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      • ❤️ Our Core Values: The Heart of CED Clinic
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      • 🎟️ Lottery for a Free Consultation
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    • ⚕️ Patient Care (Adults, Pediatrics)
      • 🧠 Health Quiz: How’s Your Health?
      • 🩺 New Patients - Welcome!
        • 🪪 How to Get a Medical Marijuana Card (in MA)
        • ⭐ Testimonials
        • 🗣️ Patient Stories
        • 📅 Book An Appointment
        • 🧑‍⚕️ Adult Cannabis Care
        • 🧩 Autism, Behavior & Language Help
        • 💻 Request a Virtual Visit
      • 🌿 Before & After Apppointments
        • ❓ Qualifying Conditions
        • 👀 Ailments That Cannabis Treats
        • 📅 Book a Virtual Appointment
        • 🚀 Your Cannabis Journey
        • 🏥 Your First Visit
        • 📝 Registration Information
        • 🫂 Caregiver Information
        • ➡️ After Registration
        • ⚖️ Which Products Are For You?
      • 🖤 Cannabis & Seniors
        • 👩‍🦳 Seniors & Healthy Aging
        • 👩‍🦳 Cannabis & Seniors: A New Chapter in Comfort
        • 💜 🎗 Cancer & Terminal Illness Support
        • 🕊 End-of-Life Planning
        • Blog: Rising Cannabis Use in Older Adults
      • 😎 Pediatrics & Adolescents
        • 👶 5 Benefits of Pediatric Cannabis Certification
        • 🥳 Pediatric & Adolescent Care
        • 😱 10 Ways Cannabis Supports Children’s Behavior
        • 🆘 Children & Behavior Support
        • 💧 Safe Dosing for Kids
      • 🤖 Help + Answers - by Chatbot!
      • 💰 Discounts at CED
        • 🏪 Discounts at Dispensaries (MA)
        • 💪 Labor Day Sale
        • 😍 Discounts, Coupons, and Free Consultations
    • 📚 Education
      • 🖐️ Practical Tips + Guidance
        • 🧳 Travel With Cannabis
        • 🧪 COA Guide & Lab Safety
        • 🛠 Fixing Your Cannabis Tolerance
        • 🧑‍🏫 Why Cannabis Works
        • 🤏 Smart Cannabis Dosing: Sweet Spot?
        • 🧐 Cannabis Myths + Blind Spots
        • 😷 How to Talk to Your Doc about Cannabis
        • 🌿 Slow Medicine: How Cannabis Heals Over Time
        • 🚨 Why The War on Pot Rages
        • ⚠️ Feeling Too High?
        • 🧠 Cannabis & Mental Health Truths
        • 🫁 Cannabis Cough: The Basics
        • 🌬️ Science of The Cannabis Cough
        • 📛 What To Do: Feeling Too Racy
        • 😱 Weed Anxiety Explained: Paranoia, Panic & Relief
        • 🍉 Why Aren’t Edibles Don't Work for You?
        • ⛔ When to Pause
        • 🤮 Cannabis Hyperemesis Syndrome (CHS): What to Know
      • ❤️‍🩹 Health & Wellness
        • 🩺 Cannabis & Health (general)
        • 🤓 Choosing Cannabis
        • 🦾 Tips for Maximizing Effectiveness
        • ⚡ Cannabis & Metabolism: Be Amazed!
        • 🌙 Cannabis for Sleep
        • 😌 Cannabis for Stress
        • 💊 Cannabis for Pain
        • 💪 Topicals Guide
        • 🔭 Future of Cannabis
      • 🚨 Learn by Illness or Condition
        • 🎯 Custom Cannabis Protocol
        • 🧠 Mental Health & Neurological Disorders
        • 🎯 ADHD: A Guide to Focus, Calm, and Control
        • 🧬 Crohn’s and Gut Health: Relief Strategies
        • 🫀 Gastrointestinal & Autoimmune Conditions
        • 🦠 Dermatological & Skin Conditions
        • 🔥 Chronic Pain & Inflammation
        • 💖 Women’s Health & Hormonal Conditions
        • 👨‍👧 Pregnancy & Cannabis, Explained
        • 🌙 Sleep Disorders & Circadian Rhythm Issues
        • ⚠️ Pain Management with Cannabis
        • 🧩 Autism & Behavior: Expert Guidance for Families
        • 🪡 Post-Surgical & Injury Recovery
        • 🍾 Substance Dependence & Withdrawal Support
      • 🥦 Learn about Products
        • 🌿 Types of Cannabis Sold
        • 🌿 CBD Strength Guide
        • 📉🌿 Cannabis Tolerance: Management
        • 🛁 Topical Cannabis Products: Guide to Uses, Benefits & DIY
        • 🧬 Unique Cannabinoids: Beyond THC & CBD
        • 💨 Vaporizing Cannabis: Safer, Effective Consumption
        • 📓 Outside Resources
      • 🔎 Best Ways To Take Cannabis
        • ❓ Cannabis FAQs (basic)
