CDKL5 Deficiency Disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early disruptions of synaptic maturation and network stability…
What Taking a Daily Omega-3 Supplement Can Do for Women’s Health
✦ New CED Clinical Relevance #70Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. ⚒ Cannabis News | CED Clinic Women'S HealthAnti-InflammatoryEndocannabinoid SystemSupplementsHormones Why This MattersWhile this focuses on omega-3 supplementation, it's clinically relevant...
Loss of dystrophin reduces CB1 receptor expression and endocannabinoid-dependent synaptic plasticity in the cerebellar cortex.
Duchenne Muscular Dystrophy (DMD) is a debilitating degenerative condition with complex musculoskeletal and cognitive symptoms. The protein responsible, dyst…
Can Cannabis Replace Opioids for Chronic Pain? A New Review Maps What We Know—and What Remains Uncertain
Clinical evidence has shown that cannabinoids can significantly reduce the intensity of chronic pain, particularly in cases of neuropathy, multiple sclerosis, arthritis, and other painful conditions that are unresponsive to conventional treatments. However, the full integration of medical cannabis into clinical practice faces significant obstacles, including the need for standardized dosing, long-term safety data, and regulatory frameworks.
Cannabis and Male Fertility: What the Science Actually Shows
Endocannabinoids exert both positive and negative effects on the male reproductive system. They facilitate erectile function by modulating neurotransmission and vasodilation, offering potential therapeutic avenues for conditions like erectile dysfunction and prostatitis. However, chronic exogenous cannabinoid use, mainly of tetrahydrocannabinol, poses risks to male reproductive health by disrupting spermatogenesis, causing hormonal imbalances, and potentially influencing cancer cell proliferation.
Cannabis and Male Fertility: What the Science Actually Shows
ECBs exert both positive and negative effects on the male reproductive system. They facilitate erectile function by modulating neurotransmission and vasodilation, offering potential therapeutic avenues for conditions like erectile dysfunction and prostatitis. However, chronic exogenous cannabinoid use, mainly of tetrahydrocannabinol, poses risks to male reproductive health by disrupting spermatogenesis, causing hormonal imbalances, and potentially influencing cancer cell proliferation.
Endocannabinoid System Research: Cannabinoids in Pediatrics
Clinical Takeaway Cannabinoids have been studied across a wide range of pediatric medical conditions, with evidence drawn from both interventional trials and real-world observational data. The current body of research captures both...
Can Cannabinoids Slow Ageing? Early Lab Evidence Is Intriguing, But Human Proof Remains Absent
“The non-psychoactive cannabinoid cannabidiol (CBD) shows particular promise, with mechanistic studies demonstrating it may work through autophagy induction and activation of antioxidative systems.”
Cannabis and the Heart and Vessels: What the Science Actually Says
Although existing literature suggests a direct role of cannabinoids in the pathogenesis of atherosclerosis, the correlation between cannabinoids and other vascular diseases was only reported in some case series or observational studies, and its role and precise mechanisms remain unclear.
GPR3 in neuro-metabolic-immune-reproductive nexus – a potential therapeutic target for Multi-System diseases.
GPR3(G-protein-coupled receptor 3), an orphan G-protein-coupled receptor (GPCR) with constitutive Gs activity, is expressed in the brain, liver, ovary, and o…