| Journal | Biological psychiatry global open science |
| Study Type | Clinical Study |
| Population | Human participants |
This item covers developments relevant to cannabis medicine and clinical practice. Clinicians monitoring evidence in this area should review the source material.
China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population. Based on summary statistics of existing genome-wide association studies in East Asian ancestry (EAS) and European ancestry (EUR) populations, we tested the associations of polygenic scores (PGSs) for schizophrenia (SCZ) and major depression (MD) with 254 phenotypes in 100,640 Chinese adults. We also conducted genetic correlation and Mendelian randomization analyses to assess the consistency of these associations across ancestries and infer causality. The PGSs predicted SCZ ( Our study suggests the context specificity of relationships between mental disorders and other traits, highlighting a potential role of sociocultural factors. The presentation of mental disorders in China can be distinct from that in other populations. Here, we calculated scores that indicate an individual’s genetic risk for schizophrenia and depression for ∼100,000 Chines
“This is a development worth tracking. The clinical implications will become clearer as more evidence accumulates.”
💬 Join the Conversation
Have a question about how this applies to your situation? Ask Dr. Caplan →
Want to discuss this topic with other patients and caregivers? Join the forum discussion →
Have thoughts on this? Share it:
FAQ
This study item was assembled from normalized source metadata and pipeline scoring.
