This narrative review examines whether the endocannabinoid system may play a biochemical role in ADHD pathophysiology. It gathers 11 preclinical and 2 clinical studies and argues that ECS signaling may intersect with attention, impulsivity, and hyperactivity pathways. The core limitation is that the evidence remains thin, heavily preclinical, and far from proving that cannabinoid-based treatments are ready for clinical use in ADHD.
Enhanced Distal Signaling in Human Hippocampal Neurons despite Lower Intrinsic Excitability.
The hippocampus is critical for memory and spatial navigation, and is central to the pathophysiology of temporal lobe epilepsy – the most common drug-resista…
Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies.
Headache disorders, including migraine, tension-type headache, trigeminal autonomic cephalalgias, post-traumatic headache and medication overuse headache, re…