| Journal | Annals of medicine and surgery (2012) |
| Study Type | Randomized Trial |
| Population | Human participants |
This is the first systematic review specifically examining CBD safety in healthy populations, filling a critical evidence gap. Most safety data comes from patient populations where underlying conditions may confound adverse event profiles.
This meta-analysis of four RCTs involving 269 healthy adults found CBD significantly increased diarrhea risk compared to placebo (RR = 5.85). The study focused on common adverse events including headache, fatigue, abdominal pain, and respiratory symptoms. While the sample size was modest and limited to healthy volunteers, this represents the most rigorous safety assessment of CBD in non-patient populations to date.
“This confirms what I observe clinically—diarrhea is CBD’s most predictable dose-limiting side effect, even in healthy individuals. The magnitude of risk increase aligns with my clinical experience across diverse patient populations.”
💬 Join the Conversation
Have a question about how this applies to your situation? Ask Dr. Caplan →
Want to discuss this topic with other patients and caregivers? Join the forum discussion →
Have thoughts on this? Share it:
FAQ
This study item was assembled from normalized source metadata and pipeline scoring.