Several in vitro and in vivo studies have shown that cannabinoids can be used to treat various types of cancer; the first positive clinical trials on the anticancer effect of a THC:CBD blend with temozolomide in the treatment of highly invasive brain cancer are very promising.
CB2 Receptors in the Brain: A Promising but Unproven Anti-Inflammatory Target
The activation of CB2 appears to protect the brain and its functions from damage under neuroinflammatory actions, making it an attractive target in a variety of neurological conditions such as Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, and Huntington’s disease.
A novel adverse outcome pathway in aluminum-induced male infertility: Oxidative stress-mediated endoplasmic reticulum stress and endocannabinoid system activation delineated by network toxicology and metabolomics.
Aluminum has been recognized as a reproductive toxin, yet the precise mechanisms by which embryonic exposure impairs male offspring development remain largel…
Activation of Cannabinoid Receptor 1 Enhances Wound Healing by Promoting the Proliferative Phase.
The mechanisms underlying wound healing mediated by cannabinoid receptor 1 (CB1)-known for its neuromodulatory functions-remain incompletely understood. Ther…
Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis.
Cachexia is a debilitating syndrome associated with involuntary weight loss, often occurring in cancer patients. In both humans and animal models, alteration…
Repeated administration of cannabidiol decreases splenic lymphocyte subset numbers in rats.
Cannabidiol (CBD) administration (5 mg/kg) in healthy rats has been shown to significantly decrease lymphocyte subset numbers in peripheral blood without inv…
Therapeutic potential of cannabidiol supplementation in mitigating lipid precursors of inflammation in hepatic steatosis progression.
This study investigated the effects of cannabidiol (CBD) on early-stage inflammation, a key factor in the progression of liver diseases from metabolic dysfun…
Time Course of the Development and Loss of Delta-9-tetrahydrocannabinol Tolerance: Effects on Hypothermia and Spontaneous Locomotor Activity in Mice.
Deregulation of cannabis use is gradually expanding in Europe and the United States. However, the biological processes driving tolerance to delta-9-tetrahydr…
Cannabidiol (CBD) does not reduce cocaine reward or self-administration in a mouse model of schizophrenia genetic susceptibility.
Cannabidiol (CBD) is a non-intoxicating Cannabis sativa plant compound with some preclinical studies reporting efficacy for the treatment of psychiatric diso…
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice.
Anandamide (AEA), an endogenous cannabinoid, is thought to exert an inhibitory role in the basolateral amygdala complex (BLA), dampening hypothalamus-pituita…