Evaluating Cannabidiol for Pain: Where Clinical Trials Diverge from Hype
medical cannabis research: High-quality randomized clinical trials consistently show pure cannabidiol monotherapy fails to outperform placebo for acute and chronic pain conditions, contrasting sharply with widespread consumer marketing and preclinical…
Adolescent Cannabis Use Alters Brain Reward Pathways and Decision Outcomes
medical cannabis research: Brain imaging reveals that regular cannabis exposure starting before age eighteen blunts striatal responses during reward anticipation while heightening sensitivity to loss. These neurological shifts correlate with measurable…
Cannabis in Pregnancy & Lactation: Endocannabinoid Tone, Placental Transfer & Evidence-Based Abstinence
Oxford CEBM Evidence Level 2A: Clinical Safety & Non-Efficacy Evaluation CED Clinic Medical Counter-Perspective • Evidence-Based Safety Guardrails Direct Clinical Answer & Safety Consensus Cannabis therapy is contraindicated during pregnancy…
Does Rapid Urine Toxicology Screening Help Diagnose Pediatric Coma?
A study in Frontiers in Pediatrics asked whether urinary toxicology rapid screening is a useful first-line diagnostic tool for pediatric coma in the emergency department, including cannabis exposure among the substances tested. Dr. Caplan reviews this…
Cannabinoids & Immunosuppressants & Organ Transplant Therapy: Evidence, Pharmacokinetics & Safety Review
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Real-World Evidence: Geriatric Cannabinoid Pharmacotherapy & Adverse Effect Incidence in Patients Aged 65+
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Cardiovascular Contraindications: Cannabis in Acute Coronary Syndrome, Arrhythmias & Tachycardia
Oxford CEBM Evidence Level 2A: Clinical Safety & Non-Efficacy Evaluation CED Clinic Medical Counter-Perspective • Evidence-Based Safety Guardrails Direct Clinical Answer & Safety Consensus Cannabis is strictly contraindicated during acute…
What Happens After Cannabis Laws Change? A Review of 176 Policy Studies
A systematic review in the Milbank Quarterly pooled 176 quasi-experimental studies examining the impacts of global cannabis policy changes on substance use. Dr. Caplan reviews this cannabis policy change substance use research and what quasi-experimental…
Cannabis Science Full Report: What a Phase 2 CBD Autism Trial Found
A Phase 2 open-label trial in the Journal of Child and Adolescent Psychopharmacology tested cannabidiol for core and associated symptoms of autism in children and adolescents without intellectual disability. Dr. Caplan reviews this CBD autism children…
Real-World Evidence: Cannabinoid Therapy in Patients on Incretin (GLP-1 RA) Weight Management Protocols
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