Migraine is frequently associated with cognitive impairment, a pathology linked to microglial dysfunction and neuroinflammation. Ferroptosis, a form of iron-…
Regular Cannabis Use is Associated with a Diminished Anandamide Response to a Standard Exercise Stimulus: A Pilot Study.
The endocannabinoid system (ECS) is increasingly recognized as an important regulator of many physiological systems. People who use products derived from Twe…
Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies.
Headache disorders, including migraine, tension-type headache, trigeminal autonomic cephalalgias, post-traumatic headache and medication overuse headache, re…
`Cannabinoids and PTSD: Clinical Evidence for Co-Occurring SUD`
Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments, and cannabis use does not appear to undermine treatment outcomes compared to...
Endocannabinoid System Research: Cannabis in Family Medicine
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-developed with university students, to address mental health and substance use challenges during the college transition period. Digital tools like Minder...
Cannabinoid Clinical Trials: Athlete Mental Health Evidence
Clinical Takeaway Retired professional athletes from high contact team sports show meaningful rates of depression, anxiety, and other mental health challenges after their playing careers end. Factors like repeated head trauma, identity...
Cannabidiol & Glucose Tolerance: Clinical Trial Evidence
Clinical Takeaway In this pilot study, short-term low-dose CBD supplementation did not improve glucose tolerance or meaningfully alter the gut microbiome in sedentary adults with overweight or obesity. While animal studies and...
Perceived Safety of Cannabis Use During Pregnancy and Changes in Perception over Time (2017-2021): A National Survey of US Adults.
CED Clinical Relevance #56Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic PregnancySafetyPublic HealthPatient EducationSurvey Research JournalJournal of general internal medicineStudy TypeClinical StudyPopulationHuman participants Why This MattersPerceived safety...
Sanitation of medical cannabis flowers (Cannabis sativa L., flos): comparing current technologies and non-thermal plasma novelties from safety and quality perspectives.
CED Clinical Relevance #56Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic SafetyQuality ControlImmunocompromisedCannabis ProcessingContamination JournalJournal of cannabis researchStudy TypeClinical StudyPopulationHuman participants Why This MattersCannabis flower contamination with...
`Cannabinoid Clinical Trials for Mental & Substance Disorders`
Clinical Takeaway Systematic review and meta-analysis of randomized controlled trials found limited evidence supporting cannabinoids as a primary treatment for mental disorders or substance use disorders. Current data do not establish clear...