New expert consensus guidelines include evidence-based recommendations for cannabis use disorder treatment alongside other substance dependencies. The British Association for Psychopharmacology guidelines provide clinicians with systematic approaches to pharmacological management while acknowledging current evidence gaps in cannabis dependence treatment.
Acute toxicity of ADB-CHMINACA – a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome.
A new case series reveals that synthetic cannabinoid toxicity emergency treatment protocols are urgently needed as ADB-CHMINACA causes rapid-onset seizures and encephalopathy. Emergency physicians document severe neurologic complications occurring within minutes of synthetic cannabinoid use, highlighting critical safety differences from natural cannabis.
Cannabis modalities matter for momentary subjective drug effects.
A new ecological momentary assessment study reveals that cannabis consumption method subjective effects vary significantly between delivery mechanisms. Researchers found vaporizers produced less subjective intoxication while bongs were associated with greater positive effects compared to other methods in young recreational users.
Cannabis Products and Contaminant Detection: Critical Review of Regulatory Oversight and Analytical Methodologies.
A comprehensive review of cannabis contaminant testing regulatory inconsistencies reveals significant gaps in safety oversight across U.S. jurisdictions. This analysis highlights critical patient safety concerns stemming from variable testing standards for heavy metals, pesticides, and other contaminants. The findings underscore the urgent need for standardized cannabis safety protocols to protect medical and adult-use consumers.
Astrocytic GPR55 receptors promote glycolysis.
The endocannabinoid system is closely associated with systemic and cellular energy metabolism in mammals. We previously demonstrated that the cannabinoid rec…
Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia.
The relationship between the endocannabinoid system and the emergence and treatment of schizophrenia-related symptoms continues to be a topic of significant …
Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics.
While mammalian-derived extracellular vesicles (EVs) face significant challenges in clinical translation due to scalability, cost, and safety, plant-derived …
Polycyclic aromatic hydrocarbons and cannabinoids in secondhand cannabis smoke.
The legalization of cannabis is exposing more people to secondhand smoke (SHS) generated during cannabis use. Given the serious health effects caused by toba…
Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives.
This study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis. This s…
Cannabigerol induces endoplasmic reticulum stress-mediated apoptosis and ferroptosis via the IRE1ฮฑ-XBP1 axis in human pancreatic cancer cells.
Cannabigerol (CBG), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has attracted increasing attention owing to its antibiotic, anti-inflam…