinal Data Comment: The use of robust, representative data strengthens the reliability of findings regarding cannabis and its effects, providing a solid foundation for advocating for medical cannabis research and its integration into clinical practice. 9. Screening Recommendations Based on Study Findings Comment: The recommendation for dual screening of depression and substance use could lead to earlier and more comprehensive treatment approaches. Including medical cannabis as part of this screening could help identify potential candidates for whom cannabis might offer therapeutic benefits. 10. Emphasis on Tailored Interventions and Continued Research Comment: The study’s call for tailored interventions reflects a growing recognition of the complex interplay between substance use and mental health. It underscores the necessity of continued research into how medical cannabis can be effectively and safely integrated into treatment protocols. _____ Understanding the Dual Models A new landmark study by Wilkinson et al. (2016) provides a robust framework for examining this interplay through two theoretical models: the Self-Medication Model and the Stress Model. These models help elucidate the directionalities of the relationship between cannabis use and depressive symptoms, particularly how these interactions are moderated by sex. The Self-Medication Model According to the Self-Medication Model, individuals may turn to substances like marijuana as a way to lessen their depressive symptoms. It’s a concept that sees individuals attempting to manage their emotional pain with the tools available to them, albeit not always the healthiest options. The recent study strengthens this model by demonstrating a notable increase in marijuana usage as depressive symptoms escalate from adolescence into young adulthood. This pattern wasn’t just isolated to one gender; it appeared across the board, suggesting that the inclination to self-medicate is a common human response regardless of gender. This finding encourages us to consider how medical cannabis might be harnessed responsibly to provide relief without the downsides of unregulated substance use. The Stress Model On the flip side, the Stress Model offers a stark contrast, proposing that substance use doesn’t soothe but rather sparks or worsens depressive symptoms. This connection was especially strong among females in the study, shedding light on how substance use might amplify emotional distress more so in women than in men. This suggests a gender-specific vulnerability to the negative impacts of unmoderated substance use. Recognizing these differences is crucial for developing targeted treatments that not only address the root causes of substance use but also provide protective measures against its potential to aggravate existing mental health issues. The implications for medical cannabis are profound, highlighting the need for gender-sensitive research and approaches in its application for mental health treatment. Examining the Evidence The study draws on data from the National Longitudinal Study of Adolescent to Adult Health, analyzing the trajectory of substance use and depressive symptoms over time. The findings suggest that increases in marijuana use are consistently associated with an increase in depressive symptoms, especially among females. This supports the Stress Model, positing that substance use can indeed be a precursor to, or a catalyst for, depressive episodes. Highlighting Disparities and Future Directions While the study confirms some aspects of both theoretical models, it also highlights significant sex differences in how these processes operate. For instance, females showed stronger concurrent associations between substance use frequency and depressive symptoms, suggesting a gender-specific preventive approach could be beneficial. Integrating Broader Findings The insights from this study are echoed across the broader landscape of adolescent mental health research. It has been well-documented that a significant portion of the youth population—nearly one in five adolescents—experiences major depressive episodes during their formative years. This statistic alone highlights the prevalence and the severity of mental health challenges among teenagers. More telling, however, is the fact that those who experience these depressive episodes are significantly more likely to engage in marijuana use, with reports suggesting that they are twice as likely to use marijuana compared to their peers who do not suffer from depression . This correlation between depression and increased substance use underpins the complex interplay of mental health issues and substance use behaviors, often referred to as comorbidity. The relationship suggests that many young individuals might be attempting to manage their symptoms via substances that are accessible but potentially harmful. This comorbidity not only complicates treatment approaches but also worsens the long-term prognosis for these adolescents if not properly addressed. Recognizing this, the Affordable Care Act (ACA) includes important provisions for preventive mental health care that could be crucial for addressing these challenges . The ACA advocates for comprehensive screening and preventive services, which are aimed at early identification and intervention for mental health issues in young populations. By integrating these services into regular health care practices, it is possible to identify at-risk youths early and provide them with the necessary support and treatment before their symptoms escalate into more severe conditions or lead to substance dependency. Thus, the need for integrated screening and preventive services is more pressing than ever. Effective implementation of these measures could significantly alter the trajectory of mental health care for adolescents, providing a framework that supports early intervention and comprehensive care strategies. This approach not only aligns with the ACA’s health care objectives but also sets a standard for future health care policies aimed at mitigating the impact of mental health issues and substance use among the younger populations. The Role of Digital Health Platforms In the context of the complex interplay between cannabis use and mental health, digital health platforms such as EO Care are emerging as critical tools in the healthcare landscape. These platforms harness the power of technology to provide scalable, data-driven solutions that can be customized to individual needs. By integrating clinical data, patient-reported outcomes, and research insights, platforms like EO Care facilitate a more nuanced approach to health management. This enables healthcare providers to deliver more precise and informed care, enhancing patient engagement and adherence to treatment plans. Digital health platforms are particularly valuable in areas like cannabis medicine, where the need for education and accurate patient monitoring is critical due to the varying effects of cannabis on different individuals . Conclusion Our journey through the intertwined areas of cannabis use and mental health uncovers a terrain filled with both hurdles and possibilities. The insights we’ve gained underscore the importance of bespoke healthcare interventions tailored to meet the unique needs of each patient. As we refine our comprehension of these complex relationships, the necessity for nuanced, research-backed approaches in both clinical and investigative spheres becomes apparent. The future of cannabis-related healthcare lies in the ability to adapt and respond to individual circumstances, paving the way for more effective and personalized treatment modalities in mental health care. Snippet from “The Doctor-Approved Cannabis Handbook“ Page 119: “While we might think about our feelings, moods, and emotions as intangible and impermanent states of mind, addressing concerns surrounding them turns out to be a solvable and tangible endeavor. Our emotional life, including the highs and the lows, is governed by cascades of chemistry that communicate messages from one brain region to the next. Like flowing water that carves deep channels in the ground, over time these chemical signals create strong, committed patterns of thought and emotion. For instance, your emotional response to crisis may always look like increased attention and anxiety, or, if you’re battling daily stressors, toward the end of the day, you may regularly embrace the opportunity for calmness and a desire to retreat into a place of security. When your mental health is strong, you can operate through the world at your peak, and you’re more resilient when facing daily stumbling blocks. But when your day-to-day life is hindered by an inability to control your thoughts or emotions, I know that it can be debilitating. However, you don’t have to suffer—or take medications with intolerable side effects. I’ve found that while cannabis works best when paired with other medications, it can also work well as a singular tool for address- ing a wide variety of mental health issues. I’ve seen people with crippling PTSD, incapacitating anxiety, intense depression, and frustrating ADHD effectively address these issues and resume their lives. For some, the change is rapid and dramatic.” Further Reading For more on cannabis and mental health, check out this discussion from last year. For more on heart health: Here and here Check out More on this topic at CaplanCannabis.com Kessler R, McGonagle K, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Arch Gen Psychiatry1. 1994; 51:8–19. Link. Substance Abuse and Mental Health Services Administration. Results from the 2013 National Survey on Drug Use and Health: Mental Health Findings. Published 2014. Link. United States Department of Health and Human Services. Preventive services covered under the Affordable Care Act. Published 2012. Link. Hilty, D. M., Ferrer, D. C., Parish, M. B., Johnston, B., Callahan, E. J., & Yellowlees, P. M. (2013). The effectiveness of telemental health: a 2013 review. Telemedicine and e-Health, 19(6), 444-454. This source provides insights into the effectiveness of digital health platforms in delivering mental health services, which can be extrapolated to understand the potential of platforms like EO Care in the realm of cannabis-related mental health treatment. 5. Firth, J., Torous, J., Nicholas, J., Carney, R., Pratap, A., Rosenbaum, S., & Sarris, J. (2017). The efficacy of smartphone-based mental health interventions for depressive symptoms: a meta-analysis of randomized controlled trials. World Psychiatry, 16(3), 287-298. This meta-analysis offers evidence on the efficacy of digital health interventions on depressive symptoms, supporting the argument for integrating such technologies into mental health and substance use treatment plans. 6. Ashford, R. D., Brown, A. M., & Curtis, B. (2018). Technology-based interventions for substance use and comorbid disorders: An examination of the emerging literature. Harvard Review of Psychiatry, 26(4), 204-215. This review discusses the current state of technology-based interventions for substance use disorders and their co-occurring conditions, relevant to the discussion on cannabis use and mental health. 7. Campbell, A. N. C., Nunes, E. V., Matthews, A. G., Stitzer, M., Miele, G. M., Polsky, D., … & Turrigiano, E. (2014). Internet-delivered treatment for substance abuse: a multisite randomized controlled trial. The American Journal of Psychiatry, 171(6), 683-690. This randomized controlled trial provides evidence on the effectiveness of internet-delivered treatments for substance abuse, which can bolster the case for digital platforms like EO Care in providing similar services for cannabis-related treatments. 8. López-Pérez, B., Wilson, E. L., Dellinger, K., & Gulliford, L. (2020). The costs and benefits of healthcare information technology: An updated systematic review. Journal of Medical Internet Research, 22(9), e23844. This systematic review updates on the costs and benefits of healthcare information technology, which is crucial for understanding the economic and clinical viability of digital health platforms in the context discussed. [...] Read more...

