Cannabis for Anxiety, PTSD & Stress: The Biphasic Dilemma | CĒD Clinic
Cannabis for Anxiety, PTSD & Stress: The Biphasic Dilemma Explained
Dr. Benjamin Caplan and Survivor Champion Ethan Zohn explore how cannabinoid receptor mechanics, negative allosteric modulation, and micro-titration regulate stress and fear extinction.
⚡ The Biphasic Inversion Paradox
Cannabinoids exhibit opposite neurochemical effects depending on dose. Low doses activate anxiolytic calming pathways, whereas excessive THC overstimulates CB1 receptors in the amygdala, precipitating acute panic and paranoia.
🛡️ CBD as a Protective Buffer
Cannabidiol (CBD) acts as a negative allosteric modulator of CB1 receptors. By physically altering the receptor’s conformation, CBD dampens THC’s psychoactive intensity while preserving somatic relaxation.
🌸 Anxiolytic Terpenes (Linalool & Limonene)
Beyond cannabinoids, lavender-scented linalool enhances GABAergic neurotransmission, while citrus-scented limonene facilitates serotonin release, forming an organic entourage for trauma recovery.
60-Second Anxiety, Panic & PTSD Reset Reels
Dr. Caplan explains the neurobiology of fear extinction, the biphasic curve, and surviving acute THC overconsumption.
