✦ New CED Clinical Relevance #70Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. ⚒ Cannabis News | CED Clinic Mental HealthCbdDepressionDrug SafetyDosing Why This MattersThe question of CBD's potential depressive effects reflects a...
Cannabis Meets Drug Metabolism: What We Know—and Don’t Know—About Cannabinoids and CYP450 Enzymes
Recognising potential interactions between cannabinoids and other drugs could enhance understanding of their pharmacological effects, improve the efficacy and safety profiles of cannabinoid-based therapies, and encourage further exploration into this under-researched area of psychopharmacology.
Assessments of Evoked and Spontaneous Pain Following Administration of Gabapentin and the Cannabinoid CB
Cannabinoid CB We compared the impact of LY2828360 on evoked and spontaneous pain in a spared nerve injury (SNI) model using a within-subjects design in rats…
Cannabis and Mental Health: Why ‘Cannabis’ and ‘d9-THC’ Are Not the Same Thing
When headlines report that ‘cannabis’ is detrimental for any number of things, the term is almost exclusively used as a proxy for d9-THC.
Cannabis and Mental Health: It’s Not Just About ‘Cannabis’
It is likely more appropriate to view cannabis use as a contributing factor to a condition with a multifactorial etiology (e.g., genetic predisposition, use of other drugs, familial and social factors), or the result of individuals having a shared vulnerability to psychosis and cannabis use.
Medical Cannabis Evidence Map: Broad Promise, Variable Proof
When considering only high-quality systematic reviews, as evaluated by the AMSTAR 2 tool, 42 out of 67 descriptions of treatment effects for up to 20 health outcomes were classified as ‘Positive’ or ‘Potentially Positive.’ These outcomes included pain, insomnia, seizures, anxiety, muscle spasticity, multiple sclerosis, urinary incontinence, anorexia, and patient safety.
Unveiling Neurological Benefits: A Review of Hemp Leaf, Flower, Seed Oil Extract, and Their Phytochemical Properties in Neurological Disorders.
Neurological disorders such as epilepsy, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis present significant global health care challenges, …
Vaporized cannabis versus placebo for acute migraine: A randomized, double-blind, placebo-controlled crossover trial.
To assess the efficacy of cannabis for the treatment of acute migraine. Preclinical and retrospective studies suggest cannabinoids may be effective in migrai…
Cannabinoids in Pediatric Care: Clinical Evidence Review
Clinical Takeaway Current evidence on cannabinoids in pediatric medicine spans 276 studies across multiple designs, with the strongest data coming from interventional and observational research on plant-derived and pharmaceutical cannabinoid treatments. The...
`Cannabinoid Clinical Trials: CBD and WADA Drug Testing`
Clinical Takeaway Daily use of a broad-spectrum CBD supplement containing trace amounts of other cannabinoids can result in urine concentrations of WADA-prohibited substances such as CBG and CBDV, potentially placing athletes at...