Awful Business Practices Eroding Trust and Medical Cannabis Ethics: The Case of Medwell and DocMJ

April 25, 2024Medical Cannabis Ethics and Industry Integrity This post comes in follow up of this previous post here In the rapidly expanding field of medical cannabis, the significance of medical cannabis ethics and the quality of patient care cannot be overstated. However, organizations like Medwell and DocMJ have displayed a troubling trend of prioritizing profits at the expense of patient-centered care. This approach not only tarnishes the reputations of such companies but also casts a shadow over the legitimacy of the medical cannabis industry as a whole. The recent settlement involving Physician Compassionate Care, operating as DocMJ, where they agreed to pay over $736,000 to resolve allegations of sending spam text messages to consumers, is a case in point. This incident under the Telephone Consumer Protection Act (TCPA) reflects broader ethical concerns. It illustrates a model of operation where the focus is on maximizing client intake through aggressive marketing tactics rather than providing genuine medical advice and follow-up care. This case is particularly significant because it not only reflects non-compliance with federal regulations but also indicates a disregard for the personal and sensitive nature of patient communications in healthcare. Effective and ethical medical cannabis care should involve personalized consultations, tailored treatment plans, and privacy-respecting communication—qualities that are evidently lacking in these high-volume, low-engagement business models. Moreover, treating medical marijuana recommendations as quick transactions undermines the critical role of comprehensive patient evaluations. Such evaluations are essential to ensure that cannabis treatment is appropriate, safe, and beneficial in the context of a patient’s overall health status and other treatments. This conveyor-belt approach to medical recommendations can lead to inadequate patient education on the use of cannabis, potential drug interactions, and management of side effects, which are crucial components of safe cannabis therapy. The impact of these practices extends beyond individual patient experiences. They erode trust in the medical cannabis industry, which is still fighting stigmas and striving for acceptance within broader medical and patient communities. As more states legalize medical cannabis and more patients seek cannabis-based treatments, it is imperative that the industry is seen as credible and trustworthy. For the medical cannabis sector to maintain its integrity and continue to grow in a positive direction, it is vital for all involved to adhere to high standards of medical cannabis ethics and ethical business practices. Patients should be treated with respect and care, receiving not just a prescription but a thorough understanding of their treatment. This ensures not only compliance with legal standards but also fosters a positive perception of cannabis as a legitimate medical option. As the industry evolves, it becomes increasingly important to spotlight and challenge the practices of companies that diminish its credibility. By demanding higher standards and choosing providers wisely, patients and advocates can help shape an industry that truly prioritizes health and care over profit. Quality of Care at Stake At CED Clinic, we often encounter patients who have previously engaged with services like those offered by Medwell and DocMJ. These patients frequently report a stark lack of follow-up or genuine care from these providers. Medwell, for instance, is known among some circles more for its rapid issuance of medical marijuana cards than for its patient care. This ‘card flipping’ approach neglects the essential standards of medical cannabis ethics, including understanding a patient’s complete health profile and ensuring their treatment aligns with their specific medical needs. The practice of spamming potential patients with text messages further underscores the impersonal and transactional nature of these businesses. It’s hard to imagine a reputable medical institution adopting such invasive marketing tactics. Would you trust your health to a provider whose main communication method is akin to that of a relentless sales campaign? The Hidden Costs of Discounted Medical Marijuana Cards: Quality Care vs. Quick Deals The appeal of low-cost medical marijuana cards can be tempting, especially to those seeking relief on a budget. However, as with many things in life, cheaper options often come with hidden costs. This is particularly true in the realm of medical cannabis, where the complexity and delicacy of treatments necessitate a high level of care and expertise. Fast Food vs. Fine Dining: A Health and Quality Comparison Just as fast food offers a quick, inexpensive meal at the cost of nutritional value and dining experience, discounted medical marijuana cards typically offer a rapid approval process at the expense of thorough medical oversight. Fast food, while convenient and economical, often leads to long-term health consequences and lacks the culinary satisfaction of a meal prepared with care and expertise. Similarly, the quick and impersonal service provided by some low-cost cannabis card services can result in inadequate patient education, improper dosage recommendations, and a lack of follow-up care, which are vital for safe and effective cannabis treatment. The experience of consulting with a dedicated, knowledgeable professional who takes the time to understand and address individual health needs is akin to dining at a fine restaurant. The attention to detail, the ambiance, and the quality of service enhance the overall experience and contribute positively to one’s well-being. This level of care and interaction is often missing when services are stripped to their bare minimum in the name of cost-saving. The Benefits of Fair Compensation for Healthcare Professionals Investing in quality healthcare services by paying clinicians a fair wage yields significant benefits. It motivates professionals to deepen their expertise, stay updated with the latest research, and develop better care protocols. In the medical cannabis field, where ongoing research and patient feedback are crucial to optimizing treatment plans, the value of informed and engaged healthcare providers cannot be underestimated. Fair compensation also fosters a sense of value and respect within the profession, which is essential for attracting skilled practitioners to the field of medical cannabis. When clinicians are paid well, they are more likely to invest time in patient education, engage in community outreach, and contribute to the advancement of the field through research and innovation. Moreover, well-compensated professionals are generally more motivated to provide personalized care and follow-up, ensuring that patients receive comprehensive support throughout their treatment journey. This not only improves patient outcomes but also enhances patient satisfaction and trust in medical cannabis as a legitimate therapeutic option. Prioritizing Quality over Cost in Cannabis Medicine Ultimately, the choice between a discounted medical marijuana card and a more costly, comprehensive care option should consider more than just the immediate financial outlay. The long-term health benefits, the quality of medical advice, and the ongoing support system are crucial factors that can significantly influence treatment efficacy and patient safety. Patients and healthcare systems alike would benefit from viewing medical cannabis care as an investment in health rather than an expense to be minimized. By choosing providers who offer detailed consultations, continuous education, and robust follow-up, patients can ensure they receive the best possible care—maximizing the therapeutic potential of cannabis while minimizing risks. In conclusion, while the allure of cheap medical marijuana cards is understandable, the real cost of such services often extends beyond the initial savings, affecting both patient health and the overall quality of care. Investing in high-quality medical cannabis care, therefore, not only supports individual health outcomes but also contributes to the legitimacy and growth of the entire field. A Call for Higher Standards This situation serves as a reminder of the need for higher standards within the medical marijuana industry. Companies involved in this sector must not only comply with all regulatory requirements but should also strive to uphold