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Time Course of THC Tolerance Development and Loss in Mice
This study investigates the THC tolerance development timeline focusing on hypothermia and locomotor activity effects in mice. It reveals rapid tolerance onset and recovery patterns after cessation. Understanding THC tolerance development timeline aids…
Cannabidiol (CBD) Does Not Reduce Cocaine Reward in Schizophrenia Model
CBD schizophrenia substance use effects were tested in a mouse model of genetic susceptibility. The study found no reduction in cocaine reward or self-administration. These findings suggest limited efficacy of CBD for treating substance use in…
Selective Upregulation of FABP5 in Amygdala Reduces Cocaine-Seeking
This study highlights the endocannabinoid system cocaine addiction treatment potential by examining FABP5 upregulation in the basolateral amygdala. Anandamide's role in reducing stress-induced cocaine-seeking behavior is central to this research. These…
Hemp Seed Extract Modulates Metabolic Stress and Autophagy in Cancer Cells
Hemp seed extract anticancer effects involve metabolic stress that reduces ATP and activates AMPK pathways. This extract induces cytostatic effects by arresting cancer cell growth. Autophagy modulation enhances these anticancer effects, offering new…
Potential effects of cannabidiol on formalin-induced inflammatory pain in morphine-dependent rats.
Chronic morphine exposure leads to tolerance and dependence, complicating pain management and reducing the efficacy of opioid analgesics. Cannabidiol (CBD), ...
Therapeutic Effects of a Sesquiterpene-Rich Cannabis Essential Oil on Neuroinflammation
This study highlights the effects of a sesquiterpene-rich essential oil cannabis on neuroinflammation and symptom relief in multiple sclerosis models. The essential oil acts through CB2 receptor pathways to provide neuroprotection. These findings suggest…
Exploring Neuroprotective Effects of Phytocannabinoids in Stroke Models
Phytocannabinoids neuroprotection stroke research explores their potential to reduce neuronal damage in stroke. This study used oxygen-glucose deprived neurons to model stroke conditions. Findings highlight modest neuroprotective effects of certain…
Prenatal cannabis smoke exposure alters placental development in a murine model of pregnancy.
Cannabis use during pregnancy continues to increase with smoking remaining the most common mode of consumption. While clinical studies highlight an associati...
CBD And CBG From Cannabis May Help Treat Liver Condition
CBD CBG preclinical research NAFLD highlights promising cannabis compounds for fatty liver disease. These compounds may reduce liver inflammation and steatosis. This research could advance treatment options for NAFLD patients.
Inhaled CBD Reduces Key Neuroinflammatory Markers in Alzheimer’s Mouse Model
CBD treatment significantly reduced IDO and cGAS expression, correlating with decreased proinflammatory cytokines, including TNF-α, IL-1β, and IFN-γ. These findings support CBD as a potential monotherapy or adjunctive treatment for AD by targeting…