Clinical Takeaway Standardized diagnostic interviews show variable but generally acceptable test-retest reliability across common adult psychiatric disorders, meaning repeated administrations of the same structured interview do not always produce identical diagnoses. Clinicians...
Why Higher THC Exposure Does Not Necessarily Mean Stronger THC Effects
THC blood levels vs effects is one of the most misunderstood concepts in cannabis medicine. A new study found that CBD increased THC exposure in the bloodstream after vaporized cannabis use. However, higher THC blood concentrations do not automatically translate into greater intoxication, impairment, therapeutic benefit, or clinical effect.
THC and Alzheimer’s Agitation
THC for Alzheimer’s agitation is drawing attention after a randomized placebo-controlled dronabinol trial reported short-term reductions in agitation scores. The study is clinically meaningful because dementia-related agitation can be devastating for patients and caregivers. It does not prove cannabis treats Alzheimer’s disease itself, and full interpretation remains limited by abstract-page access rather than complete full-text review.
SAMHSA’s 2026 Clinical Guidance for Physicians and Patients on Cannabis Use Disorder
SAMHSA released a formal 2026 advisory instructing primary care physicians to evaluate cannabis use based on clinical signs of harm, not simply patient use. Dr. Caplan breaks down what this federal guidance actually says, where current diagnostic tools still fall short, and what patients using medical cannabis should know to protect themselves in clinical settings.
CED Clinical Relevance #7 High Direct Clinical Relevance This controlled human trial directly challenges common assumptions about CBD's appetite effects and has immediate implications for patient counseling about weight changes. 📋...
Cannabis Use in Pregnancy Linked to Child Behavioral Outcomes: A Study on Autism Spectrum Disorder
Clinical Takeaway Prenatal and periconceptional cannabis use is associated with worse behavioral and developmental outcomes in young children, with effects observed across both those with and without autism spectrum disorder symptoms. Children...
Cannabis Induced Psychosis: Systematic Review & Meta-Analysis on Schizophrenia Spectrum & Bipolar Disorder
Clinical Takeaway A significant proportion of people diagnosed with cannabis-induced psychosis go on to develop a primary psychiatric disorder such as schizophrenia or bipolar disorder over time. Clinicians should treat cannabis-induced psychosis...
Cannabinoids for Anxiety & Tourette’s: Evidence from Systematic Reviews and Meta-Analyses in Cannabis Research
Clinical Takeaway Systematic review and meta-analysis evidence suggests that cannabinoid formulations show measurable effects on anxiety-related disorders, though the quality and consistency of that evidence varies across specific conditions and formulations. Clinicians...
Endocannabinoid System Research: Evidence-Based Cannabis Care for Older Adults with Pain, Sleep, and Mental Health Issues
Clinical Takeaway Older adults are increasingly turning to edible cannabis products to manage pain, sleep difficulties, and mental health concerns, with cannabinoid profile playing a key role in product selection. Understanding what...
Cannabidiol Urine Concentrations in Athletes: Effects of Daily Use and Exercise
Clinical Takeaway Athletes using broad-spectrum CBD supplements risk testing positive for WADA-prohibited cannabinoids such as CBG and CBDV, even when the product contains only trace amounts of these compounds. Ten weeks of...