Clinical Takeaway Trauma-focused therapies remain effective for PTSD even when patients are actively using cannabis, including those with co-occurring substance use disorders. Clinicians should not withhold or delay evidence-based PTSD treatment due...
`Endocannabinoid System Research: Athlete Mental Health`
Clinical Takeaway Retired professional athletes from high contact team sports face elevated rates of depression, anxiety, and cognitive concerns after their careers end, with factors like concussion history, abrupt retirement, and loss...
Endocannabinoid System Research: Cannabis for Chronic Pain
Clinical Takeaway Randomized controlled trial evidence through mid-2025 shows that cannabinoids provide modest pain relief for some chronic pain conditions, with effects varying based on THC-to-CBD ratio, product source, and route of...
Endocannabinoid System Research: Cannabinoids for Children
Clinical Takeaway Cannabinoids have been studied across a range of pediatric medical conditions, with the current evidence base drawing from over 270 studies including both interventional and observational designs. The available data...
Endocannabinoid System: Cannabis for Chronic Pain Review
Clinical Takeaway Clinical trials show that cannabis-based products, particularly those containing THC, provide modest reductions in chronic pain compared to placebo, though the overall quality of evidence remains low to moderate. Benefits...
Endocannabinoid System Research: Cannabis Use & Child ASD
Clinical Takeaway Children exposed to cannabis during the peripregnancy period showed associations with behavioral and developmental differences in early childhood, and these associations varied depending on whether ASD symptoms were present. The...
Endocannabinoid System & GLP-1 Mental Health Evidence
Clinical Takeaway GLP-1 receptor agonists, the drug class that includes medications like semaglutide, were studied using genetic analysis to assess their causal effect on ten psychiatric conditions. The findings suggest these medications...
Endocannabinoid System: Cannabis, Pregnancy & Cytokines
Clinical Takeaway Cannabis use during pregnancy is associated with measurable suppression of maternal immune signaling proteins called cytokines, which play a critical role in protecting both mother and developing fetus. This immune...
Endocannabinoid System Research: Cannabis Use in Pregnancy
Clinical Takeaway Children born to mothers who used cannabis during pregnancy showed a modestly elevated risk of autism spectrum disorder and a smaller increase in risk of ADHD, based on a pooled...
Endocannabinoid System & Trauma Sleep Research Findings
Clinical Takeaway Insomnia before a traumatic event increases the risk of developing posttraumatic stress symptoms, which in turn drives higher rates of alcohol and cannabis use in the weeks and months following...