WHY IT MATTERS: If you are a parent or caregiver of a teenager, this research reinforces why cannabis medicine should only be considered for adolescents under direct physician supervision with clear medical necessity, and why recreational teen use carries real psychiatric risk. CLINICAL OVERVIEW: Adolescent cannabis use has consistently been associated with increased risk of psychiatric disorders in the clinical literature, and new large-scale data continues to reinforce this concern. The developing brain is particularly vulnerable to exogenous cannabinoids, and early exposure during critical neurodevelopmental windows may alter endocannabinoid signaling in ways that predispose teens to conditions like psychosis, anxiety disorders, and depression.