Epilepsy is a very common disorder characterized by recurrent, spontaneous seizures, and a seizure is induced by the abnormal, synchronous...
Use of Dronabinol Improves Appetite and Reverses Weight Loss in HIV/AIDS-Infected Patients
HIV wasting syndrome is defined as the involuntary loss of more than 10% of baseline body weight and is associated...
No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
Cannabidiol (CBD) is a component of the plant cannabis with various therapeutic benefits including antidepressant and anxiolytic (anxiety-relieving). Despite being...
Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep
Until now, medical cannabis remains a highly controversial substance, being condoned in different forms by half of the states but...
The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents
The endogenous cannabinoid system is a signaling system of the human body that comprises endocannabinoids (such as anandamide and 2-AG),...
Anti-invasion Effects of Cannabinoids Agonist and Antagonist on Human Breast Cancer Stem Cells
In most types of solid tumors, the metastasis of invasive tumor cells from their origin to different organs throughout the...
The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers
Tobacco smoking is a leading cause of preventable death, yet only one-third of those who try can successfully quit smoking....
Using measured cannabidiol and tetrahydrocannabinol metabolites in urine to differentiate marijuana use from consumption of commercial cannabidiol products
The current method for detection of marijuana use measures 11-nor-carboxy-Δ9-tetrahydrocannabinol (11-COOH-THC), the major metabolite of THC in a person’s urine....
The proposed mechanisms of action of CBD in epilepsy
Cannabidiol (CBD) has demonstrated positive effects against a wide spectrum of seizures. In fact, highly purified CBD has been approved...
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
Invasion and metastasis of aggressive breast cancer cells to other organs is the final and fatal step during cancer progression....