Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.

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China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population. Based on summary statistics of existing genome-wide association studies in East Asian ancestry (EAS) and European ancestry (EUR) populations, we tested the associations of polygenic scores (PGSs) for schizophrenia (SCZ) and major depression (MD) with 254 phenotypes in 100,640 Chinese adults. We also conducted genetic correlation and Mendelian randomization analyses to assess the consistency of these associations across ancestries and infer causality. The PGSs predicted SCZ ( Our study suggests the context specificity of relationships between mental disorders and other traits, highlighting a potential role of sociocultural factors. The presentation of mental disorders in China can be distinct from that in other populations. Here, we calculated scores that indicate an individual’s genetic risk for schizophrenia and depression for ∼100,000 Chines

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