#85 Research Authority
Peer-reviewed research curated for clinical relevance and evidence quality.
Recent research digest. 10 of 10 most recent studies from our monitored feeds.
Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review.
Castro Samuel Gonçalves et al.
Journal of cannabis research • 2026
Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals.
Chia Chee W et al.
American journal of physiology. Endocrinology and metabolism • 2026
# Clinical Summary This study found that nabilone and CB1 receptor antagonists had acute effects on how the body handles glucose and insulin in healthy men, though the specific metabolic changes require examination of the full results. The research suggests that manipulating the endocannabinoid system through different cannabinoid receptor modulators can alter insulin secretion and glucose disposal in the short term.
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru®, vs an Oil-Based Formulation, Epidyolex®, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study.
Bendik Igor et al.
CNS drugs • 2026
# Clinical Summary This study compared how the body absorbs and processes CBD from a powder formulation (CBtru) versus an oil-based formulation (Epidyolex) in healthy adults, testing both fasted and fed conditions. The research aimed to determine whether the powder formulation could provide better bioavailability and safety compared to the standard oil-based CBD product already approved for pediatric epilepsy.
The effects of cannabidiol on sleep disturbances within a sample of high trait worriers: A double-blind, randomized placebo controlled trial.
Gournay L Riley et al.
Experimental and clinical psychopharmacology • 2026
# Clinical Summary In a study of 63 adults with high trait worry, a 300 mg daily dose of cannabidiol significantly reduced sleep disturbances and improved sleep quality compared to a 50 mg dose over two weeks. These findings suggest that higher-dose cannabidiol may be effective for managing sleep problems in anxious individuals, though further research is needed to confirm these results and establish optimal dosing.
Effect of Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) on Neuropsychiatric Outcomes: A Systematic Review and Meta-Analysis.
Choudhury Ishraq et al.
Clinical therapeutics • 2026
# Clinical Summary This systematic review and meta-analysis examined whether GLP-1 receptor agonist medications, commonly used to treat type 2 diabetes and aid weight loss, may also improve brain-related conditions such as cognitive decline, mood disorders, and substance use problems. The study found inconsistent evidence across individual research trials regarding whether these medications provide protective effects for the brain and mental health beyond their primary benefits for blood sugar control and weight reduction.
Acute and long-term psychiatric consequences of synthetic cannabinoids and related novel psychoactive substances: A systematic review.
Ricci Valerio et al.
Psychiatry research • 2026
# Clinical Summary This systematic review found that synthetic cannabinoids and related novel psychoactive substances are associated with serious acute psychiatric complications including psychosis, anxiety, and agitation, as well as long-term mental health consequences such as persistent psychotic disorders and cognitive impairment. The severity and duration of psychiatric effects appear to exceed those associated with traditional cannabis use, with certain user populations showing elevated vulnerability to adverse outcomes.
Adolescent Cannabis Use After Cannabis Legalization and the COVID-19 Pandemic.
Young-Wolff Kelly C et al.
JAMA network open • 2026
# Clinical Summary This study examined how recreational cannabis legalization in California and the COVID-19 pandemic affected adolescent cannabis use rates. The research aimed to understand whether major policy changes and large-scale societal disruptions influenced teen cannabis use patterns, which is important because early cannabis use is linked to worse health outcomes and educational performance.
Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People With Multiple Sclerosis.
Kim Jeeyeon et al.
Archives of physical medicine and rehabilitation • 2026
# Clinical Summary This study tracked 258 people with multiple sclerosis using smartphone surveys four times daily for two weeks to examine whether their daily use of substances like alcohol, caffeine, nicotine, cannabis, and opioids was associated with fatigue, pain, stress, and depression symptoms. The research identified specific patterns of how these substances relate to symptom severity on a day-to-day basis, which could help inform better management strategies for MS patients.
Baseline characteristics and feasibility of clinical outcome measures in CDKL5 deficiency disorder: The CANDID observational study.
Liogier d’Ardhuy Xavier et al.
Epilepsia • 2026
# Clinical Summary CDKL5 deficiency disorder is a rare genetic seizure disorder affecting brain development in children, for which new therapies like gene replacement are being developed and tested. This study evaluated which clinical tests and measurement tools work best for assessing how these new treatments affect patients’ brain function and development.
Mitochondrial Calcium Signaling in the Brain: From Molecular Mechanisms to Behavioral Outcomes.
Pouvreau Sandrine et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry • 2026
# Clinical Summary Mitochondria in the brain regulate calcium signaling in neurons and glial cells, which controls how brain cells communicate through synapses and maintain proper electrical activity. Dysfunction in how mitochondria handle calcium can affect synaptic strength, neuronal excitability, and overall brain network function, with potential implications for neurological conditions.
Digest generated April 22, 2026 at 11:49 AM