Tetrahydrocannabinol (THC), a major constituent of the plant cannabis, can interact with endocannabinoid receptors abundant on neurons, thereby affecting multiple neuronal processes. In particular, a group of scientists recently investigated the ability...
Adolescent CB1 receptor antagonism influences subsequent social interactions and neural activity in female rats
The endogenous cannabinoid system (ECS), which consists of endocannabinoids - signalling lipid molecules, cannabinoid receptors CB1 and CB2 that they bind to, and enzymes that metabolize and transport them, has recently emerged...
Dry eye and its link to cannabis and the endocannabinoid signaling system
THC Regulates Tearing via Cannabinoid CB1 Receptors In Summary: Over the past decade, changes in the legal status of cannabis in many US states have been accompanied by increasing cannabis use; however,...
The expression of cannabinoid receptors in sperm cells is correlated with sperm maturation and quality
Evaluation of cannabinoid receptors Type 1 and Type 2 mRNA expression in mature versus immature spermatozoa from fertile and infertile males In Summary: The endocannabinoid system (ECS) is a signalling system of...
Abnormalities in the endocannabinoid system are associated with common female reproductive disorders
The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders In Summary The endocannabinoid system (ECS) consists of cannabinoids produced naturally by...
The endocannabinoid system mediates the enhanced analgesia and GI safety advantage of a newly developed NSAID derivative
Enhanced Analgesic Effects and GI Safety of A Novel Hydrogen Sulfide‐Releasing Anti‐Inflammatory Drug (ATB‐352): A Role for Endogenous Cannabinoids In Summary Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the preferable alternatives to opioids in...
The use of cannabis for pain management: Potential side effects on myofascial tissues of the musculoskeletal system.
Sensitivity of the Fasciae to the Endocannabinoid System: Production of Hyaluronan-Rich Vesicles and Potential Peripheral Effects of Cannabinoids in Fascial Tissue In Summary Myofascial tissue is a thin, strong, fibrous connective tissue...
The endocannabinoid receptor CB2 is a regulator of trauma-inducing anxiety and a potential target for PTSD drugs
Cannabinoid CB2 receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear In Summary Researchers recently identified a signaling pathway in the endocannabinoid system that regulates...
Neurological and neurodegenerative conditions, physical activities, and the endocannabinoid system – how might all these be linked?
Can physical activity support the endocannabinoid system in the preventive and therapeutic approach to neurological disorders? In Summary The endocannabinoid signaling system (ECS) of the body includes naturally produced chemicals called cannabinoids,...
Urgent need for clinical trials investigating the effects of cannabinoids on hormone receptor-positive breast cancer therapy
Cannabinoids and Hormone Receptor-Positive Breast Cancer Treatment In Summary Breast cancer (BC) is the most common cancer in women worldwide. Approximately 70-80% of BC cases fall into the category of hormone...