We identified nine SNPs significantly associated with a change in risk of having a mental disorder. The lead SNP was rs12805732 (Gene: Diacylglycerol Lipase Alpha; DAGLA). Four SNPs had substantial heterogeneity (Iยฒ>60%). DAGLA had the strongest association with disease risk in gene-based analysis.
Bridging reward and resilience: the endocannabinoid system as a unifying mechanism in exercise-induced protection against major depressive disorder.
Major depressive disorder (MDD) refers to a complex mental disorder defined by hindered reward system and hindered stress resilience. The limitations of trad…
CB2R-mediated GPX4 stabilization: a new avenue for treating cognitive impairment in elderly migraine patients.
Migraine is frequently associated with cognitive impairment, a pathology linked to microglial dysfunction and neuroinflammation. Ferroptosis, a form of iron-…
Regular Cannabis Use is Associated with a Diminished Anandamide Response to a Standard Exercise Stimulus: A Pilot Study.
The endocannabinoid system (ECS) is increasingly recognized as an important regulator of many physiological systems. People who use products derived from Twe…
Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies.
Headache disorders, including migraine, tension-type headache, trigeminal autonomic cephalalgias, post-traumatic headache and medication overuse headache, re…
Cannabinoid Effects of Metamizol/Dipyrone: A Possible Second Life in Pediatric Anesthesia for a Vintage Drug.
CED Clinical Relevance #56Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic PainPediatricAnesthesiaEndocannabinoidAnalgesia JournalBiomedicinesStudy TypeClinical StudyPopulationHuman participants Why This MattersThis study explores metamizol's cannabinoid-like properties, which could explain...
Progressive endocannabinoid system dysregulation in autosomal dominant polycystic kidney disease.
CED Clinical Relevance #56Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic AdpkdEndocannabinoid SystemKidney DiseasePainInflammation JournalMolecular medicine (Cambridge, Mass.)Study TypeClinical StudyPopulationHuman participants Why This MattersThis study provides the...
Prenatal THC exposure and binge-like alcohol drinking in early adolescence: From sex-specific drinking vulnerability to abnormal endocannabinoid-dopamine nexus in the nucleus accumbens.
Endocannabinoid (eCB) signalling is pivotal for brain programming, including the reward system neurodevelopment. Prenatal exposure to ฮ We hypothesise that p…
Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.
Antidepressant drugs are the first-line treatment for chronic stress-related psychiatric disorders such as major depressive disorder, anxiety disorders, and …
Exploring the neuroprotective effects of phytocannabinoids on oxygen-glucose deprived neurons in an in vitro model of stroke.
Stroke is a leading cause of death and disability worldwide, but therapeutic options to reduce or prevent neuronal damage are extremely limited. Cannabinoids…