The role of cannabinoid ligands in neurodegenerative diseases: emerging anti-inflammatory, immunomodulation and disease-modifying perspectives.
Neurodegenerative diseases (NDs) constitute a growing global health burden driven by population aging and remain without disease-modifying therapies. Althoug...
Aryl-Cyclohexanone as a Potential CB2 Agonist: In Vitro and In Silico Evidence in Inflammatory Modulation.
Inflammation is an evolutionarily conserved adaptive process essential for host defense against harmful stimuli, aimed at restoring homeostasis. However, exa...
Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice.
The endocannabinoid system (ECS) and the autophagy receptor p62 are both implicated in metabolic regulation and obesity, yet the mechanisms linking these pat...
Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion.
Fatty acid-binding protein 7 (FABP7) assists in the intracellular trafficking of endogenous cannabinoids and polyunsaturated fatty acids (PUFAs) and has been...
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice.
Researchers found that increasing FABP5 protein expression in mouse brain amygdala reduces stress-induced cocaine-seeking behavior. This endocannabinoid system cocaine addiction treatment research provides insights into potential therapeutic targets,…
Radical Revelations: The Interplay of Nitrosative Stress, the Endocannabinoid System, and Treatment of Age-Related Disorders.
New endocannabinoid system neurodegeneration research reveals complex interactions between cannabis compounds and brain inflammatory pathways. This review examines how ECS modulation may influence nitrosative stress in neurodegenerative diseases.…
Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache.
Pre-clinical research identifies endocannabinoid system dysfunction as a potential mechanism underlying post-traumatic headache. The study reveals increased enzymes that break down protective endocannabinoids in pain circuits following mild traumatic…
Differential Effects of Oleoyl Serine and HU-910 on Anxiety and Depression in WKY Rats
The endocannabinoid system depression anxiety connection is actively researched for therapeutic potential. This study investigates Oleoyl Serine and HU-910 effects on anxiety and depression behaviors in WKY rats. Results show sex-specific anxiolytic and…
Endocannabinoid Responses to Relief of Obstruction in Acute Injured Kidney: A Prospective Study
The study investigates renal obstruction endocannabinoids and their role in acute kidney injury. It characterizes changes in circulating endocannabinoid levels before and after relief of obstruction. Understanding these responses may guide future…
Insights Into Cannabis and Cannabinoids: Chemical Properties, Legal Perspectives, and Therapeutic Applications.
Cannabinoids chemical properties play a crucial role in the therapeutic applications of cannabis. This review explores the chemical compounds and legal perspectives surrounding cannabinoids. Understanding these properties helps inform clinical practice…