| Journal | Anesthesia progress |
| Study Type | Clinical Study |
| Population | Human participants |
With cannabis use increasing rapidly and products becoming more potent, anesthesia providers need evidence-based guidance for perioperative management. This review addresses critical safety considerations for the growing population of cannabis-using surgical patients.
This comprehensive review examines cannabis pharmacology and perioperative implications for anesthesia providers. The authors detail how chronic cannabis use downregulates CB1 receptors, leading to tolerance and withdrawal, while affecting multiple organ systems including cardiovascular, respiratory, and gastrointestinal function. Key clinical concerns include delayed gastric emptying increasing aspiration risk, cardiovascular instability, and potential drug interactions. The review emphasizes the need for thorough preoperative screening and individualized anesthetic management based on usage patterns and product potency.
“This review fills a crucial knowledge gap for anesthesiologists who increasingly encounter cannabis users but lack standardized protocols. The emphasis on CB1 receptor downregulation and multi-system effects provides the mechanistic framework needed for rational perioperative decision-making.”
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This study item was assembled from normalized source metadata and pipeline scoring.