The endogenous cannabinoid system is a signaling system of the human body that comprises endocannabinoids (such as anandamide and 2-AG), cell-surface receptors (CB1 and CB2), as well as proteins responsible for the...
Anti-invasion Effects of Cannabinoids Agonist and Antagonist on Human Breast Cancer Stem Cells
In most types of solid tumors, the metastasis of invasive tumor cells from their origin to different organs throughout the body is often lethal to patients. Recent research has uncovered the crucial...
The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers
Tobacco smoking is a leading cause of preventable death, yet only one-third of those who try can successfully quit smoking. This highlights the current lack of effective treatment options for nicotine dependence....
Using measured cannabidiol and tetrahydrocannabinol metabolites in urine to differentiate marijuana use from consumption of commercial cannabidiol products
The current method for detection of marijuana use measures 11-nor-carboxy-ฮ9-tetrahydrocannabinol (11-COOH-THC), the major metabolite of THC in a personโs urine. However, commercially available CBD products sold without purity regulations often contain trace...
The proposed mechanisms of action of CBD in epilepsy
Cannabidiol (CBD) has demonstrated positive effects against a wide spectrum of seizures. In fact, highly purified CBD has been approved in the US and Europe as a medication with good efficacy and...
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
Invasion and metastasis of aggressive breast cancer cells to other organs is the final and fatal step during cancer progression. Recently, the Id-1 protein was found to be abnormally overexpressed and to...
Safety and Tolerability of Cannabidiol in Parkinson Disease: An Open Label, Dose-Escalation Study
Parkinson disease (PD) is a neurodegenerative disorder very common among the older population. Since standard treatments often only partially relieve symptoms, many patients turn to complementary and alternative medication such as cannabis....
Self-reported Illicit Drug Use Among Norwegian University and College Students: Association with Age, Gender, and Geography
In many Western countries, illicit drug use has been purportedly prevalent among students in higher education, even more so than in the general population. A recent study on the self-reported drug use...
Stress, Emotional Intelligence and the Intention to Use Cannabis in Spanish Adolescence: Influence of COVID-19 confinement
The disease brought about by the SARS-CoV-2, COVID-19 coronavirus has had an unprecedented global impact. Confinement to control the outbreak may have mental health consequences for many vulnerable populations, including adolescents. To...
Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerativ
Tetrahydrocannabinol (THC), a major constituent of the plant cannabis, can interact with endocannabinoid receptors abundant on neurons, thereby affecting multiple neuronal processes. In particular, a group of scientists recently investigated the ability...