✦ New CED Clinical Relevance #78 Strong Clinical Relevance High-quality evidence with meaningful patient or clinical significance. ResearchDosingSafetyCBDTHC Why This Matters Clinicians prescribing cannabinoid medications need formulations that deliver consistent, predictable dosing...
You Guys are Getting Paid
When your colleagues mention their pharmaceutical rep lunches while you’re out here explaining the endocannabinoid system to skeptical patients for free. Further Reading Cannabis NewsRecreational drugs triple the risk of stroke in...
`Cannabidiol & Cortical Excitability: Clinical Trial Evidence`
Clinical Takeaway In a controlled crossover trial of healthy males, CBD at both low and high single doses failed to directly reduce cortical excitability compared to placebo, suggesting its anti-seizure effects may...
Cannabinoid Clinical Trials: EEG Sleep Insomnia RCT
Clinical Takeaway In this small pilot trial of 20 adults with diagnosed insomnia disorder, a single oral dose of 10 mg THC combined with 200 mg CBD reduced total sleep time compared...
`Endocannabinoid System Research: Cannabis for Anxiety`
Clinical Takeaway Cannabis use for anxiety produced measurable daily reductions in anxiety symptoms, but the effects differed meaningfully depending on whether people used flower or edible products. CBD-containing products showed anxiolytic benefits,...
Cannabidiol for Fibromyalgia: Clinical Trial Evidence
Clinical Takeaway In this randomized, double-blind, placebo-controlled trial of fibromyalgia patients, CBD did not demonstrate superiority over placebo in reducing pain. These findings suggest that the widespread clinical use of CBD for...
endocannabinoid system clinical research: Eating & Youth
Clinical Takeaway Over a 15-year period, this Canadian cohort study tracked adolescents into early adulthood to understand how early risk factors like body image concerns and disordered eating contribute to mental health...
`Cannabinoid Clinical Trials: PTSD and Substance Use Disorders`
Clinical Takeaway Trauma-focused therapy remains effective for PTSD even in patients who are actively using cannabis, including those with co-occurring substance use disorders. Patients should not be required to stop cannabis use...
`Cannabinoid Clinical Trials: Cannabis for Student Mental Health`
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-designed with university students, to address mental health and substance use concerns during the high-risk transition into higher education. Digital tools...
Endocannabinoid System Research in Athlete Mental Health
Clinical Takeaway Retired professional athletes from high contact team sports face elevated rates of depression, anxiety, and cognitive symptoms after their careers end, with factors like concussion history, identity loss, and poor...