the dignity and integrity of medical practice. Patients seeking medical cannabis deserve the same level of professional care and consideration that is expected in any other medical context. CED Clinic: A Beacon of Excellence in Cannabis Medicine As the medical cannabis industry expands, the importance of supporting institutions that uphold high standards of quality, ethics, and patient-centric care becomes ever more crucial. CED Clinic exemplifies such dedication, continuously pushing the boundaries of cannabis medicine through meticulous patient care, extensive educational efforts, and a deep commitment to enhancing patient well-being. Personalized Care and Lasting Relationships At CED Clinic, we believe that effective medical treatment goes beyond the initial consultation. We invest time in each patient, ensuring they receive as much attention as necessary to address their unique health concerns. This approach allows us to develop personal relationships with every patient, fostering a trusting and supportive environment that is conducive to healing. Our healthcare providers are consistent figures in our patients’ medical journeys. Some of these professional relationships span years, and in some cases, decades. This continuity of care is not just about maintaining a standard of treatment; it’s about deepening the understanding of each patient’s evolving needs and experiences. By following our patients over time, we learn about their challenges and victories, gathering insights that help refine our care strategies and improve outcomes. Building on Therapeutic Relationships CED Clinic is built on the foundation of therapeutic relationships, which are not only central to our philosophy but are also supported by evidence as being critical to ideal healing outcomes. These relationships create a safe space for patients to discuss their concerns and experiences openly, ensuring that treatments are adapted to real-world effects and patient feedback. Our commitment to these principles is reflected in every interaction within our clinics. From detailed initial assessments to ongoing management and follow-up, each step in our process is designed to strengthen the doctor-patient relationship, enhance trust, and promote a holistic approach to health. Education as a Pillar of Care Comprehensive education is another cornerstone of our practice at CED Clinic. We strive to empower our patients with the knowledge they need to make informed decisions about their treatment options. Our educational efforts extend beyond the individual, reaching out to the community to increase awareness about the benefits and complexities of cannabis as a medical treatment. This not only aids in demystifying cannabis use but also helps elevate the discourse surrounding cannabis medicine, promoting a more informed and accepting public perspective. As the landscape of medical cannabis continues to evolve, CED Clinic remains steadfast in its mission to provide top-notch cannabis care grounded in ethical practices and patient-centered approaches. We continue to advocate for and embody the kind of healthcare that not only treats but truly cares and connects with each patient. Through ongoing dedication to these values, CED Clinic stands as a leader in the field, advocating for a future where medical cannabis is recognized as a vital and viable part of healthcare. Navigating Your Choices in Medical Marijuana Care Choosing a medical marijuana provider is a decision that should be approached with care and consideration. It’s not merely about obtaining legal access to cannabis; it’s about forming a partnership with a healthcare provider who truly values your well-being and is committed to the long-term management of your health. Seek Providers Committed to Comprehensive Care When selecting a medical cannabis provider, look for clinics that prioritize holistic, evidence-based care. These providers take the time to understand not just your symptoms, but your overall lifestyle, health history, and treatment goals. They should offer comprehensive assessments that go beyond the surface, ensuring that the cannabis treatment plan is not only effective but also safe given your unique health circumstances. Follow-Up: A Key Component of Effective Treatment Continuity of care is crucial. Your provider should have a robust system in place for following up on your treatment. This means regular check-ins to assess the efficacy of the cannabis regimen, adjustments based on your feedback, and ongoing support to address any side effects or concerns that may arise. Providers who invest in follow-up care demonstrate their commitment to your health outcomes and are more likely to deliver personalized care that adapts to your evolving needs. Holistic and Patient-Centered Approaches Ideal cannabis medicine providers integrate holistic approaches that consider the full spectrum of physical, emotional, and lifestyle factors affecting your health. They should work collaboratively with you to explore all available treatment options, including complementary therapies that can enhance the effectiveness of cannabis. This patient-centered approach ensures that care plans are not only targeted but also aligned with your personal health goals and preferences. Prioritize Quality and Ethical Practices It’s essential to choose a provider who views your health as more than just a transaction. Ethical practices in medical cannabis care are indicative of a provider’s dedication to the field and to their patients. Research potential providers, read reviews, and perhaps most importantly, schedule a consultation to discuss their approach to care. This initial interaction can provide significant insight into how they value patient relationships and whether they prioritize quality care. Making Informed Decisions Finally, remember that the quality of service you receive can significantly impact your treatment outcomes. Providers who are knowledgeable, transparent about the benefits and risks of cannabis, and attentive to your needs will contribute positively to your treatment experience. These providers will not only guide you through the initial phases of cannabis treatment but will be your partners in long-term health management. Choosing the right medical marijuana provider is crucial for ensuring that you receive the best possible care. By prioritizing quality, comprehensive care, and ethical practices, you can make an informed decision that aligns with your health needs and ensures a supportive, effective treatment journey. References Barnes, M. P. (2018). “The importance of high-quality care in medicinal cannabis.” Journal of Clinical Pharmacy and Therapeutics, 43(6), 848-850. This article discusses the critical need for high-quality care in the prescription and management of medicinal cannabis, emphasizing the complexities and nuances in patient care that require detailed attention from healthcare providers. Haug, N. A., Kieschnick, D., Sottile, J. E., Babson, K. A., Vandrey, R., & Bonn-Miller, M. O. (2017). “Training and Practices of Cannabis Dispensary Staff.” Cannabis and Cannabinoid Research, 2(1), 298-305. This study highlights the variability in training and knowledge among cannabis dispensary staff, suggesting a gap in the quality of patient education and guidance, which can significantly affect patient outcomes. Ziemianski, D., Capler, R., Tekanoff, R., Lacasse, A., Luconi, F., Ware, M. A. (2016). “Cannabis in medicine: a national educational needs assessment among Canadian physicians.” BMC Medical Education, 16, 107. This research outlines the educational gaps among physicians regarding medical cannabis, stressing the importance of comprehensive healthcare provider education to ensure high-quality patient care. Blair, S., & Hall, B. (2016). “An investigation of patient motivations for their use of medical cannabis and barriers to healthcare in medical cannabis patients.” Complementary Therapies in Medicine, 26, 108-111. The paper explores patient motivations for using medical cannabis and identifies significant barriers to high-quality care, including inconsistent consultation practices and limited follow-up. Corroon, J., Mischley, L. K., & Sexton, M. (2017). “Cannabis as a substitute for prescription drugs – a cross-sectional study.” The Journal of Pain Research, 10, 989-998. This cross-sectional study provides insight into how patients substitute cannabis for prescription drugs and the need for quality control and professional guidance to manage such substitutions safely and effectively. [...] Read more...

