Although cannabinoid-based medications were generally safe and acceptable to adults aged over 50 years, these estimates are limited by the lack of a control condition and considerable heterogeneity. Nevertheless, they complement and are consistent with comparable evidence from randomised controlled trials.
Medical Cannabis in Older Adults: Promising Interest, Thin Evidence
Evidence of efficacy for relief of an array of symptoms is overall scanty, and almost all study participants are aged < 60 years. The risk of known and potential adverse effects is considerable, with concerns for cognitive, cardiovascular and gait and stability effects in older adults.
Older Adults on Medical Cannabis Face Doubled Intoxication Risk When Co-Prescribed Narrow Therapeutic Index Drugs
The risk of drug-related intoxication was 2.61 (95% CI 1.42–4.79) amongst 3,926 patients exposed to cannabis and DNTI compared to 12,223 controls.
Common But Manageable: What a 58-Trial Meta-Analysis Reveals About Cannabis Medicine Side Effects in Older Adults
Although CBMs in general are safe and acceptable in middle aged and older adults, one needs to be mindful of certain common dose-dependent side-effects of THC-containing CBMs.
Cannabinoids Show Modest Promise for Cancer-Related Appetite Loss in Older Adults, but Evidence Remains Thin
Cannabinoids offer promise in enhancing the quality of life for older individuals with active neoplastic disease. However, to establish comprehensive guidelines, further research with larger sample sizes is essential.
Older Adults Report Pain, Sleep, and Mood Benefits from Medical Cannabis — But the Evidence Has Major Gaps
Among older adults, medical cannabis is used more often by women, with CBD-containing cannabis oils being the most commonly used. Users reported improved pain, sleep, and mood symptoms at follow-up — though without a control group, these self-reported changes cannot be causally attributed to cannabis.
Cannabis Medicines Appear Broadly Tolerated in Adults Over 50, But Key Uncertainties Remain
Although cannabinoid-based medications were generally safe and acceptable to adults aged over 50 years, these estimates are limited by the lack of a control condition and considerable heterogeneity. Nevertheless, they complement and are consistent with comparable evidence from randomised controlled trials.
Older Adults with COPD More Likely to Receive Potentially Risky Cannabinoid Prescriptions, Study Finds
Although incident off-label oral cannabinoid use was relatively low among all older Ontarian adults, this drug class was used with greater frequency and more often in potentially concerning ways among older adults with COPD.
Older Adults and Medical Cannabis: Promising Interest, Scarce Evidence
Evidence of efficacy for relief of an array of symptoms is overall scanty, and almost all study participants are aged < 60 years. The risk of known and potential adverse effects is considerable, with concerns for cognitive, cardiovascular and gait and stability effects in older adults.
Older Adults on Prescribed Cannabis Report Well-Being Gains, But Study Cannot Rule Out Placebo or Natural Recovery
Older aged individuals experience considerable improvement in health and well-being when prescribed cannabis-based medicinal products — though these findings come from an observational registry without a comparator arm, meaning improvement cannot be attributed solely to the intervention.