HIV wasting syndrome is defined as the involuntary loss of more than 10% of baseline body weight and is associated with chronic diarrhea, weakness, or fever. This common complication of HIV has...
No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
Cannabidiol (CBD) is a component of the plant cannabis with various therapeutic benefits including antidepressant and anxiolytic (anxiety-relieving). Despite being a known regulator of brain functions (hence its benefits against the above...
Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep
Until now, medical cannabis remains a highly controversial substance, being condoned in different forms by half of the states but prohibited at a federal level in the states. A plethora of scientific,...
The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents
The endogenous cannabinoid system is a signaling system of the human body that comprises endocannabinoids (such as anandamide and 2-AG), cell-surface receptors (CB1 and CB2), as well as proteins responsible for the...
Anti-invasion Effects of Cannabinoids Agonist and Antagonist on Human Breast Cancer Stem Cells
In most types of solid tumors, the metastasis of invasive tumor cells from their origin to different organs throughout the body is often lethal to patients. Recent research has uncovered the crucial...
The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers
Tobacco smoking is a leading cause of preventable death, yet only one-third of those who try can successfully quit smoking. This highlights the current lack of effective treatment options for nicotine dependence....
Using measured cannabidiol and tetrahydrocannabinol metabolites in urine to differentiate marijuana use from consumption of commercial cannabidiol products
The current method for detection of marijuana use measures 11-nor-carboxy-ฮ9-tetrahydrocannabinol (11-COOH-THC), the major metabolite of THC in a personโs urine. However, commercially available CBD products sold without purity regulations often contain trace...
The proposed mechanisms of action of CBD in epilepsy
Cannabidiol (CBD) has demonstrated positive effects against a wide spectrum of seizures. In fact, highly purified CBD has been approved in the US and Europe as a medication with good efficacy and...
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
Invasion and metastasis of aggressive breast cancer cells to other organs is the final and fatal step during cancer progression. Recently, the Id-1 protein was found to be abnormally overexpressed and to...
Safety and Tolerability of Cannabidiol in Parkinson Disease: An Open Label, Dose-Escalation Study
Parkinson disease (PD) is a neurodegenerative disorder very common among the older population. Since standard treatments often only partially relieve symptoms, many patients turn to complementary and alternative medication such as cannabis....