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Cannabis Recipes

Cannabis Green Cream Soup Recipe

August 3, 2023This soup can be enhanced with any of your favorite vegetables. Materials Soup Pot Frying Pan Hand-Blender or Regular blender (optional) Ingredients 3 cups vegetable stock 1 cup chopped broccoli 1/2 red onion, chopped 2 stalks of celery, chopped 1 and 1/2 cup heavy cream (canna-cream may be substituted or blended with regular cream for increased potency) 2 TBSP olive oil Fresh cilantro (optional) Salt and Pepper to taste Canna-Oil (dose-dependent) Directions 1. Heat vegetable stock and broccoli in a large pot Boil for around 6 minutes 2. On another burner, saute garlic, onion and celery in olive oil until soft — about 4 minutes 3. Take the pan off the heat and add desired dose of canna-oil to vegetables Stir thoroughly and then pour mixture in to the big soup pot Be sure to scrape all material to get the maximum amount of canna-oil 4. Heat for another 6–8 minutes then reduce heat to low and add heavy cream, add salt and pepper to taste 5. Let simmer for 5 minutes, serve hot Garnish with cilantro if desired This recipe is available for download HERE The original recipe is from Royal Queen Seeds [...] Read more...

Cannabis Milk Recipe

August 3, 2023This recipe may be used with heavy cream or whole milk. Materials -Medium Sauce-Pan -Thermometer -Mesh-sieve or cheesecloth Ingredients 6 grams cannabis flower 2 cups whole milk or heavy cream Directions 1. Decarboxylate the cannabis Heat the oven to 225°F. Spread cannabis buds out into an even layer on a baking sheet and place in the oven. Take care not to let the temperature go over 225°F and burn (if this happens, you can lose potency). Bake for about 35–40 minutes, then remove from the oven and cool before grinding into a coarse powder. The decarboxylated cannabis will keep in an airtight container in a cool, dark place for up to 2 months 2. Heat the milk or heavy cream, in a saucepan over medium-low heat. Add the decarboxylated cannabis and cook, taking care not to let the temperature go over 200°F for about 45 minutes. 3. Remove from heat and let sit, undisturbed, for 10 minutes 4. Strain through a fine mesh-sieve set over a bowl. Press carefully with a spoon to extract as much oil as possible The milk will keep for up to 6 weeks if covered and refrigerated. This recipe is available for download HERE Original recipe from Vice.com [...] Read more...

Cannabis Tacos Recipe

August 3, 2023Ingredients 2 cups shredded green cabbage 1 Tbsp lime juice 1/2 Tsp salt 3 Tbsp cilantro 1/4 cup canna-oil 1 tomato, diced 1/2 cup salsa 1/2 onion, diced 1 jalapeno, diced 1 avocado, sliced Meat of choice (fish or a ground meat like beef or turkey) 4 corn tortillas Directions 1. Cook choice of meat with fajita seasoning in frying pan, set aside 2. In a large bowl, mix shredded cabbage, line juice, salt and cilantro 3. In a separate bowl, mix canna-oil with tomato, onion, jalapeno and salsa 4. Wrap the tortillas in paper towels and heat in the microwave for 30 seconds, or until warm 5. Fill each tortilla with meat, cabbage mixture, cannabis salsa mixture and diced avocado Serve with lime wedge The recipe is available for download HERE Original recipe from Eat Your Cannabis [...] Read more...

