Cannabis Dosing Guidelines for Family Medicine: Evidence-Based Research on Endocannabinoids
Prenatal cannabis dosing guidelines are essential for family medicine clinicians to understand safe use during pregnancy. Evidence-based research on endocannabinoids informs these guidelines. Clinicians should integrate these guidelines to optimize…
Enhancing the endocannabinoid system to treat residual disease in relapse-free multiple sclerosis.
A new consensus from Italian neurologists proposes enhancing the endocannabinoid system multiple sclerosis treatment approach for patients with relapse-free disease. The algorithm combines cannabinoid agents with lifestyle interventions to address…
LINC01996 suppresses non-small cell lung cancer proliferation and metastasis by orchestrating the miR-12115/CNRIP1/Ras signaling axis.
Preclinical research identifies CNRIP1 cannabinoid receptor protein as a tumor suppressor in lung cancer models. This laboratory study reveals new mechanisms of endocannabinoid system proteins in cancer biology, though clinical applications remain…
The role of cannabinoid ligands in neurodegenerative diseases: emerging anti-inflammatory, immunomodulation and disease-modifying perspectives.
Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies. Althoug...
Aryl-Cyclohexanone as a Potential CB2 Agonist: In Vitro and In Silico Evidence in Inflammatory Modulation.
Inflammation is an evolutionarily conserved adaptive process essential for host defense against harmful stimuli, aimed at restoring homeostasis. However, exa...
Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice.
The endocannabinoid system (ECS) and the autophagy receptor p62 are both implicated in metabolic regulation and obesity, yet the mechanisms linking these pat...
Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion.
Fatty acid-binding protein 7 (FABP7) assists in the intracellular trafficking of endogenous cannabinoids and polyunsaturated fatty acids (PUFAs) and has been...
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice.
Researchers found that increasing FABP5 protein expression in mouse brain amygdala reduces stress-induced cocaine-seeking behavior. This endocannabinoid system cocaine addiction treatment research provides insights into potential therapeutic targets,…
Radical Revelations: The Interplay of Nitrosative Stress, the Endocannabinoid System, and Treatment of Age-Related Disorders.
New endocannabinoid system neurodegeneration research reveals complex interactions between cannabis compounds and brain inflammatory pathways. This review examines how ECS modulation may influence nitrosative stress in neurodegenerative diseases.…
Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache.
Pre-clinical research identifies endocannabinoid system dysfunction as a potential mechanism underlying post-traumatic headache. The study reveals increased enzymes that break down protective endocannabinoids in pain circuits following mild traumatic…