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Cannabinoid Clinical Trials: Cannabis in At-Risk Teens

Clinical Takeaway

Research suggests that standard anti-cannabis messages often fail because they don’t account for the wide range of attitudes adolescents already hold about cannabis. This study tested a sequential messaging approach that first challenged negative reactions to prevention messages before delivering a more targeted follow-up communication, specifically in middle and high school students who had not yet used cannabis. The findings point toward more personalized, rebuttal-based strategies as a potentially more effective framework for adolescent cannabis prevention compared to one-size-fits-all campaigns.

#28 A Rebuttal-Based Social Norms-Tailored Cannabis Intervention for At-Risk Adolescents.

Citation: Donaldson Candice D et al.. A Rebuttal-Based Social Norms-Tailored Cannabis Intervention for At-Risk Adolescents.. Prevention science : the official journal of the Society for Prevention Research. 2021. PMID: 33791930.

Study type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural  |  Topic area: Pediatrics  |  CED Score: 10

Design: 5 Journal: 0 N: 3 Recency: 0 Pop: 3 Human: 1 Risk: -2

Quality Gate Alerts:
  • Preclinical only

Abstract: Many past cannabis prevention campaigns have proven largely ineffective due in part to the diversity of adolescents’ cannabis-relevant beliefs. The current studies evaluated the impact of a sequential multiple message approach tailored to the usage norms of adolescents expressing negative attitudes toward a cannabis prevention appeal. A multiple-message strategy was implemented-initial unfavorable message evaluations were invalidated using attitudinal rebuttal feedback prior to presenting a third tailored communication. Participants were cannabis-abstinent middle and high school students (ages 11 to 16). Study 1 (N = 808) compared effects of gain- and loss-framed messages tailored to each student’s normative usage perceptions. In Study 2 (N = 391), students were randomly assigned to receive a tailored or non-tailored message after receiving feedback meant to destabilize anti-message attitudes. For at-risk adolescents in Study 1 who perceived cannabis use as normative, a tailored gain-framed message resulted in the lowest usage intentions (p < .05). In Study 2, a conditional multiple-moderated mediation model showed that for high-risk teens with normative beliefs and pro-cannabis attitudes, exposure to a tailored gain-framed communication was associated with decreased cannabis attitude certainty, and lower usage intentions 2 months later (p < .05). Findings have implications for sequential messaging utilization in mass media campaigns and support the efficacy of tailored messages over a one-size-fits-all media approach. Further, results suggest that systematically weakening resistance to persuasive communications and tailoring messages consistent with individually perceived peer norms is an effective prevention strategy.

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