Cannabis French Fries Recipe

August 3, 2023Ingredients 2/3 cup Cannabis oil (coconut or olive oil will work) 4 large potatoes peeled 3 tbsp salt Instructions Preheat your oven to 400 degrees Fahrenheit and line a large baking sheet with parchment paper. Cut your peeled potatoes into strips (cut them into fries!) and spread them evenly on the baking sheet. Drizzle the cannabis-infused oil over them and season with salt. Try to coat each fry relatively evenly with the oil so that there is a consistent potency. Cook the fries until they are golden brown. Around 15–20 minutes. Allow the fires to cool down, around 5 minutes. Divide the fries into equal proportions and serve. This recipe is available for download HERE Original recipe from thecannaschool.com [...] Read more...

Cannabis Shakshuka Recipe

August 3, 2023Ingredients 1 can whole peeled tomatoes 28 oz. 1 jar roasted red peppers 12 oz. 4 large eggs ½ cup plain Greek yogurt ¼ cup CannaOil plus more for drizzling 1 teaspoon coriander seeds 1 teaspoon cumin seeds 6 garlic cloves divided 2 medium shallots divided Kosher salt Freshly ground black pepper Mint leaves and crusty bread for serving Crush coriander and cumin seeds, pressing down firmly with even pressure. Transfer seeds to a small heatproof bowl. Slice 2 garlic cloves as thinly and evenly as you can; add to bowl with seeds. Finely chop the remaining 4 garlic cloves. Cut half of 1 shallot into thin rounds and then add to the same bowl with seeds and garlic. Chop remaining shallots. Open a jar of red peppers and pour off any liquid. Remove peppers and coarsely chop. Combine ¼ cup oil and seed/garlic/shallot mix in the skillet you used for crushing seeds. Heat over medium and cook, stirring constantly with a wooden spoon, until seeds are sizzling and fragrant and garlic and shallots are crisp and golden, about 3 minutes. Place a strainer over the same heatproof bowl and pour in the contents of the skillet, making sure to scrape in seeds and other solids. Do this quickly before garlic or shallots start to burn. Reserve oil. Spread out seed mixture across paper towels to cool. Season with salt and pepper. Return strained CannaOil to skillet and heat over medium. Add remaining chopped garlic and shallot and cook, stirring often, until shallot is translucent and starting to turn brown around the edges, about 5 minutes. Season with salt and lots of pepper. Add chopped peppers to the skillet and stir to incorporate. Using your hands, lift whole peeled tomatoes out of the can, leaving behind tomato liquid, and crush up with your hands as you add to the skillet. Discard leftover liquid. Season with more salt and pepper. Cook shakshuka, stirring often, until thickened and no longer runs together when a spoon is dragged through, 10–12 minutes. Reduce heat to low. Using the back of a wooden spoon, create four 2″-wide nests in tomato sauce. Working one at a time, carefully crack an egg into each nest. Cover skillet and cook, simmering very gently and reducing heat if necessary, until whites of eggs are set while yolks are still jammy, 7–10 minutes. Uncover skillet and remove from heat. Season tops of eggs with salt and pepper. Top shakshuka with dollops of yogurt, sprinkle with seed mixture, then drizzle with more olive oil. Finish by scattering mint leaves over top. Serve pita or crusty bread alongside. This recipe is available for download HERE Original recipe from eat your cannabis.com [...] Read more...

Cannabis Hummus Recipe

August 3, 2023Ingredients blender ¼ cup tahini ¼ cup lemon juice, freshly squeezed w/o seeds 15 ounce can of chickpeas, drained and rinsed 2 garlic cloves ¼ cup CannaOil ½ cup ground cumin 2 tablespoons water salt and pepper to taste Instructions Combine lemon juice and tahini in a blender. Blend for 30 seconds. Add chickpeas, garlic, Canna Oil, cumin and water. Blend for 1 minute until smooth. Add more water if needed to reach desired consistency. Pour hummus in a serving bowl, or store in the refrigerator for later. This recipe is available for download HERE Original recipe from eatyourcannabis.com [...] Read more...

Cannabis Confetti Cupcakes Recipe

August 3, 2023Ingredients Cupcakes: 2 cups flour 1 cup sugar 1 Tbsp baking powder 1/4 Tsp salt 1 cup milk 2 eggs 1/4 cup canna-oil (vegetable is best) 1/4 vegetable oil 2 Tsp vanilla extract 1/3 cup rainbow sprinkles Frosting: 1 cup sugar 1 cup egg whites 1lb butter, salted, room temperature 1 Tsp vanilla extract Directions Cupcakes: Preheat oven to 350°F. Line a cupcake pan with cupcake liners. Mix all of the dry ingredients together in a medium bowl. Whisk all of the liquid ingredients together until blended. Add the liquid ingredients to the dry ingredients & mix until there are no large lumps. Do not overmix. Gently stir in the rainbow sprinkles until just blended. Use a 2-ounce portion scoop & fill each cupcake liner with one scoop. Bake for 15–18 minutes or until a toothpick inserted in the middle comes out clean. Remove from the oven & allow to cool a bit before removing them from the pan. Frosting: Put 2 inches of water into a medium-size pot, & bring to a boil. Place the sugar & egg whites into a small stainless bowl that will sit on top of the pot of boiling water, or use a double boiler system. DO NOT allow the bowl with the egg white mixture to directly touch the boiling water or the egg whites will cook very quickly. Whisk constantly until temperature reaches 140°F/60°C or until the sugar has completely dissolved & the egg whites are hot to the touch. DO NOT leave unattended or you will have a sweet egg white scramble! Use a hand mixer or pour the egg white mixture into a bowl that is fitted for a stand mixer. Using the whisk attachment, begin to whip until the meringue is thick & glossy, about 10 minutes on medium-high. Place the mixer on low speed, add the cubes of butter, a couple at a time, until incorporated. Continue beating until it has reached a silky smooth texture. If the buttercream curdles simply keep mixing & it will become smooth. If the buttercream is too runny, refrigerate for about 15 minutes before continuing mixing. Add the vanilla & continue to beat on low speed until well combined. Once the cupcakes have completely cooled, place a large star tip into a piping bag & fill with the buttercream. Pipe a rosette onto each cupcake & add the sprinkles on top. Serve immediately, the same day or keep in an airtight container in the fridge for up to 4 days. They can also be frozen for up to 3 months. This recipe is available for download HERE Original recipe from myedibleschef.com [...] Read more...