        • 🌱 Start Here
        • 🧩 Cannabis Therapy Guidance
        • ⏲︎ Dosage & Usage Guide
        • 💨 Nebulized Cannabis Guide
        • 🧴 Topicals & Lotions
        • 🩸 Tinctures & Oils
        • 🍭 Cannabis Edibles & Capsules
        • 💨 Inhalables & Vaporization
      • 🏚️ Educational Resources
        • 📰 CED Clinic Blog
        • 🗞️ Dr Caplan's Newsletter
        • 🧐 FAQ Encyclopedia
        • 🩺 Dr Caplan's Classroom
          • 📕 The Doctor-Approved Cannabis Handbook (Book site)
          • 📰 CED Blog
          • 🤖 Cannabis AI (CAI)
          • 🧑‍🎓 Book Diagrams + CaplanCannabis Site (free)
          • 🎥 Video Library
          • 📝 Handouts & Guides
          • 🤖 AI Book Review
          • 🎙️ Spotify: Green Table Talk Podcast
          • ▶️ YouTube
          • 🛒 Dr Caplan's Book (Order Now - Amazon!)
        • 🌱 Cannabis Basics Overview
        • 🧠 The Problems Cannabis Helps Us Manage
        • 🧠 Endocannabinoid System
        • 🔬 Cannabis Science
        • 📖 CED Cannabis Literature Library
        • 📊 Patient Care & Findings
        • 📈 Patient Insights
      • 🤖 AI Chatbot Cannabis Librarian: CAI
    • 🧳 Partner with Dr Caplan
      • 📚 Partner on Education & Research
      • 👔 Work with Dr Caplan
      • 📢 Media Inquiries
      • 🗨️ Interview Dr. Caplan
      • 🎤 Book Dr. Caplan to Speak
      • 🎓 Clinical Cannabis Education Program
      • 🧠 Modular (Custom) Professional Education
      • 💼 Volunteer @ CED: 📱 Join The Social Impact Squad
      • 📊 Cannabis Business Consulting
      • 🛠️ Building Big Data
    • 🙏 Community | Socials | Connect
      • 📞 Connect
        • 💬 Leave a Message
        • 📩 Email CED Clinic
        • ⚡ Quick Visit Request
        • 📖 Share Your Story
        • 💬 Discussion Forums
        • ⚕️ Ask Dr Caplan (public Q&A)
      • 🔗 Resources & Events
        • 🏛️ Dispensary Highlights
        • 🤞 Upcoming Events
        • 🤘 Past Events
        • 🔥 Fireside Chats
      • 🫱🏼‍🫲🏾 All of Dr Caplan's socials
      • 📝 Dr Caplan's "top 100" Newsletter
      • 🧠 Dr Caplan: X / Twitter
      • 🖼️ Dr Caplan: Instagram
      • 📣 Dr Caplan: Podcast
      • 📺 Dr Caplan: YouTube
    • ⚠️ What's New
      • 📩 Dr Caplan's "top 100" Substack)
      • 🧐 FAQ (Cannabis Encyclopedia)
      • ✍️ Non-Cannabis Writing
        • 🔘 Power of Clicks and Likes
        • ❤️‍🩹 Rethinking Diagnosis in Kids
      • 💚 Favorites: July 2025
        • 🔁 Reset Your Cannabis Tolerance
        • 😱 Weed Anxiety Explained: A Doctor’s Guide to Paranoia, Panic & Relief
        • 🧴 5 Reasons CBD CBG Topicals For Eczema Care is Amazing
        • 🌘 Cannabis for Sleep
        • 🌿 Slow Medicine: How Cannabis Heals Over Time
        • 🍉 Why Aren’t Edibles Working for You?
        • ⛔ When Cannabis Might NOT Be Right for You
        • 💓 Women’s Health & Hormonal Conditions
        • 😟 Cannabis for Stress
        • 🎯 Cannabis for ADHD: A Guide to Focus, Calm, and Control
        • ⚠️ Too High? What To Do
        • 🤮 Moldy Marijuana: MA recalls moldy flower
      • 🌿 High-Potency Cannabis Guide
      • 🌼 Light THC & CBD Picks
      • 🍃 Sugar-Free Cannabis Options
      • 🌸 Vaginal Suppositories Page
      • 🍑 Rectal Suppositories Page
      • 💡 Video: Cannabis Tolerance Explained
      • 💓 Blog: Cannabis & Your Heart
      • 😱 Blog: Cannabis and Psychosis
      • 🛟 Blog: Long-Term Effects of Cannabis
      • 🩵 Blog: Cannabis and Heart Health
      • 🌿 Blog: Is Weed Addictive? Dependence vs Addiction
      • 🙅‍♀️ Blog: Cannabis and Menopause
      • 🧪 Blog: CBD & Liver Enzymes
    • 🧑‍🍳 Cannabis Recipes
      • 🍫 Cannabis-Infused Chocolate Sauce (Easy Edible Recipe)
      • 🍯 How to Make Cannabis-Infused Honey | Easy DIY Edible, Dosing & Benefits
      • 🥜 Cannabis-Infused Peanut Butter Recipe | Easy Edibles Guide
      • 🥪 Cannabis Grilled Cheese Recipe
      • 🧇 Cannabis Waffles Recipe
      • 🍲 Cannabis Mashed Potatoes Recipe
      • 👩‍🍳 All The Recipes
    • 📝 CED Blog
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  • Page 27
CED Clinic Blog

