CBG, CBN, CBC, and THCV: Which Cannabinoid Claims Come From Human Studies, and Which Do Not
Minor cannabinoids reach store shelves with confident functional claims years before anyone gives them to a human being in a controlled trial. CBG now has two small human studies that reached different conclusions, CBN has two randomized sleep trials…
Cannabis Terpenes When You Inhale Them: One Controlled Human Trial, a Large Preclinical Literature, and a Dose Gap Nobody Mentions
Inhaled cannabis terpenes have exactly one controlled human trial behind them, and it found that 15 mg of vaporized d-limonene selectively reduced THC-induced anxiety and paranoia while producing no effect at all when given on its own. Every other…
What Cannabis Does to Heart Rate and Blood Pressure, and Which Patients Should Take That Seriously
The cannabis heart rate and blood pressure response is fast and dose-dependent, with a faster pulse, higher pressure while lying down, and a drop on standing. Pooled pharmacoepidemiological data associate cannabis use with acute coronary syndrome,…
Which Cannabis Terpene Claims Hold Up, and Which Ones Do Not
Do cannabis terpenes do anything, or are the charts on dispensary menus decoration? One controlled human trial supports d-limonene reducing THC-induced anxiety when the two are inhaled together, while limonene alone was indistinguishable from placebo.…
One Randomized Trial and a Pile of Survey Data: Where Cannabis for Headache Actually Stands
Cannabis for headaches now has one randomized placebo-controlled trial behind it, in acute migraine, where vaporized flower containing both THC and CBD outperformed placebo while CBD alone did not. Nothing in the controlled literature supports cannabis…
Where Pediatric Cannabinoid Evidence Is Strong, Where It Is Thin, and Where It Does Not Exist At All
Medical cannabis for children has randomized, placebo-controlled evidence in exactly three drug-resistant epilepsy syndromes, using a pharmaceutical cannabidiol preparation under specialist supervision. The largest autism trial reported a null primary…
A Parent’s Guide to Cannabis and Teen Anxiety: What the Research Supports, What It Warns About, and What Actually Treats Adolescent Anxiety
No randomized trial has tested cannabis and teen anxiety together, and the one cannabinoid study in young people was an open-label trial of 31 participants with no control group. Meanwhile a 488-child randomized trial found cognitive behavioral therapy…
Cannabinoid Therapeutics in HIV: Strong Pain Trials, an Appetite Literature From Another Era, and Interaction Data That Has Not Been Updated
The case for cannabis for HIV rests almost entirely on two randomized placebo-controlled trials in HIV-associated sensory neuropathy, where roughly half of treated patients reached a clinically meaningful pain response against a fifth to a quarter on…
Cannabis and Antibiotic Resistance: What Cannabigerol Actually Does to MRSA, and What It Does Not Do in People
The evidence on cannabis and antibiotic resistance is real, reproducible, and entirely preclinical: cannabigerol and cannabidiol inhibit MRSA at low concentrations, clear biofilms, and work in rodent models. Not one human trial has tested a cannabinoid…
Most of What Gets Said About Cannabis and the Gut Microbiome Comes From Mice
Cannabis gut microbiome claims circulate widely, but a systematic review across every clinical condition found only nine human studies, two of which were clinical trials, with effects that varied in direction. The mechanism linking cannabinoid signaling…