Cannabis Omelette Recipe

August 3, 2023This recipe can be used with your favorite vegetables and breakfast meats Ingredients Base: 4 large eggs salt and pepper (to tasste) 1 tbsp butter (canna-butter may be used to increase potency) 1/2 cup canna-milk Filling: 2 tbsp diced green pepper 2 tbsp diced green onion 2 tbsp ham or meat of your choice 1/4 cup shredded cheese Instructions 1. Beat eggs in a bowl with a whisk. 2. Add canna-milk and season with salt and pepper 3. Add any vegetables and/or meat fillings to the eggs and whisk for a few minutes until egg mixture if foamy — beating in air makes the omelette fluffy 4. Melt butter in a small, nonstick skillet over medium-low heat. Pour in egg mixture and twirl skillet so the bottom is evenly covered in egg. 5. Cook until egg starts to set. Lift the edges with a spatula and tilt the skillet so uncooked egg mixture can run towards the bottom of the skillet to set Repeat until no visible liquid egg remains 6. Carefully flip omelette and cook another 30 seconds to 1 minute 7. Sprinkle cheese in one line in the middle of the omelette and fold it in half, cook another 20 seconds them slide the omelette on to the plate This recipe is available for download HERE Original recipe from the Canna School [...] Read more...

Cannabis Waffles Recipe

August 3, 2023Ingredients 2 cups all-purpose flour 4 Tbsp sugar (canna-sugar may be substituted to increase potency) 1 Tbsp baking powder ½ Tsp salt 2 large eggs 1 ½ cups whole milk (canna-milk may be substituted to increase potency) ¾ cup canna-butter, melted 1 teaspoon vanilla extract Instructions 1. In a bowl, combine dry ingredients: flour, sugar, salt, baking powder 2. In another bowl, combine wet ingredients: beat the eggs with the milk, then add the vanilla extract 3. Stir the wet ingredients into the dry ingredients until just combined Do not over-mix, batter will be thick and slightly lumpy 4. Bake in a preheated waffle-iron according to manufacturer’s directions until golden brown This recipe is available for download HERE! Original recipe from allrecipes.com [...] Read more...

Cannabis-infused Mayonnaise

August 3, 2023Servings: 12 Ingredients 1 cup soybean oil ½ ounce ganja shake 2 large egg yolks 1 teaspoon fresh lemon juice Pinch of salt 1 teaspoon white vinegar ½ teaspoon Dijon mustard Directions In a double boiler, combine the oil and ganja. Heat over low until the ganja smell is pronounced but not nutty or burnt. (The oil should have an earthy green tint to it.) Let cool. Remove and strain the herb, squeezing the weed in a metal strainer against the mesh with the back of a spoon to wring out every drop of oil. Make sure that all your ingredients have been brought to room temperature — this is crucial! In a small metal bowl, use an immersion blender or whisk to thoroughly blend the egg yolks, lemon juice, salt, vinegar, and mustard. This can also be done in a food processor or blender. Using a ½ teaspoon measure, very slowly add the infused oil to the small metal bowl, a few drops at a time, while constantly blending on low or whisking until the mayo is thick and starting to form ribbons. (If it’s too thick, you can add room-temperature water in tiny increments.) If your mixture “breaks,” it can be repaired by whisking some more room-temperature egg yolks in a separate bowl, then slowly whisking those yolks into the “broken” mayo mixture. If that doesn’t do it, add a few drops of hot water. Cover and chill; it’ll keep in the refrigerator for 4 to 5 days. Original recipe from: Boudreaux, Ashley. The Official High Times Cannabis Cookbook. Red Eyed Deviled Eggs. https://saltonverde.com/wp-content/uploads/2017/09/10-High_Times_Cannabis_Cookbook.pdf [...] Read more...

Cannabis Pumpkin Spice Cupcakes Recipe

August 3, 2023Ingredients 4 eggs 1 cup white sugar ½ cup brown sugar, packed 1 ¼ cups grapeseed oil ¼ cup canna-oil 2 tsp vanilla extract 1 ¾ cups pure pumpkin puree 3 cups all-purpose flour 1 tbsp ground cinnamon 1 tbsp pumpkin spice 2 tsp baking powder 2 tsp baking soda 1 tbsp orange zest, optional Directions Preheat the oven to 350°F/175°C. Line a jumbo muffin tin with liners. Place the eggs, white sugar, brown sugar, grapeseed oil & canna-oil into a bowl fitted for a stand mixer or use a whisk to thoroughly beat ingredients together. Blend in the pumpkin & vanilla extract. In a small bowl mix the dry ingredients together. Add to the wet ingredients & mix until just blended. Stir in the orange zest (optional). Divide the batter evenly between 12 muffin cups using a muffin scoop, about 3 ounces each. Sprinkle with pumpkin seeds. Bake for 22–25 minutes or until a toothpick inserted into the middle comes out clean. Allow to cool, remove from the tins & sprinkle with cinnamon. This recipe is available for download HERE Original recipe from myedibleschef.com [...] Read more...

Cannabis Oil Recipe

August 3, 2023Materials -Medium Sauce-Pan -Thermometer -Mesh-sieve or cheesecloth Ingredients -6 grams cannabis flower -2 cups oil (olive, coconut, canola or vegetable oil) Directions 1. Decarboxylate the cannabis Heat the oven to 225°F. Spread cannabis buds out into an even layer on a baking sheet and place in the oven. Take care not to let the temperature go over 225°F and burn (if this happens, you can lose potency). Bake for about 35–40 minutes, then remove from the oven and cool before grinding into a coarse powder. The decarboxylated cannabis will keep in an airtight container in a cool, dark place for up to 2 months 2. Heat the oil in a saucepan over medium-low heat. Add the decarboxylated cannabis and cook, taking care not to let the temperature go over 200°F for about 45 minutes. 3. Remove from heat and let sit, undisturbed, for 10 minutes 4. Strain through a fine mesh-sieve set over a bowl. Press carefully with a spoon to extract as much oil as possible The oil will keep for up to 6 weeks if covered and refrigerated. This recipe is available for download HERE Original recipe from Vice.com [...] Read more...

