WHY IT MATTERS: Patients with chronic jaw and facial pain who have not found relief through standard treatments now have emerging clinical trial evidence supporting sublingual cannabis extracts as a potential therapeutic option worth discussing with their provider. CLINICAL OVERVIEW: Sublingual cannabis extract administration has demonstrated meaningful reductions in myofascial pain among patients with temporomandibular disorders, a condition historically resistant to conventional pharmacological approaches. The findings add to a growing body of evidence supporting cannabinoid-based interventions for chronic orofacial pain, where inflammation and central sensitization play significant roles.
0 days without (Lenny, Simpsons)
When your patient swears they haven’t used cannabis in months, but the urinalysis disagrees with their timeline. Further Reading Cannabis NewsRecreational drugs triple the risk of stroke in young people, study finds...
Success Kid
Got prescribed cannabis for chronic pain. Actually read the dosing guidelines and didn’t immediately text everyone about it. Further Reading Cannabis NewsRecreational drugs triple the risk of stroke in young people, study...
Batman Slapping Robin
“Maybe we should try CBD for inflammation.” Batman: “That’s literally what the clinical evidence supports.” Robin gets slapped anyway because evidence-based medicine is apparently still controversial. Further Reading Cannabis NewsRecreational drugs triple...
endocannabinoid system clinical research: Eating Disorders
Clinical Takeaway The REAL 2.0 cohort study tracked Canadian youth over 15 years to examine how adolescent risk factors like body image concerns and disordered eating contribute to mental health, eating disorders,...
`Endocannabinoid System Research: Cannabis for PTSD & SUD`
Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments, and cannabis use does not appear to undermine treatment outcomes compared to...
Endocannabinoid System Research: Cannabis in Mental Health Care
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-designed with university students, for addressing mental health and substance use challenges during the college transition period. Digital tools like this...
Cannabinoid Research: Mental Health in Retired Athletes
Clinical Takeaway Retired professional athletes from high contact team sports face elevated rates of depression, anxiety, and cognitive concerns compared to the general population, with symptoms often linked to repetitive head impacts...
Endocannabinoid System Research: Cannabinoids for Children
Clinical Takeaway Cannabinoids have been studied across a range of pediatric medical conditions, with the current evidence base drawing from hundreds of studies including clinical trials and observational reports. The strongest and...
endocannabinoid system clinical research: Phase 3 Cannabis Trial
Clinical Takeaway In this phase 3 randomized controlled trial of 820 adults with chronic low back pain, VER-01, a full-spectrum cannabis extract, was evaluated over a 12-week blinded treatment period with extended...