The use of cannabis during pregnancy is increasing, in line with its growing societal acceptance and legalization. Cannabis use mainly concerns its active co…
Therapeutic use of cannabinoids in age-related pain: Current evidence and clinical perspectives.
Pain is a frequently reported long lasting symptom among older adults, often associated with age-related conditions such as osteoarthritis, neuropathies, and…
Probiotics and palmitoylethanolamide (PEA) for osteoarthritic pain: individual effects in a multiple baseline design study.
Osteoarthritis (OA) is a leading cause of chronic pain. As healthcare services struggle to meet demand to treat chronic pain, many individuals self-manage th…
Targeting molecular pathways in neuropathic cancer pain: from mechanisms to novel therapeutics.
Neuropathic cancer pain (NCP) remains a formidable clinical adversary, severely compromising the quality of life for cancer survivors. Its pathogenesis is hi…
Therapeutic relevance of an EU-GMP certified
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and frequently co-occurs with chronic pain. Worldwide…
Investigational drugs in PTSD.
Post-traumatic stress disorder (PTSD) remains one of psychiatry’s most challenging disorders, common, disabling, and biologically complex. Despite decades of…
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice.
Anandamide (AEA), an endogenous cannabinoid, is thought to exert an inhibitory role in the basolateral amygdala complex (BLA), dampening hypothalamus-pituita…
endocannabinoid system clinical research: CBD & psychosis
Clinical Takeaway In a study of individuals at clinical high risk for psychosis, a single dose of CBD influenced the relationship between hippocampal glutamate levels and prefrontal brain activity during verbal memory...
`Endocannabinoid System & Adolescent Cannabis Use Risk`
Clinical Takeaway Adolescents with higher levels of depression and anxiety symptoms show increased likelihood of initiating and using cannabis more frequently over time, supporting the self-medication hypothesis in this age group. This...
Endocannabinoid System Research: Cannabis Use After Trauma
Clinical Takeaway Insomnia symptoms present before a traumatic event may increase the risk of alcohol and cannabis use in the weeks and months following trauma exposure. Clinicians treating trauma survivors in emergency...