The endocannabinoid system, which comprises signaling lipid molecules classified as endocannabinoids and the receptors that they bind to, is widely expressed throughout all organs of the human body. This system plays a...
The role of cannabinoids in dermatology
Historically, medical cannabis has been used most extensively to treat chronic pain, anorexia, and nausea in advanced cancer patients undergoing chemotherapy. Recently, its therapeutic effects against many other conditions have been actively...
Cannabidiol Acts at 5-HT1A Receptors in the Human Brain: Relevance for Treating Temporal Lobe Epilepsy
Epilepsy is a very common disorder characterized by recurrent, spontaneous seizures, and a seizure is induced by the abnormal, synchronous excitation of neurons in the brain. Gi/o proteins inside neurons, when activated,...
Safety and Tolerability of Cannabidiol in Parkinson Disease: An Open Label, Dose-Escalation Study
Parkinson disease (PD) is a neurodegenerative disorder very common among the older population. Since standard treatments often only partially relieve symptoms, many patients turn to complementary and alternative medication such as cannabis....
Acute effects of partial CB1 receptor agonists on cognition – A meta-analysis of human studies
In Summary: Cannabis is one of the most widely consumed psychoactive plants in the world, and THC is the main component responsible for cannabis’ psychological effects - namely the sense of relaxation...
Cannabis Improves Obsessive-Compulsive Disorder—Case Report and Review of the Literature
In Summary: Obsessive-compulsive disorder (OCD) is a severe and underdiagnosed mental disorder that causes substantial impairments in most patients’ quality of life. It is characterized by the presence of obsessions - which...
Topical cannabis-based medicines – A novel, effective treatment for non-uremic calciphylaxis leg ulcers
Topical cannabis-based medicines – A novel paradigm and treatment for non-uremic/ calciphylaxis leg ulcers: An open label trial In Summary: Non-Uremic Calciphylaxis (NUC) is a rare condition that manifests as painful, non-healing...
Targeting the cannabinoid receptors to regulate blood glucose level and body weight
Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice In Summary The pancreas is the organ that produces insulin and its lesser known counterpart, glucagon, both of...
Is Cannabis a Valid Treatment for Coronavirus?
Researchers Looking At CBD To Treat COVID-19 Lung Inflammation In Summary As more information comes to light about the severe lung inflammation that seems to be the most dangerous symptom of this...
The Relationship Between Cannabis and Nicotine may Reveal Novel Treatments
Acute separate and combined effects of cannabinoid and nicotinic receptor agonists on MMN-indexed auditory deviance detection in healthy humans In Summary Researchers have attempted to elucidate the relationship between nicotine and cannabis...