Blunted highs: Cannabis tolerance behavioral models and pharmacodynamics

Chronic daily cannabis use builds tolerance to some but not all of the effects of cannabis With the increase of...

Read More
CED Clinic Blog

The roles of THC and CB1 receptors in cannabis reinforcement and dependence

Cannabis reinforcement and dependence occur through cannabinoid type 1 receptors Cannabis is the most commonly used drug worldwide, and chronic...

Read More
CED Clinic Blog

Illicit drug use: Dependence and contributions to the global burden of disease

In 2009, an estimated 149–271 million people worldwide used illicit drugs. 125–203 million were cannabis users. These numbers likely undercount...

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CED Clinic Blog

Endocannabinoids and stress: Effects of indirect agonists and comparison of male and female mice

Cannabis has stress reducing effects in females as well as males The potential of cannabinoids to treat stress and anxiety...

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CED Clinic Blog

Is cannabis an antibiotic savior in antibiotic-induced bacteremia?

​New research shows that cannabis use is linked to decreased incidence of Clostridioides difficile infection Clostridioides difficile infection (CDI) linked...

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CED Clinic Blog

Do sex and steroid hormones affect cannabis outcomes? A review of the endocannabinoid system

Sex hormones (estrogen, progesterone, and testosterone) substantially impact sexual differentiation, maturation, and adult sexual behavior. The effect of poorly regulated...

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CED Clinic Blog

Cannabis Interactions with Drugs and Clinical Considerations

Cannabis Interactions with Drugs and Clinical Considerations Cannabis use has become more prevalent in recent years. With increasing legalization of...

