Why a Teenage Brain Is Not a Small Adult Brain: Cannabis, CB1 Receptors, and Cortical Development
Discussions of cannabis and the adolescent brain usually stop at the assertion that it harms development, without saying what the mechanism is or how firm the evidence behind it is. The endocannabinoid system helps organize cortical maturation, and a…
How the Body Switches Off Its Own Cannabinoids, and What Happened When a Drug Company Tried to Stop It
Endocannabinoid degradation runs through two enzymes: FAAH, which converts anandamide to arachidonic acid and ethanolamine, and MAGL, which converts 2-AG to arachidonic acid and glycerol and handles about 85 percent of brain 2-AG hydrolysis. Blocking…
Where Cannabinoid Receptors Actually Live: A Working Map of CB1 and CB2 Across the Human Body
CB1 and CB2 receptor distribution is the anatomical foundation under every clinical question in cannabis medicine, and most summaries of it are vaguer than the primary data require. This page maps both receptors from the original cloning and…
Most of What Gets Said About Cannabis and the Gut Microbiome Comes From Mice
Cannabis gut microbiome claims circulate widely, but a systematic review across every clinical condition found only nine human studies, two of which were clinical trials, with effects that varied in direction. The mechanism linking cannabinoid signaling…
The Skin Has Its Own Cannabinoid Receptors. That Is Not the Same as Topicals Working.
The skin endocannabinoid system is documented anatomy, with CB1 and CB2 receptors mapped to keratinocytes, sebocytes, hair follicles, sweat glands, sensory nerves, mast cells, and macrophages in human tissue. That receptor map is the most common…
How Diet and Gut Microbiota Influence the Endocannabinoid System
A July 2026 mechanistic review explains the dietary impact on endocannabinoid system by detailing how fatty acids and gut microbiota jointly regulate the endocannabinoidome. This review clarifies the biological mechanisms without clinical treatment…
Medicinal Cannabis and Fibromyalgia: Endocannabinoid Biomarkers Trial
This fibromyalgia endocannabinoid biomarkers trial evaluated whether oral THC:CBD cannabis oil changes blood markers in women with fibromyalgia. The study found no significant changes in plasma PEA, OEA, or SEA levels compared to placebo. These results…
Blog: Can AI-Guided Cannabinoid Care Become Reliable?
AI-guided cannabinoid care may eventually help explain why patients respond so differently to similar products, doses, and diagnoses. This essay examines how longitudinal data, product chemistry, physiology, and clinical outcomes could support better…
Can the Endocannabinoid System Help Explain Bruxism? What a New Neurobiological Model Proposes
A July 2026 Frontiers in Neuroscience paper proposes the endocannabinoid system bruxism neuromodulation hypothesis, suggesting ECS may regulate brain circuits behind bruxism. This is a translational model, not a clinical trial, highlighting a promising…
Medicinal Cannabis and Fibromyalgia: Biomarker Trial Insights
The fibromyalgia endocannabinoid biomarkers trial found no significant changes in peripheral blood markers after oral THC:CBD cannabis oil treatment, despite reported pain relief. This highlights the complexity of monitoring cannabis effects in…