✦ New CED Clinical Relevance #80High Clinical Relevance Strong evidence or policy relevance with direct clinical implications. ⚒ Cannabis News | CED Clinic Pain ManagementMinor CannabinoidsNeuropathic PainCbgPreclinical Research Why This MattersMinor cannabinoids represent an understudied frontier...
GLP-1 Receptor Agonist Clinical Evidence for Weight Loss
GLP-1 Clinical Relevance #44Contextual Information Background context; limited direct clinical applicability. ⚕ GLP-1 News | CED Clinic Clinical TrialPreclinical ResearchPrader-Willi SyndromeGene TherapySemaglutideObesity MedicinePediatric PatientsWeight Loss and Metabolic HealthAppetite Regulation and SatietyGenetic Intervention...
Cannabinoid Pain Relief: Sodium Channel Modulation Research
Clinical Takeaway Cannabinoids modulate pain signaling by affecting sodium channels involved in nerve transmission, based on laboratory evidence from multiple studies. This mechanism may explain part of cannabinoids' pain-relieving effects, though human...
Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion.
Fatty acid-binding protein 7 (FABP7) assists in the intracellular trafficking of endogenous cannabinoids and polyunsaturated fatty acids (PUFAs) and has been…
Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice.
The endocannabinoid system (ECS) and the autophagy receptor p62 are both implicated in metabolic regulation and obesity, yet the mechanisms linking these pat…
Evaluating FABP5 as a Therapeutic Target for Pain Management.
Fatty acid-binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammat…
Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache.
Post-traumatic headache (PTH) is a debilitating neurological sequela of mild traumatic brain injury (mTBI) characterized by secondary cephalic pain. The endo…
Astrocytic GPR55 receptors promote glycolysis.
The endocannabinoid system is closely associated with systemic and cellular energy metabolism in mammals. We previously demonstrated that the cannabinoid rec…
Study: CBN and THCV Effective in Reducing Alcohol Intake, Outperforming CBD
✦ New CED Clinical Relevance #80High Clinical Relevance Strong evidence or policy relevance with direct clinical implications. ⚒ Cannabis News | CED Clinic Addiction MedicineCbnThcvAlcohol Use DisorderPreclinical Research Why This MattersAlcohol use disorder affects millions, and...
The effects of chronic cannabidiol administration on brain pathology and behavioral deficits found in the tau P301s-line PS19 mouse model of Alzheimer’s disease.
BackgroundCompounds derived from the plant