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Categories

  • Cannabis Memes
  • Cannabis News
  • Cannabis Recipes
  • CED Clinic Blog
  • Featured Partners
  • Site Map

Dr Caplan's Newsletter 👇

Latest posts

  • DOJ accuses 2 people of selling gun to Trump’s alleged would-be assassin Ryan Routh
  • Camp Mystic disaster plan approved days before Central Texas flood
  • 7/8: The Takeout with Major Garrett
  • 7/8: The Daily Report
  • Deadly New Mexico flash flooding prompts dozens of rescues, sweeps house away

Latest post

  • DOJ accuses 2 people of selling gun to Trump’s alleged would-be assassin Ryan Routh
  • Camp Mystic disaster plan approved days before Central Texas flood
  • 7/8: The Takeout with Major Garrett
  • 7/8: The Daily Report
  • Deadly New Mexico flash flooding prompts dozens of rescues, sweeps house away

Post Categories

  • Cannabis Memes
  • Cannabis News
  • Cannabis Recipes
  • CED Clinic Blog
  • Featured Partners

Read the latest in cannabis science: Dr Caplan's Newsletter (click here)

    • 📍 Home
    • ℹ️ About
      • 👨‍⚕️ Meet Dr. Caplan
        • 📗 Cannabis Handbook
      • 👩‍⚕️ Meet Erin Caplan, NP
      • ❤️ Our Core Values: The Heart of CED Clinic
      • 📖 Learn More: CED Clinic
      • 🎟️ Lottery for a Free Consultation
      • 🎁 Sponsor a Visit (Give a Gift of Care)
      • 🗺️ SiteMap
    • ⚕️ Patient Care (Adults, Pediatrics)
      • 🧠 Health Quiz: How’s Your Health?
      • 🩺 New Patients - Welcome!
        • 🪪 How to Get a Medical Marijuana Card (in MA)
        • ⭐ Testimonials
        • 🗣️ Patient Stories
        • 📅 Book An Appointment
        • 🧑‍⚕️ Adult Cannabis Care
        • 🧩 Autism, Behavior & Language Help
        • 💻 Request a Virtual Visit
      • 🌿 Before & After Apppointments
        • ❓ Qualifying Conditions
        • 👀 Ailments That Cannabis Treats
        • 📅 Book a Virtual Appointment
        • 🚀 Your Cannabis Journey
        • 🏥 Your First Visit
        • 📝 Registration Information
        • 🫂 Caregiver Information
        • ➡️ After Registration
        • ⚖️ Which Products Are For You?
      • 🖤 Cannabis & Seniors
        • 👩‍🦳 Seniors & Healthy Aging
        • 👩‍🦳 Cannabis & Seniors: A New Chapter in Comfort
        • 💜 🎗 Cancer & Terminal Illness Support
        • 🕊 End-of-Life Planning
        • Blog: Rising Cannabis Use in Older Adults
      • 😎 Pediatrics & Adolescents
        • 👶 5 Benefits of Pediatric Cannabis Certification
        • 🥳 Pediatric & Adolescent Care
        • 😱 10 Ways Cannabis Supports Children’s Behavior
        • 🆘 Children & Behavior Support
        • 💧 Safe Dosing for Kids
      • 🤖 Help + Answers - by Chatbot!
      • 💰 Discounts at CED
        • 🏪 Discounts at Dispensaries (MA)
        • 💪 Labor Day Sale
        • 😍 Discounts, Coupons, and Free Consultations
    • 📚 Education
      • 🖐️ Practical Tips + Guidance
        • 🧳 Travel With Cannabis
        • 🧪 COA Guide & Lab Safety
        • 🛠 Fixing Your Cannabis Tolerance
        • 🧑‍🏫 Why Cannabis Works
        • 🤏 Smart Cannabis Dosing: Sweet Spot?
        • 🧐 Cannabis Myths + Blind Spots
