This small multiple-baseline study suggests that a probiotics-plus-PEA regimen may support function and wellbeing in some individuals with OA; these preliminary, hypothesis-generating findings warrant evaluation in larger, controlled studies.
Tiny Pilot Study Hints at Possible Benefits of Probiotics Plus PEA for Osteoarthritis—But Far Too Early to Draw Conclusions
The graph demonstrated a clear pain reduction for one participant. Analyses also suggested improvements in patient-specified functional scales, wellbeing, and anxiety for all participants.
Precision prediction of posttraumatic stress disorder symptom surges: A pilot study integrating real-time daily data with supervised learning.
The application of machine learning algorithms to daily diary data represents a valuable tool for improving dynamic prediction of posttraumatic stress disord…
Advertising Among Cannabidiol (CBD) Retailers in North Carolina: A Pilot Study.
Cannabidiol (CBD) is widely available to consumers who report using it for health-related purposes. However, little is known about the marketing of CBD. This…
Cannabidiol-hyaluronic acid combination delivered rectally for attenuating abacterial prostatitis symptoms: Single-arm open-label pilot clinical trial.
Chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological disorder with a significant impact on quality-of-life. This…
Feasibility and acceptability of a physical activity intervention to reduce prenatal cannabis use: results of an open pilot trial.
Cannabis is commonly used among reproductive-aged individuals, and prenatal cannabis use (PCU) has increased dramatically in recent years, despite guidance w…
Probiotics and palmitoylethanolamide (PEA) for osteoarthritic pain: individual effects in a multiple baseline design study.
Osteoarthritis (OA) is a leading cause of chronic pain. As healthcare services struggle to meet demand to treat chronic pain, many individuals self-manage th…
The Effects of an Acute Dose of Cannabidiol on Health and Two-Mile Time Trial Performance-A Pilot Study.
CED Clinical Relevance #64Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. 🔬 Evidence Watch | CED Clinic CbdExerciseAthletic PerformancePilot StudyCardiovascular JournalNutrientsStudy TypePilot StudyPopulationHuman participants Why This MattersThis pilot study addresses a growing clinical...
Small Pilot Trial Finds Medicinal Cannabis Feasible to Study in Adolescents with Tourette Syndrome — But Efficacy Remains Unknown
The findings suggest that the study protocol is feasible and acceptable to patients with TS and their families. A fully powered study is needed to evaluate the efficacy of MC in adolescent TS.
Pilot Study Finds Salivary Metabolite Shifts in Autistic Children Treated with Medical Cannabis—But Evidence Remains Preliminary
“Sixty-five potential cannabis-responsive biomarkers exhibiting a shift toward the TD physiological levels were identified in children with ASD after MC treatment.” — Authors’ caution that larger trials are needed is appropriate, but the term ‘Cannabis-Responsive’ implies causation the design cannot support.