Prenylated apigenin derivatives from Cannabis sativa L.: isolation, biosynthesis, and anti-inflammatory properties.
Laboratory research has identified prenylated apigenin derivatives from Cannabis sativa with anti-inflammatory properties, representing novel non-psychotropic compounds beyond traditional cannabinoids. While these prenylated apigenin cannabis…
Cannabis and Mental Health: A Review.
A comprehensive JAMA review reveals the stark gap between widespread cannabis use for mental health conditions and actual clinical evidence. While patients commonly self-medicate with cannabis for psychiatric symptoms, this systematic analysis found…
Medicinal plants in the management of muscle loss and sarcopenia: A narrative review of preclinical and clinical evidence from eight species.
A 2024 narrative review identifies cannabis muscle health applications alongside seven other medicinal plants for sarcopenia management. While this academic inclusion validates cannabis research interest, clinical applications await controlled trial…
Pilot study on cannabis-induced alterations in platelet function: implications for transfusion medicine.
A pilot study reveals cannabis extracts can alter platelet function in laboratory settings, raising questions about cannabis effects on platelet function and transfusion safety. While preliminary, this research highlights the need for further…
Quasi-randomization to Cannabinoid Condition in Studies of US Legal Market Cannabis: Characteristics of Accepters Versus Decliners of Condition Assignment.
A methodology study examining cannabis research selection bias found systematic differences between participants who accept versus decline assigned cannabis conditions. This quasi-randomization research provides crucial insights for interpreting legal…
Regular cannabinoid use and inflammatory biomarkers: Systematic review and hierarchical meta-analysis.
A comprehensive systematic review of cannabis inflammatory biomarkers found associations with anti-inflammatory markers in observational studies. However, the clinical significance of these laboratory changes remains uncertain, and the predominance of…
Discrepancies between subjective and objective cognition in persons with multiple sclerosis: Exploring the role of cannabis use.
Research examining cannabis cognitive effects in multiple sclerosis patients found that cannabis users report greater perceived cognitive deficits than non-users. This cross-sectional study of 847 MS patients provides important insights into the…
NfL and GFAP quantification and associations with mental health in recreational cannabis users-Results from the Swiss study on recreational cannabis access via pharmacies.
A Swiss study measuring cannabis brain damage biomarkers study results in 331 regular users found no evidence of nerve damage and unexpectedly lower levels of brain injury markers. These objective biomarker findings challenge assumptions about cannabis…
Randomised Controlled Trial Evidence on Medicinal Cannabis for Treatment of Mental Health and Substance Use Disorders: A Scoping Review.
A comprehensive scoping review of randomized controlled trials reveals limited high-quality medicinal cannabis mental health evidence for treating psychiatric and substance use disorders. The systematic review highlights significant gaps in rigorous…
Health-related quality of life in patients receiving medicinal cannabis: systematic review and meta-analysis of primary research findings 2015-2025.
A comprehensive systematic review and meta-analysis examining medicinal cannabis quality of life outcomes found consistent improvements across chronic conditions. The research analyzed validated HRQL measures from 2015-2025, showing benefits in short,…