Clinical Takeaway In a controlled crossover trial of healthy males, CBD at both low and high single doses failed to directly reduce cortical excitability compared to placebo, suggesting its anti-seizure effects may...
Cannabinoid Clinical Trials: EEG Sleep Insomnia RCT
Clinical Takeaway In this small pilot trial of 20 adults with diagnosed insomnia disorder, a single oral dose of 10 mg THC combined with 200 mg CBD reduced total sleep time compared...
Cannabidiol for Fibromyalgia: Clinical Trial Evidence
Clinical Takeaway In this randomized, double-blind, placebo-controlled trial of fibromyalgia patients, CBD did not demonstrate superiority over placebo in reducing pain. These findings suggest that the widespread clinical use of CBD for...
`Cannabinoid Clinical Trials: Cannabis for Student Mental Health`
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-designed with university students, to address mental health and substance use concerns during the high-risk transition into higher education. Digital tools...
`Cannabinoid Clinical Trials: Cannabis for Chronic Back Pain`
Clinical Takeaway In this phase 3 trial of 820 adults with chronic low back pain, the full-spectrum cannabis extract VER-01 was evaluated over a 12-week double-blind period followed by longer-term open-label phases....
Endocannabinoid System Research: Cannabis in Mental Health RCTs
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-designed with university students, for improving mental health and substance use outcomes during a high-risk transitional period. Digital tools like this...
`Endocannabinoid System Trial: Cannabis for Chronic Back Pain`
Clinical Takeaway In this phase 3 randomized controlled trial, 820 adults with chronic low back pain received either VER-01, a full-spectrum cannabis extract, or placebo over a 12-week double-blind period, followed by...
Medical Cannabis Evidence-Based Care: CBD Autism RCT
Clinical Takeaway In a small randomized crossover trial, autistic children aged 5 to 12 received weight-based CBD oil dosing over 12-week periods, allowing researchers to directly compare CBD against placebo within the...
Cannabidiol for Lennox-Gastaut: Clinical Trial Evidence
Clinical Takeaway Plant-derived cannabidiol (CBD) oral solution produced meaningful reductions in drop seizures in patients with Lennox-Gastaut syndrome even at thresholds below the standard 50% benchmark used in clinical trials. Caregiver-reported outcomes...
Endocannabinoid System Research: Cannabis for Endometriosis
Clinical Takeaway Researchers attempted a randomized controlled trial comparing inhaled THC-dominant cannabis, oral cannabinoid oil, and placebo for endometriosis pain, but faced significant feasibility challenges in completing the study. While many patients...