Cannabinoids & Insulin Sensitivity
CED Clinical Relevance #62 Moderate Clinical Relevance Useful mechanistic human data, but not evidence that cannabis improves metabolism in everyday life. Clinical Insight | CED Clinic This cannabinoid insulin sensitivity study shows that cannabinoid…
What the 2026 DOJ Rescheduling Order Means in Practice
On April 23, 2026, the U.S. DOJ moved state-licensed medical cannabis to Schedule III, the first federal acknowledgment of accepted medical value in 55 years. Dr. Caplan breaks down what actually changed for patients, physicians, and the research…
Self-reported reasons for medical and nonmedical cannabis use in Australia: A cross-sectional analysis of the International Cannabis Policy Study 2023.
A 2023 Australian survey found that cannabis users frequently report dual medical-recreational motives rather than distinct categories. This cross-sectional analysis of 3,042 adults reveals that australian medical cannabis use patterns are more nuanced…
Cannabis modalities matter for momentary subjective drug effects.
A new ecological momentary assessment study reveals that cannabis consumption method subjective effects vary significantly between delivery mechanisms. Researchers found vaporizers produced less subjective intoxication while bongs were associated with…
Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People With Multiple Sclerosis.
A real-time smartphone-based study of 258 MS patients revealed that higher pain levels drive increased cannabis use and decreased alcohol consumption. This research using ecological momentary assessment provides clinical evidence that MS patients make…
Prenylated apigenin derivatives from Cannabis sativa L.: isolation, biosynthesis, and anti-inflammatory properties.
Laboratory research has identified prenylated apigenin derivatives from Cannabis sativa with anti-inflammatory properties, representing novel non-psychotropic compounds beyond traditional cannabinoids. While these prenylated apigenin cannabis…
Cannabis and Mental Health: A Review.
A comprehensive JAMA review reveals the stark gap between widespread cannabis use for mental health conditions and actual clinical evidence. While patients commonly self-medicate with cannabis for psychiatric symptoms, this systematic analysis found…
Medicinal plants in the management of muscle loss and sarcopenia: A narrative review of preclinical and clinical evidence from eight species.
A 2024 narrative review identifies cannabis muscle health applications alongside seven other medicinal plants for sarcopenia management. While this academic inclusion validates cannabis research interest, clinical applications await controlled trial…
Pilot study on cannabis-induced alterations in platelet function: implications for transfusion medicine.
A pilot study reveals cannabis extracts can alter platelet function in laboratory settings, raising questions about cannabis effects on platelet function and transfusion safety. While preliminary, this research highlights the need for further…
Quasi-randomization to Cannabinoid Condition in Studies of US Legal Market Cannabis: Characteristics of Accepters Versus Decliners of Condition Assignment.
A methodology study examining cannabis research selection bias found systematic differences between participants who accept versus decline assigned cannabis conditions. This quasi-randomization research provides crucial insights for interpreting legal…