Cannabis Blueberry Pie Recipe

August 3, 2023Ingredients 6 cups fresh or frozen blueberries (you may substitute some pitted cherries too!) 1 Tbsp lemon juice 1/4 cup all-purpose flour 1/2 cup white sugar (you may add canna-sugar for increased potency) 1/4 tsp cinnamon 2 Tbsp canna-butter, cut into small pieces (you may substitute canna-coconut oil) 2x pie crust recipe or store bought Directions Preheat oven to 350°F/175°C. Line a cookie sheet with parchment paper. Cream the regular butter, cannabutter, brown sugar & white sugar together until fluffy. Beat in eggs one at a time. Beat in the vanilla. In a small bowl, mix together the flour, cinnamon, baking soda & salt. Add to the creamed mixture. Mix well. Add the mini chocolate chips & mini marshmallows. Mix until evenly distributed. Evenly space the graham crackers on the prepared liner. Use a 2 oz scoop to portion the cookies & place in the center of the graham cracker. Bake for 12–15 minutes. Allow the cookies to cool. Push all of the baked cookies together & drizzle with coating chocolate. Allow the chocolate to set & enjoy! This recipe is available for download HERE Original recipe from myedibleschef.com [...] Read more...

Cannabis Caramel Popcorn Recipe

August 3, 2023Ingredients 4 quarts popped popcorn 1 cup brown sugar 1/2 cup corn syrup light 1/2 cup cannabis butter 1/2 tsp salt 1/2 tsp pepper 1 tsp vanilla extract 1/2 tsp baking soda Instructions Preheat your oven to 250 degrees Fahrenheit. Spray a large shallow roasting pan with cooking spray and add popcorn. In a separate bowl mix brown sugar, corn syrup, cannabis butter, and salt in a heavy saucepan. Stirring constantly, bring to a boil over medium heat. Boil 5 minutes without stirring. Remove from heat. Stir in baking soda and vanilla; mix well. Pour syrup over warm popcorn, stirring to coat evenly. Bake for 45 minutes, stirring occasionally. Enjoy! Keep refrigerated for extended shelf life. This recipe is available for download HERE Original recipe from thecannaschool.com [...] Read more...

Cannabis Elevated Instant Ramen Recipe

August 3, 2023Ingredients 1 package of Instant Ramen Vegetable or Beef broth (use the amount listed on the package for water) Frozen vegetable medley One egg or tofu Dried seaweed (to garnish) Sesame Seeds (to garnish) Cannabis Tincture Directions 1. Follow the instructions on the ramen package, but swap the water out for broth 2. Add the frozen veggies when broth gets hot 3. Crack an egg in the hot broth and stir for a few minutes You can also use a hard-boiled egg or chopped tofu 4. Add as much cannabis tincture that you want. If you are unsure, start with 1–2 drops 5. Top soup with dried seaweed and sesame seeds Original recipe from Satori MJ [...] Read more...

Cannabis Meatballs Recipe

August 3, 2023Ingredients 1 cup breadcrumbs 1/2 cup canna-milk 1 lb ground beef 1/2 lb ground pork 1/2 lb Italian sausage, casing removed 1 small onion, finely diced 3 cloves garlic, minced 1 cup grated parmesean cheese 1/4 cup chopped parsley 2 large eggs, beaten 2 Tbsp canna-oil 1 (32oz) jar marinara sauce Instructions 1. In a small bowl, stir bread crumbs with canna-milk until evenly combined. Let sit 15 minutes, or while you prep other ingredients. 2. In a large bowl, use your hands to combine beef, pork, sausage, onion, and garlic. Season with salt and pepper, then gently stir in breadcrumb mixture, eggs, Parmesan, and parsley until just combined. Form mixture into 1” balls. 3. In a large high-sided skillet over medium heat, heat oil. Working in batches, sear meatballs on all sides to develop a crust. Set meatballs aside, reduce heat to medium-low, and add sauce to skillet. Bring sauce to a simmer then immediately add meatballs back to skillet. Cover and simmer until cooked through, about 8 minutes more original recipe from eatyourcannabis.com [...] Read more...

Cannabis S’mores Cookies Recipe

August 3, 2023Ingredients ¼ cup cannabuter, room temperature ½ cup regular butter, room temperature 1 cup brown sugar ½ cup white sugar 2 eggs, room temperature 1 tsp vanilla extract 2 ½ cups all-purpose flour 1 tsp cinnamon ½ tsp baking soda ½ tsp sea salt 1 cup mini chocolate chips 1 cup mini marshmallows 18 graham crackers Coating chocolate, melted Directions Preheat oven to 350°F/175°C. Line a cookie sheet with parchment paper. Cream the regular butter, cannabutter, brown sugar & white sugar together until fluffy. Beat in eggs one at a time. Beat in the vanilla. In a small bowl, mix together the flour, cinnamon, baking soda & salt. Add to the creamed mixture. Mix well. Add the mini chocolate chips & mini marshmallows. Mix until evenly distributed. Evenly space the graham crackers on the prepared liner. Use a 2 oz scoop to portion the cookies & place in the center of the graham cracker. Bake for 12–15 minutes. Allow the cookies to cool. Push all of the baked cookies together & drizzle with coating chocolate. Allow the chocolate to set & enjoy! This recipe is available for download HERE Original recipe from myedibleschef.com [...] Read more...

Cannabis Crab Cakes Recipe

August 3, 2023Ingredients 3 Tbsp mayonnaise 2 Tsp Dijon mustard 1/2 Tsp salt 1/2 Tsp pepper 2 Eggs, lightly beaten 1lb Lump crab meat 2 Tbps finely chopped parsley 3 Tbsp canna-butter Instructions 1. Whisk together mayonnaise, mustard, salt, pepper and eggs. Then gently stir in crab meat, panko and parsley. 2. Shape mixture in to 12 (3-inch) patties, pressing gently to flatten. Cover with plastic wrap and refrigerate for 1hr. 3. Melt half the canna-butter in large, nonstick skillet over medium heat. Add 6 patties to the pan and cook for 2 minutes on each side, or until golden brown. Repeat with the remaining half of canna-butter and remaining 6 patties. The recipe is available for download HERE original recipe from eat your cannabis.com [...] Read more...

