Clinical Takeaway Children exposed to cannabis during the peripregnancy period showed associations with behavioral and developmental differences in offspring, with effects varying based on whether children had ASD symptoms. These findings suggest...
Endocannabinoid System & GLP-1 Receptor Mental Health Evidence
Clinical Takeaway GLP-1 receptor agonists, the drug class that includes medications like semaglutide, were studied for their potential causal effects on ten common mental health conditions using genetic analysis data. The findings...
Endocannabinoid System & Maternal Cytokines: Clinical Research
Clinical Takeaway Cannabis use during pregnancy is associated with measurable suppression of key immune signaling proteins (cytokines) in the mother’s bloodstream, findings confirmed through urine-verified exposure. Because the immune system plays a...
Endocannabinoid System Research: Cannabis for Endometriosis
Clinical Takeaway Medicinal cannabis is widely self-reported by people with endometriosis for pain relief, but rigorous clinical trial data confirming its efficacy remain absent. This Australian feasibility trial tested inhaled THC-dominant cannabis...
Cannabinoid Clinical Trials: CBD Gel Safety in Fragile X
Clinical Takeaway Transdermal cannabidiol gel (ZYN002) has demonstrated an acceptable long-term safety and tolerability profile in children and adolescents with Fragile X syndrome across an ongoing open-label extension study. The treatment targets...
endocannabinoid system clinical research: CBD & Psychosis
Clinical Takeaway In a small study of people at clinical high risk for psychosis, a single dose of CBD was found to influence the relationship between glutamate levels in the hippocampus and...
Endocannabinoid System Research: Cannabis for Autism
Clinical Takeaway Across randomized clinical trials, cannabis derivatives and their analogs showed promising early signals for improving core and associated symptoms of autism spectrum disorder, including social communication and behavioral challenges. The...
Endocannabinoid System & Teen Mental Health: Clinical Evidence
Clinical Takeaway Adolescents with higher levels of depression and anxiety symptoms were more likely to initiate and use cannabis more frequently over the following 18 months, supporting the idea that young people...
Endocannabinoid System Research: Trauma, Sleep & Cannabis Use
Clinical Takeaway Insomnia symptoms present before a traumatic event may increase the risk of alcohol and cannabis use in the weeks and months that follow, potentially through their influence on early posttraumatic...
`Endocannabinoid System & Adolescent Health: 15-Year REAL 2.0 Study`
Clinical Takeaway A 15-year Canadian cohort study tracked adolescents into early adulthood to examine how body image concerns and disordered eating in youth predict later eating disorders, mental health conditions, and substance...