Some Cannabinoids May Ease Common Chronic Pain Conditions, Study Finds
✦ New CED Clinical Relevance #76 Strong Clinical Relevance High-quality evidence with meaningful patient or clinical significance. PainResearchCBDTHCCannabinoidsSafetyHemp Why This Matters Clinicians need current evidence on cannabinoid efficacy…
A Synthetic Cannabinoid Did NOT Reduce Opioid Use After Knee Replacement Surgery
A new postoperative randomized trial found no significant opioid reduction from a synthetic cannabinoid after total knee arthroplasty. The findings challenge broad assumptions that cannabinoids reliably reduce opioid use in every pain setting. The study…
Evidence-Based Cannabis for Dementia-Related Behavioral Agitation
A meta-analysis of 10 RCTs shows medical cannabis can reduce dementia-related agitation—a behavioral symptom that devastates both patients and caregivers. Cannabinoids showed effectiveness comparable to antipsychotics but with a safer profile, especially…
Cannabinoids for Autism
This Evidence Watch reviews a 2026 systematic review on cannabinoids for autism in children and adolescents. The paper found limited RCT evidence, with one whole-plant high-CBD, low-THC extract showing improvement in global clinical impression and social…
Cannabis Prescriptions Did Not Lower Opioid Use in GI Cancer Patients Starting Chemotherapy
A large study of gastrointestinal cancer patients examined cannabinoid prescribing oncology opioid use GI cancer patterns after chemotherapy initiation. Only 2.4% received FDA-approved cannabinoid prescriptions, and those patients were more likely to use…
Cannabinoids and Opioid Use in GI Cancer Chemotherapy: Large EHR Study
This study analyzes cannabinoid prescribing in oncology among gastrointestinal cancer patients starting chemotherapy. Only 2.4% received FDA-approved cannabinoids, with higher opioid co-prescribing observed. The findings highlight prescribing patterns…
Cannabis & Dental Care
Clinical Relevance #62 Emerging but Limited Evidence Mechanistic promise exists, but clinical translation remains early and uncertain. Clinical Insight Cannabis in dentistry is biologically plausible but clinically immature. The key risk is…
What a 2026 Lancet Psychiatry Review Actually Shows, and What It Doesn’t
This cannabinoids mental health meta-analysis reviews 54 randomized trials across psychiatric and substance use conditions. It identifies modest benefits in insomnia, Tourette syndrome, ASD traits, and cannabis withdrawal, but with low certainty. For…
Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke: Rationale and Study Protocol
Head down tilt ischemic stroke therapy aims to increase collateral blood flow, a key factor in successful recanalization. This approach is being studied in acute ischemic stroke patients undergoing mechanical thrombectomy. The trial evaluates safety,…
Clinical Trials on Cannabis and Mental Health Care
Clinical trial cannabis mental health research shows limited evidence for cannabinoids treating mental disorders. Safety concerns remain significant and require further study. Established treatments remain the primary approach until stronger evidence…