        • 😷 How to Talk to Your Doc about Cannabis
        • 🌿 Slow Medicine: How Cannabis Heals Over Time
        • 🚨 Why The War on Pot Rages
        • ⚠️ Feeling Too High?
        • 🧠 Cannabis & Mental Health Truths
        • 🫁 Cannabis Cough: The Basics
        • 🌬️ Science of The Cannabis Cough
        • 📛 What To Do: Feeling Too Racy
        • 😱 Weed Anxiety Explained: Paranoia, Panic & Relief
        • 🍉 Why Aren’t Edibles Don't Work for You?
        • ⛔ When to Pause
        • 🤮 Cannabis Hyperemesis Syndrome (CHS): What to Know
      • ❤️‍🩹 Health & Wellness
        • 🩺 Cannabis & Health (general)
        • 🤓 Choosing Cannabis
        • 🦾 Tips for Maximizing Effectiveness
        • ⚡ Cannabis & Metabolism: Be Amazed!
        • 🌙 Cannabis for Sleep
        • 😌 Cannabis for Stress
        • 💊 Cannabis for Pain
        • 💪 Topicals Guide
        • 🔭 Future of Cannabis
      • 🚨 Learn by Illness or Condition
        • 🎯 Custom Cannabis Protocol
        • 🧠 Mental Health & Neurological Disorders
        • 🎯 ADHD: A Guide to Focus, Calm, and Control
        • 🧬 Crohn’s and Gut Health: Relief Strategies
        • 🫀 Gastrointestinal & Autoimmune Conditions
        • 🦠 Dermatological & Skin Conditions
        • 🔥 Chronic Pain & Inflammation
        • 💖 Women’s Health & Hormonal Conditions
        • 👨‍👧 Pregnancy & Cannabis, Explained
        • 🌙 Sleep Disorders & Circadian Rhythm Issues
        • ⚠️ Pain Management with Cannabis
        • 🧩 Autism & Behavior: Expert Guidance for Families
        • 🪡 Post-Surgical & Injury Recovery
        • 🍾 Substance Dependence & Withdrawal Support
      • 🥦 Learn about Products
        • 🌿 Types of Cannabis Sold
        • 🌿 CBD Strength Guide
        • 📉🌿 Cannabis Tolerance: Management
        • 🛁 Topical Cannabis Products: Guide to Uses, Benefits & DIY
        • 🧬 Unique Cannabinoids: Beyond THC & CBD
        • 💨 Vaporizing Cannabis: Safer, Effective Consumption
        • 📓 Outside Resources
      • 🔎 Best Ways To Take Cannabis
        • ❓ Cannabis FAQs (basic)
        • 🌱 Start Here
        • 🧩 Cannabis Therapy Guidance
        • ⏲︎ Dosage & Usage Guide
        • 💨 Nebulized Cannabis Guide
        • 🧴 Topicals & Lotions
        • 🩸 Tinctures & Oils
        • 🍭 Cannabis Edibles & Capsules
        • 💨 Inhalables & Vaporization
      • 🏚️ Educational Resources
        • 📰 CED Clinic Blog
        • 🗞️ Dr Caplan's Newsletter
        • 🧐 FAQ Encyclopedia
        • 🩺 Dr Caplan's Classroom
          • 📕 The Doctor-Approved Cannabis Handbook (Book site)
          • 📰 CED Blog
          • 🤖 Cannabis AI (CAI)
          • 🧑‍🎓 Book Diagrams + CaplanCannabis Site (free)
          • 🎥 Video Library
          • 📝 Handouts & Guides
          • 🤖 AI Book Review
          • 🎙️ Spotify: Green Table Talk Podcast
          • ▶️ YouTube
          • 🛒 Dr Caplan's Book (Order Now - Amazon!)
        • 🌱 Cannabis Basics Overview
        • 🧠 The Problems Cannabis Helps Us Manage
        • 🧠 Endocannabinoid System
        • 🔬 Cannabis Science
        • 📖 CED Cannabis Literature Library
