Pharmacological blockers of the cannabinoid receptor type-1 (CB1) were shown in both research and clinical settings to deliver highly efficient anti-obesity results. However, the first generation of these drugs, such as Rimonabant,...
Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics
When the brain is attacked by infections, microglia, the immune cells that reside inside and regulate inflammation in the brain, are activated and initiate inflammatory processes to destroy the foreign pathogens and...
Adolescent CB1 receptor antagonism influences subsequent social interactions and neural activity in female rats
The endogenous cannabinoid system (ECS), which consists of endocannabinoids - signalling lipid molecules, cannabinoid receptors CB1 and CB2 that they bind to, and enzymes that metabolize and transport them, has recently emerged...
Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis
Benzodiazepines constitute a class of medication with sedative properties commonly used as the main treatment for a variety of neurological conditions, including most noticeably insomnia, anxiety, alcohol use disorders and seizure disorders....
Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies
Melanoma is a highly metastatic skin cancer with increasing incidence and mortality rate worldwide. In 2018 alone, approximately 280,000 new cases and 61,000 deaths associated with melanoma were reported in 46 countries....
Cannabinoids: A new hope for breast cancer therapy?
Breast cancer is one of the most common cancers, affecting approximately 1 in 10 women at some points in their lives. Although the rates of mortality have declined since the late 1990s,...
Associations Between Prenatal Cannabis Exposure and Childhood Outcomes
As cannabis becomes increasingly legalized and its use among pregnant women is documented more and more frequently in the US, an urgent need to understand whether cannabis use during pregnancy is associated...
Cannabinoids use in adolescents and young adults with cancer: a single-center survey
Cannabis use is common in young people for various reasons, ranging from relaxation to sense of belonging in social groups. However, the self-initiated use of cannabis and cannabis-derived compounds (such as THC...
Cannabis use, subsequent other illicit drug use and drug use disorders: A 16- year follow-up study among Swedish adults
Cannabis is the most commonly consumed illicit drug globally, with approximately 192 million users as of 2018. A critical and fiercely debated issue among physicians and public health experts is whether cannabis...
Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer
As a leading cause of death, cancer is a major public health problem with approxmiately 12.7 million new cases a year in the USA alone. A focus of oncology is palliative care,...