Compared with tobacco-only smokers, dual cannabis-tobacco smokers were younger (median age 53 vs 56 years; P=.006), had higher rates of rare and aggressive lung cancers (17% vs 4%; P=.007), more emphysema (64% vs 38%; P=.003), and lower gas diffusion capacity (63% vs 70%; P=.004).
Nearly 4 in 10 Young Lung Cancer Patients Also Smoked Cannabis—and Their Cancers Were More Aggressive
All patients who smoke cannabis also smoked tobacco, with no difference in self-reported pack-years and hair cotinine concentrations compared with tobacco-only smokers—yet dual smokers were younger at diagnosis and had higher rates of rare and aggressive lung cancers and emphysema.