WHY IT MATTERS: Patients managing chronic inflammatory conditions now have growing scientific rationale to discuss cannabinoid-based options with their physicians, but translating that science into safe, effective protocols still requires careful medical guidance rather than self-directed supplementation. CLINICAL OVERVIEW: The endocannabinoid system is a legitimate and increasingly well-characterized biological network that helps regulate immune tone and inflammatory signaling through receptors distributed throughout immune tissues, the gut, and the central nervous system. Phytocannabinoids such as CBD and THC interact with this system in ways that can modulate cytokine production, microglial activation, and oxidative stress pathways relevant to chronic inflammatory conditions.