The Endocannabinoid System and Cannabinoids: A Physician’s Guide to Human Biology
Understand how the endocannabinoid system (ECS) regulates human homeostasis. Dr. Benjamin Caplan, MD explains CB1 and CB2 receptors, anandamide, 2-AG, and cannabinoid medicine.
Cannabinoids and Dementia: New Meta-Analysis Finds No Clear Benefit
cannabinoids dementia meta-analysis: A new systematic review and meta-analysis of nine randomized trials involving 334 participants found no clear improvement in agitation, broader neuropsychiatric symptoms, or cognition with cannabinoid-based…
Cannabinoids for Mental Health and Addiction: What 200
Cannabinoids for mental health were examined across 200 randomized and observational studies. Anxiety and PTSD signals were limited by low certainty, indirectness, and heterogeneity, while depression showed no evident benefit. THC increased withdrawals…
Cannabinoids and Cognitive Function in Bipolar Disorder: What a New Study Found
A new study on cannabinoids cognition bipolar disorder examined whether cannabis use correlates with improved timing and attention in people with bipolar disorder. Chronic cannabis users performed similarly to healthy adults, and an acute THC challenge…
Some Cannabinoids May Ease Common Chronic Pain Conditions, Study Finds
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A Synthetic Cannabinoid Did NOT Reduce Opioid Use After Knee Replacement Surgery
A new postoperative randomized trial found no significant opioid reduction from a synthetic cannabinoid after total knee arthroplasty. The findings challenge broad assumptions that cannabinoids reliably reduce opioid use in every pain setting. The study…
Evidence-Based Cannabis for Dementia-Related Behavioral Agitation
A meta-analysis of 10 RCTs shows medical cannabis can reduce dementia-related agitation—a behavioral symptom that devastates both patients and caregivers. Cannabinoids showed effectiveness comparable to antipsychotics but with a safer profile, especially…
Cannabinoids for Autism
This Evidence Watch reviews a 2026 systematic review on cannabinoids for autism in children and adolescents. The paper found limited RCT evidence, with one whole-plant high-CBD, low-THC extract showing improvement in global clinical impression and social…
Cannabinoids and Opioid Use in GI Cancer Chemotherapy: Large EHR Study
This study analyzes cannabinoid prescribing in oncology among gastrointestinal cancer patients starting chemotherapy. Only 2.4% received FDA-approved cannabinoids, with higher opioid co-prescribing observed. The findings highlight prescribing patterns…
Cannabis & Dental Care
Clinical Relevance #62 Emerging but Limited Evidence Mechanistic promise exists, but clinical translation remains early and uncertain. Clinical Insight Cannabis in dentistry is biologically plausible but clinically immature. The key risk is…