Cannabis Garlic and Rosemary Pork Chops Recipe

August 3, 2023Ingredients 4 Pork chops Salt and pepper 1 Tbsp minced rosemary 2 Cloves minced garlic 1/2 Cup canna-butter 1 Tbps canna-oil Instructions 1. Preheat oven to 375°F. Season pork chops with salt and pepper 2. In a small bowl, combine canna-butter with rosemary and garlic. Set aside 3. In an oven-safe skillet over medium heat, heat canna-oil and add pork chops. Sear until golden, about 4 minutes, flip and cook for another 4 minutes. 4. Brush pork-chops generously with the garlic canna-butter mixture and place skillet in the oven to bake for 10–12 minutes. Serve with more garlic butter. If you do not have an oven-safe skillet, you may use a regular one and transfer to a baking dish. Be sure to collect all the oil from the pan when transferring. This recipe is available for download HERE Original recipe from Eat Your Cannabis.com [...] Read more...

Cannabis Quiche Recipe

August 3, 2023This recipe can be used with your favorite vegetables and breakfast meats Ingredients Base: 1 ½ cups of mozzarella cheese, shredded 1/2 cup cheddar cheese, shredded 6 eggs 1 cup of milk (canna-milk may be used for a more potent dish) 1 pie-crust, unbaked Filling: 1/2 cup of canna-butter 1 onion, diced 1 cup broccoli, chopped 1 head of garlic Instructions 1. Melt canna-butter in a pan over medium heat 2. Add vegetables to butter and cook on medium heat for about 5–8 minutes (or until veggies are cooked) Do not let the butter or vegetables burn, to maintain potency of the butter 3. Scoop cooked vegetables into empty pie crust and cover with shredded cheeses 4. Beat eggs and milk together and pour into the pie crust 5. Bake for 35–40 minutes at 360°F Allow quiche to cool 10 minutes before serving This recipe is available for download HERE Original recipe from cannabis.wiki [...] Read more...

Cannabis Sugar Recipe

August 3, 2023Cannabis infused sugar offers a simple way to enhance your baked goods or beverages. Materials Mason Jar Cheesecloth Baking Sheet 9in x 13in Baking Pan Ingredients -3 grams of cannabis flower -1/2 cup of high-proof alcohol, such as Everclear -1/2 cup granulated sugar Directions 1. Decarboxylate the cannabis Heat the oven to 225°F. Spread cannabis buds out into an even layer on a baking sheet and place in the oven. Take care not to let the temperature go over 225°F and burn (if this happens, you can lose potency). Bake for about 35–40 minutes, then remove from the oven and cool before grinding into a coarse powder. The decarboxylated cannabis will keep in an airtight container in a cool, dark place for up to 2 months 2. Transfer the cannabis to a jar and cover with the alcohol. Screw the lid on tight and shake every 5 minutes for 20 minutes. 3. Strain through a cheesecloth set over a bowl, discarding solids. Mix the strained alcohol with the sugar and spread into an even layer in a glass 9-by-13-inch baking dish. 4. Bake at 200°F, stirring occasionally, until the alcohol has evaporated and the sugar is lightly golden. This recipe is available for download HERE The original recipe is from Vice.com [...] Read more...

Cannabis Pancakes Recipe

August 3, 2023Ingredients -1.5 cups all-purpose flour -1 Tbsp sugar (canna-sugar may be substituted to increase potency) -1 Tbsp baking powder -1 Tsp salt -1 large egg -1.25 cups whole milk (canna-milk may be substituted to increase potency) -3 Tbsp of melted canna-butter or oil -1 teaspoon vanilla extract (optional) Instructions 1. In a bowl, combine dry ingredients 2. In another bowl, combine wet ingredients 3. Stir the wet ingredients into the dry ingredients until just combined Do not over-mix, batter will be thick and slightly lumpy 4. Heat a large frying pan with with a small amount of butter or oil 5. Pour 1 cup of batter in the center of the pan. Fry 2–3 minutes before flipping 6. Fry an additional 3–5 minutes or until pancake reaches your preferred doneness and remove from pan 7. Garnish with your favorite toppings; powdered sugar, syrup, butter, chocolate chips or whatever you might enjoy! Original recipe from cannabis wiki [...] Read more...

Cannabis Grilled Cheese Recipe

August 3, 2023Ingredients 2 slices of bread Cheese Canna-Butter Optional fillings: tomato, green onion, chicken, tuna Directions 1. Use a knife to coat both pieces of bread with canna-butter Be sure to coat both sides of the bread 2. Bring skillet to medium heat and add a small scoop of canna-butter 3. One the butter has melted, place one slice of bread on the skillet 4. Add as much cheese and fillings as you like, then place the second slice of bread on top 5. Flip the sandwich when the bottom is golden brown, add more butter if needed for the new side 6. When the sandwich looks adequately fried and the cheese is melted to your liking, take it off of the skillet, slice in half, and enjoy! Original recipe from Satori MJ [...] Read more...

Cannabis Mashed Potatoes Recipe

August 3, 2023Ingredients 2 lbs of potatoes 4 tablespoons cannabutter 4 tablespoons sour cream or plain cream cheese Salt and pepper ¼ to ½ cup of milk or cannamilk for increased potency 2 cloves of garlic minced or 1 tsp of garlic powder Instructions Cut the potatoes in half or quarters to make medium-sized pieces. Place the potatoes in a saucepan filled with water and bring to a boil. Cook until fork-tender, between 20–30 minutes. Drain the potatoes and remove their skins. Add the cannabutter, garlic and sour cream to the bowl along with a splash of milk (don’t add it all at once.) Mash the contents, adding just a splash of milk each time until you’ve reached the desired consistency. Stir in salt and pepper to taste. This recipe is available for download HERE original recipe from satorimj.com [...] Read more...

Cannabis Butter Recipe

August 3, 2023Materials -Medium Sauce-Pan -Thermometer -Mesh-sieve or cheesecloth Ingredients -6 grams cannabis flower -1 pound unsalted butter Directions 1. Decarboxylate the cannabis Heat the oven to 225°F. Spread cannabis buds out into an even layer on a baking sheet and place in the oven. Take care not to let the temperature go over 225°F and burn (if this happens, you can lose potency). Bake for about 35–40 minutes, then remove from the oven and cool before grinding into a coarse powder. The decarboxylated cannabis will keep in an airtight container in a cool, dark place for up to 2 months 2. Heat the butter in a saucepan over medium-low heat. Add the decarboxylated cannabis and cook, taking care not to let the temperature go over 200°F for about 45 minutes. 3. Remove from heat and let sit, undisturbed, for 10 minutes 4. Strain through a fine mesh-sieve set over a bowl. Press carefully with a spoon to extract as much oil as possible The milk will keep for up to 6 weeks if covered and refrigerated. This recipe is available for download HERE Original recipe from Vice.com [...] Read more...