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CBD and Threat Anticipation in Alcohol Use Disorder: What a Small Randomized Trial Found
CBD alcohol use disorder randomized trial: In a randomized crossover experiment, 800 mg daily CBD did not measurably change threat-anticipation brain activity, cognitive performance, anxiety, or craving in a small non-treatment-seeking alcohol use…
Can a Text-Message Intervention Reduce Cannabis-Impaired Driving? A New Randomized Trial
Cannabis-impaired driving text intervention trial: personalized feedback reduced self-reported driving after cannabis use in 149 emerging adults. The randomized study followed participants for three and six months. It did not measure objective…
Does Low-Dose CBD Cause Psychoactive Effects? Findings from a Dose-Dependent Trial
A recent randomized trial investigated dose-dependent side effects cannabinoids by testing oral CBD doses from 20 to 200 mg. The study found only the 200 mg dose produced a small but significant pleasant drug effect, while lower doses did not differ from…
Evidence-based Therapist Guided Introduction to Online Heavy Cannabis Use Treatment in Canadian Adults: A Randomized Controlled Trial (RCT)
Many people who engage in heavy cannabis use do not seek treatment, and those who do face barriers like wait times and costs. Therapist guided cannabis treatment delivered online can reduce these barriers. This study evaluates a Canadian online program…
Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Using Psychoactive Substances
Monoamine oxidase inhibitors drug interactions are critical to understand for patients using psychoactive substances. This review highlights safety considerations and treatment data. MAOIs remain important for treatment-resistant psychiatric conditions…
Cannabis Use Among Individuals Treated with Medication for Opioid Use Disorder: Correlates, Patterns, and Motivations for Use
Cannabis use among individuals on MOUD is common and linked to various clinical factors. This study examines patterns and motivations for cannabis use in this population. Understanding these factors can inform clinical practice and patient care.
Phase 1 Open-Label Pilot Trial of H4 dTMS for Moderate-to-Severe Cannabis Use Disorder
Deep repetitive transcranial magnetic stimulation (dTMS) is being studied as a treatment for cannabis use disorder (CUD). This phase 1 open-label pilot trial evaluated H4 dTMS combined with standard care for adults with moderate-to-severe CUD. The study…
Cannabidiol in Anorexia Nervosa: A Double-Blind Randomized Placebo Controlled Pilot Study
This cannabidiol anorexia nervosa study evaluates safety, pharmacokinetics, and symptom change in patients with anorexia nervosa. The randomized controlled trial used a double-blind design to assess cannabidiol effects. Results suggest cannabidiol is…
Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke: Rationale and Study Protocol
Head down tilt ischemic stroke therapy aims to increase collateral blood flow, a key factor in successful recanalization. This approach is being studied in acute ischemic stroke patients undergoing mechanical thrombectomy. The trial evaluates safety,…
Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis.
This systematic review evaluates the efficacy and safety of cannabinoids for neuropsychiatric symptoms in dementia. Neuropsychiatric symptoms are common in dementia and pose significant challenges. Cannabinoids offer a promising treatment option for…