        • 📊 Patient Care & Findings
        • 📈 Patient Insights
      • 🤖 AI Chatbot Cannabis Librarian: CAI
    • 🧳 Partner with Dr Caplan
      • 📚 Partner on Education & Research
      • 👔 Work with Dr Caplan
      • 📢 Media Inquiries
      • 🗨️ Interview Dr. Caplan
      • 🎤 Book Dr. Caplan to Speak
      • 🎓 Clinical Cannabis Education Program
      • 🧠 Modular (Custom) Professional Education
      • 💼 Volunteer @ CED: 📱 Join The Social Impact Squad
      • 📊 Cannabis Business Consulting
      • 🛠️ Building Big Data
    • 🙏 Community | Socials | Connect
      • 📞 Connect
        • 💬 Leave a Message
        • 📩 Email CED Clinic
        • ⚡ Quick Visit Request
        • 📖 Share Your Story
        • 💬 Discussion Forums
        • ⚕️ Ask Dr Caplan (public Q&A)
      • 🔗 Resources & Events
        • 🏛️ Dispensary Highlights
        • 🤞 Upcoming Events
        • 🤘 Past Events
        • 🔥 Fireside Chats
      • 🫱🏼‍🫲🏾 All of Dr Caplan's socials
      • 📝 Dr Caplan's "top 100" Newsletter
      • 🧠 Dr Caplan: X / Twitter
      • 🖼️ Dr Caplan: Instagram
      • 📣 Dr Caplan: Podcast
      • 📺 Dr Caplan: YouTube
    • ⚠️ What's New
      • 📩 Dr Caplan's "top 100" Substack)
      • 🧐 FAQ (Cannabis Encyclopedia)
      • ✍️ Non-Cannabis Writing
        • 🔘 Power of Clicks and Likes
        • ❤️‍🩹 Rethinking Diagnosis in Kids
      • 💚 Favorites: July 2025
        • 🔁 Reset Your Cannabis Tolerance
        • 😱 Weed Anxiety Explained: A Doctor’s Guide to Paranoia, Panic & Relief
        • 🧴 5 Reasons CBD CBG Topicals For Eczema Care is Amazing
        • 🌘 Cannabis for Sleep
        • 🌿 Slow Medicine: How Cannabis Heals Over Time
        • 🍉 Why Aren’t Edibles Working for You?
        • ⛔ When Cannabis Might NOT Be Right for You
        • 💓 Women’s Health & Hormonal Conditions
        • 😟 Cannabis for Stress
        • 🎯 Cannabis for ADHD: A Guide to Focus, Calm, and Control
        • ⚠️ Too High? What To Do
        • 🤮 Moldy Marijuana: MA recalls moldy flower
      • 🌿 High-Potency Cannabis Guide
      • 🌼 Light THC & CBD Picks
      • 🍃 Sugar-Free Cannabis Options
      • 🌸 Vaginal Suppositories Page
      • 🍑 Rectal Suppositories Page
      • 💡 Video: Cannabis Tolerance Explained
      • 💓 Blog: Cannabis & Your Heart
      • 😱 Blog: Cannabis and Psychosis
      • 🛟 Blog: Long-Term Effects of Cannabis
      • 🩵 Blog: Cannabis and Heart Health
      • 🌿 Blog: Is Weed Addictive? Dependence vs Addiction
      • 🙅‍♀️ Blog: Cannabis and Menopause
      • 🧪 Blog: CBD & Liver Enzymes
    • 🧑‍🍳 Cannabis Recipes
      • 🍫 Cannabis-Infused Chocolate Sauce (Easy Edible Recipe)
      • 🍯 How to Make Cannabis-Infused Honey | Easy DIY Edible, Dosing & Benefits
      • 🥜 Cannabis-Infused Peanut Butter Recipe | Easy Edibles Guide
      • 🥪 Cannabis Grilled Cheese Recipe
      • 🧇 Cannabis Waffles Recipe
      • 🍲 Cannabis Mashed Potatoes Recipe
      • 👩‍🍳 All The Recipes
    • 📝 CED Blog

Contact Info

Address:

163 Highland Ave, #1035, Needham, MA 02494

Email:

info@cedclinic.com

Phone:

617-500-3595

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