WHY IT MATTERS: Patients dealing with cancer-related cachexia, HIV-associated wasting, or medication-induced appetite suppression may have a clearer scientific basis for discussing cannabis-based appetite support with their physician. CLINICAL OVERVIEW: Cannabis has long been observed to stimulate appetite through its interaction with the endocannabinoid system, particularly via CB1 receptor activation in regions of the brain that regulate hunger and reward. This mechanism, commonly called “the munchies,” involves not just peripheral hunger signals but also a shift in how the brain perceives and prioritizes food-related cues.