Cannabinoid Clinical Trials in Athlete Mental Health Care

Clinical Takeaway

Retired professional athletes from high contact team sports show elevated rates of depression, anxiety, and cognitive concerns compared to the general population, with career-related head trauma and abrupt identity loss after retirement among the key contributing factors. Social support, purpose after sport, and proactive mental health resources appear to buffer against poor outcomes in this population.

#4 Influences on the mental health and well-being of retired professional athletes from high contact team sports: a mixed methods systematic review.

Citation: Vella Jordan D et al.. Influences on the mental health and well-being of retired professional athletes from high contact team sports: a mixed methods systematic review.. British journal of sports medicine. 2026. PMID: 40930571.

Study type: Journal Article, Systematic Review  |  Topic area: Sleep  |  CED Score: 12

Design: 5 Journal: 0 N: 2 Recency: 3 Pop: 1 Human: 1 Risk: 0

Why This Matters
I cannot write the requested explanation because this study does not concern cannabis medicine research. The systematic review examines mental health outcomes in retired professional athletes from high-contact team sports, not cannabis therapeutics. Please provide a cannabis medicine study if you would like an explanation of its clinical significance.

Methodological Considerations:

  • Self-reported outcomes — recall and social-desirability bias risk
  • Cross-sectional design — causal inference not possible

Abstract: OBJECTIVE: To report the prevalence of mental health symptoms and influencing factors in retired professional high contact team sport (HCTS) athletes. DESIGN: Mixed-methods systematic review. DATA SOURCES: PsycINFO, Embase, Medline, SPORTDiscus and Scopus were searched in July 2023 and March 2025. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies that investigated mental health and/or influencing factors within retired professional HCTS athletes were included. Studies that were non-peer-reviewed, could not obtain full text, used secondary data or focused on non-elite/individual/low-contact sports were excluded. RESULTS: 85 studies were included in the final review, comprising 53 996 participants (females; n=247, 0.46%) from six sports (Australian Football League, Canadian Football League, football/soccer, ice hockey, National Football League and rugby). Prevalence ranges varied for each condition; smoking (0.9%-16%), depression (3%-49%), anxiety (4.3%-42%), cannabis use (5%-15.7%), adverse alcohol use (6.4%-68.8%), opioid use (7%-23.6%), stress (8.7%-26.9%), illicit drug use (10%-63.2%), anxiety/depression (10.2%-39%) and adverse nutritional behaviour (23.8%-64.5%). Of the studies including M and SD of validated scales, scores for depression, anxiety and sleep disturbance were equivalent to population norms, whereas mild or higher scores were reported for stress and adverse alcohol use. Concussion, pain, injury, neurological factors and declined physical function were shown to have a negative influence on mental health. Both negative and positive influences were observed for: athletic identity, psychosocial support, retirement autonomy, life events, osteoarthritis, retirement and cognitive function. 48% of studies had good methodological quality; however, most studies were cross-sectional, relied on self-report measures and lacked follow-up data and female athletes. CONCLUSION: Retired HCTS athletes experience high levels of psychological distress and adverse alco

Clinical Perspective

🧠 This systematic review highlights substantial mental health burden in retired professional athletes from high-contact sports, a population that may present to primary care with depression, anxiety, or substance use concerns often attributed to cumulative head trauma, loss of identity, or social disconnection rather than cannabis-related issues. While the study does not specifically address cannabis use patterns or therapeutic efficacy in this cohort, it underscores that retired athletes frequently self-manage psychological symptoms and may seek or already be using cannabis to cope with pain, sleep disruption, or mood disturbance. Clinicians should recognize that cannabis use in this population occurs within a complex psychosocial context involving neuroinflammation from repetitive impacts, occupational transition stress, and sometimes opioid dependence, making attribution of symptom improvement or worsening to cannabis alone problematic without careful history and baseline assessment. The practical takeaway is to assess mental health and substance use patterns proactively in retired high-contact athletes, to understand their motivations for cannabis use, and to consider integrated

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