In many Western countries, illicit drug use has been purportedly prevalent among students in higher education, even more so than in the general population. A recent study on the self-reported drug use...
Stress, Emotional Intelligence and the Intention to Use Cannabis in Spanish Adolescence: Influence of COVID-19 confinement
The disease brought about by the SARS-CoV-2, COVID-19 coronavirus has had an unprecedented global impact. Confinement to control the outbreak may have mental health consequences for many vulnerable populations, including adolescents. To...
Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerativ
Tetrahydrocannabinol (THC), a major constituent of the plant cannabis, can interact with endocannabinoid receptors abundant on neurons, thereby affecting multiple neuronal processes. In particular, a group of scientists recently investigated the ability...
Association Between Marijuana Use and Cardiovascular Disease in US Adults
The prevalence of marijuana use has risen steadily for the past decade, reaching approximately 200 million consumers worldwide. At the same time, marijuana has been shown in both laboratory and clinical research...
Anti-obesity therapy with peripheral CB1 blockers: from promise to safe practice
Pharmacological blockers of the cannabinoid receptor type-1 (CB1) were shown in both research and clinical settings to deliver highly efficient anti-obesity results. However, the first generation of these drugs, such as Rimonabant,...
Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics
When the brain is attacked by infections, microglia, the immune cells that reside inside and regulate inflammation in the brain, are activated and initiate inflammatory processes to destroy the foreign pathogens and...
Adolescent CB1 receptor antagonism influences subsequent social interactions and neural activity in female rats
The endogenous cannabinoid system (ECS), which consists of endocannabinoids - signalling lipid molecules, cannabinoid receptors CB1 and CB2 that they bind to, and enzymes that metabolize and transport them, has recently emerged...
Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis
Benzodiazepines constitute a class of medication with sedative properties commonly used as the main treatment for a variety of neurological conditions, including most noticeably insomnia, anxiety, alcohol use disorders and seizure disorders....
Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies
Melanoma is a highly metastatic skin cancer with increasing incidence and mortality rate worldwide. In 2018 alone, approximately 280,000 new cases and 61,000 deaths associated with melanoma were reported in 46 countries....
Cannabinoids: A new hope for breast cancer therapy?
Breast cancer is one of the most common cancers, affecting approximately 1 in 10 women at some points in their lives. Although the rates of mortality have declined since the late 1990s,...