Cannabidiol has well described drug interactions including inhibition of clobazam metabolism. Phenytoin is known to induce metabolism of cannabidiol. Cannabi…
Tuberculous Peripancreatic Lymphadenitis Presenting as Obstructive Jaundice Due to Extrinsic Common Bile Duct Compression: A Case Report.
We report the case of a 29-year-old maleย from the Indian subcontinent (a tuberculosis (TB)-endemic region) residing in Qatar, who presented with a three-day …
Circuit-Selective FAAH Inhibition Suppresses Experimental Absence Seizures.
Childhood absence epilepsy (CAE) arises from dysfunctional corticothalamic networks generating spike wave discharges (SWDs) and behavioral arrest. Despite av…
Cannabidiol and diabetic heart disease: Mechanistic evidence and translational challenges.
Diabetic heart disease (DHD) is a major contributor to global cardiovascular morbidity, driven by a complex interplay of metabolic, inflammatory, oxidative, …
Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache.
Post-traumatic headache (PTH) is a debilitating neurological sequela of mild traumatic brain injury (mTBI) characterized by secondary cephalic pain. The endo…
Astrocytic GPR55 receptors promote glycolysis.
The endocannabinoid system is closely associated with systemic and cellular energy metabolism in mammals. We previously demonstrated that the cannabinoid rec…
Anti-inflammatory effects of Glehnia littoralis ethyl acetate extract and its active compound phellopterin via inhibition of N-acylethanolamine acid amidase.
In East Asia, the root of Glehnia littoralis (J.G.Cooper) F.Schmidt ex Miq. is traditionally used to relieve “yin-deficiency lung dryness,” nourishing yin, m…
Targeting CB1 and TRPM8 receptors to counteract CD8+ T cell exhaustion.
The prolonged interaction between the immune system and tumor antigens can result in T cell exhaustion. Extensive research has been conducted on strategies t…
Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People With Multiple Sclerosis.
To examine daily within-person associations between symptoms reported by people with multiple sclerosis (MS) and psychoactive substance use using ecological …