Clinical Takeaway Topical cannabis balms were tested in women with breast cancer experiencing joint pain and stiffness caused by aromatase inhibitor therapy. The trial evaluated whether this approach was practical and well-tolerated,...
Cannabinoid Clinical Trials: Cannabis Effects on Alcohol Urge
Clinical Takeaway Cannabis can increase or decrease the urge to drink alcohol depending on a person’s working memory capacity, meaning the mental ability to hold and manage information. People with lower working...
Endocannabinoid System Research: Cannabis Use in Pregnancy
Clinical Takeaway Children born to mothers who used cannabis during pregnancy showed a modestly elevated risk of autism spectrum disorder and a smaller increased risk of ADHD based on pooled data from...
Cannabinoids for Autism: Clinical Evidence & ASD Research
Clinical Takeaway Several randomized clinical trials have examined cannabis derivatives, including CBD-rich preparations, for core and associated symptoms of autism spectrum disorder, with findings suggesting potential benefits for behavioral challenges, anxiety, and...
Endocannabinoid System & Teen Anxiety: Clinical Evidence
Clinical Takeaway Adolescents with depression and anxiety symptoms show increased likelihood of initiating and escalating cannabis use over time, suggesting internalising disorders may drive substance use as a coping mechanism. Clinicians working...
Adolescent Cannabis Use and Psychotic Disorder Risk
Clinical Takeaway Adolescent cannabis use is associated with increased risk of developing psychotic, bipolar, depressive, and anxiety disorders in adolescence and young adulthood, based on large population-level longitudinal data tracking clinically diagnosed...
Endocannabinoid System & Trauma Sleep Research Insights
Clinical Takeaway Insomnia symptoms present before a traumatic event may increase the risk of developing problematic alcohol or cannabis use in the weeks and months following trauma exposure. This relationship appears to...
Cannabinoid Clinical Trials: CBD Cortical Excitability Study
Clinical Takeaway In this rigorous crossover trial, neither a low nor a high single dose of CBD directly altered cortical excitability or produced measurable sedation in healthy adults. This suggests that CBD’s...
Cannabinoid Clinical Trials: EEG Sleep & Insomnia RCT
Clinical Takeaway In this pilot randomized controlled trial of 20 adults with diagnosed insomnia, a single oral dose of 10 mg THC combined with 200 mg CBD actually reduced total sleep time...
endocannabinoid system clinical research eating disorders
Clinical Takeaway The REAL 2.0 study followed Canadian youth for 15 years to examine how adolescent risk factors like body image concerns and disordered eating contribute to mental health and substance use...