WHY IT MATTERS: Pregnant individuals using cannabis for nausea, anxiety, or pain should know that emerging placental research suggests potential long-term psychiatric risks to their child that current safety guidelines may still be underestimating. CLINICAL OVERVIEW: Emerging research suggests that prenatal cannabis exposure may leave measurable biological signatures in placental tissue that are associated with increased schizophrenia risk in offspring. The placenta acts as a dynamic interface between maternal and fetal environments, and cannabinoids can cross this barrier and influence fetal neurodevelopment during critical windows of brain formation.