If you use CBD products, understanding the entourage effect helps explain why full-spectrum formulations may offer greater therapeutic benefit than isolated CBD alone. An overview of the entourage effect explains how CBD works synergistically with other cannabinoids, terpenes, and flavonoids found naturally in full-spectrum hemp products to produce enhanced therapeutic outcomes compared to isolated CBD alone. The concept is supported by preclinical and emerging clinical data showing that combinations of non-psychotropic cannabinoids such as CBG, CBN, and CBDV amplify anti-inflammatory, anxiolytic, and analgesic effects.
Study: Minor Cannabinoids CBDV and CBG Show Powerful Anti-Inflammatory Effects When Combined
If you or someone you love uses high-potency cannabis products regularly, this research suggests the mental health risks are real—especially for younger users whose brains are still developing. A study published in the Journal of Ethnopharmacology found that 10 non-psychotropic phytocannabinoids—particularly CBDV and CBG—demonstrated meaningful anti-inflammatory effects. Researchers from the University of Chemistry and Technology and the Czech Academy of Sciences found that CBDV significantly reduced IL-6 and TNF-α production and inhibited NF-κB activation.
United Center Becomes First Major US Arena to Partner with Cannabis Drink Brands
New research shows that combining lesser-known cannabinoids like CBDV and CBG produces stronger anti-inflammatory effects than any single compound alone, supporting the value of full-spectrum hemp products. Chicago’s United Center, the largest entertainment arena in the US, has entered a historic partnership with cannabis drink brands, establishing the first-ever official THC sponsorship at a major American venue. The deal with RYTHM Inc.