Clinical Takeaway
Cannabinoids modulate pain signaling by affecting sodium channels involved in nerve transmission, based on laboratory evidence from multiple studies. This mechanism may explain part of cannabinoids’ pain-relieving effects, though human clinical outcomes require further study. Current evidence supports sodium channel modulation as one pathway through which cannabinoids influence pain perception.
#18 Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review.
Citation: Castro Samuel Gonçalves et al.. Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review.. Journal of cannabis research. 2026. PMID: 41987259.
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Abstract: Abstract not available.
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