The ways cannabis is consumed, or modes of use, have increased and diversified in recent years, especially among young people. Associations of multimodal can…
Medically Recommended Cannabis Use for US Adolescents.
As more states legalize medical cannabis, there is growing interest in its use in adolescents. This nationally-representative study assesses the prevalence o…
Implementation of a Standardized Management Algorithm for Cannabis Hyperemesis Syndrome in a Pediatric Emergency Department.
Cannabis hyperemesis syndrome (CHS) is an increasingly common cause of pediatric emergency department (ED) visits, yet management pathways remain understudie…
The role of cannabinoid ligands in neurodegenerative diseases: emerging anti-inflammatory, immunomodulation and disease-modifying perspectives.
Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies. Althoug…
Analytical Challenges and Emerging Detection Strategies of Synthetic Cannabinoids in Horse Doping Control.
Synthetic cannabinoids (SCs) were originally synthesized to advance the understanding of the endocannabinoid system, facilitate disease research, and support…
Aryl-Cyclohexanone as a Potential CB2 Agonist: In Vitro and In Silico Evidence in Inflammatory Modulation.
Inflammation is an evolutionarily conserved adaptive process essential for host defense against harmful stimuli, aimed at restoring homeostasis. However, exa…
Targeting CB1 and TRPM8 receptors to counteract CD8+ T cell exhaustion.
The prolonged interaction between the immune system and tumor antigens can result in T cell exhaustion. Extensive research has been conducted on strategies t…
Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice.
The endocannabinoid system (ECS) and the autophagy receptor p62 are both implicated in metabolic regulation and obesity, yet the mechanisms linking these pat…
Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion.
Fatty acid-binding protein 7 (FABP7) assists in the intracellular trafficking of endogenous cannabinoids and polyunsaturated fatty acids (PUFAs) and has been…
Investigating the Synergistic Effect of the Cannabis Extract PHEC-66 and Chemotherapeutic Agents on Human Melanoma Cells.
Melanoma is a malignant neoplasm that originates from melanocytes. It continues to pose a significant challenge in oncology due to its aggressive nature and …